DNAH14
Teški lanac 14 aksonsmnog dineina jest protein koji je kod ljudi kodiran genom DNAH14 sa hromosoma 1.[5]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 3.507 aminokiselina, a molekulska težina 399.895 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MGRRSQWIWA | MRCQMLVPVL | SLHIGLARAL | GCGCIASKIE | CLIRCNAPFP | ||||
| LLDAVGSVAS | QELQSLTGTV | GVTSGAAAYP | RWNLARARAP | PHLPGTQDPL | ||||
| RRVRDPTPIV | ASSPGRRRGS | WSGGYGQEAS | EPGVVGLCCA | VLPIHPSLAL | ||||
| AGVGGPDLRR | FQEGPQRPSD | HGAAEKHMET | FIPIDLTTEN | QEMDKEETKT | ||||
| KPRLLRYEEK | KYEDVKPLET | QPAEIAEKET | LEYKTVRTFS | ESLKSEKTEE | ||||
| PKDDDVIRNI | IRLREKLGWQ | TILPQHSLKY | GSSKIAIQKI | TLKKPLEDDG | ||||
| EFVYCLPRKS | PKSLYNPYDL | QVVSAHTAKH | CKEFWVITAS | FISKLDSSRT | ||||
| YSLDEFCEEQ | LQQATQALKQ | LEDIRNKAIS | EMKSTFLKVA | EKNEIKEYFE | ||||
| SKLSEDDTTH | FKLPKYRRLL | ETFFKFVMLV | DYIFQELIRQ | LMNTAVTLLL | ||||
| ELFNGSAGMP | FSVEKKNENL | IRTFKDNSFP | TGKTTNDCEE | LVDNSKLHAI | ||||
| SVQKSEVKTD | TDINEILNSV | EVGKDLRKTY | APIFEVNLCL | RIPAESDSSE | ||||
| NSKENFHESD | QCPEECVMFE | DEMSENKDNC | VKKHSSEELL | PKAKKSKEIS | ||||
| YNLEDIISAT | ITPLCQDPQL | SIFIDLVSIM | DLPNKTGSII | HYKEQTRWPD | ||||
| CHILFETDPA | YQNIIVNLLT | IIGNSMGLVN | AYSHKFIKYC | TMTEKAKIMS | ||||
| MKISSMGELT | SKEFEAILNR | FRNYFRHIVN | MAIEKRIGIF | NVVVESSLQQ | ||||
| LECDPTEIEE | FLEHFIFLNA | ISSKISKLEK | EFLTMSQLYS | VAKHHQIHIS | ||||
| EEQIAIFQVL | LLKFSQLKSS | MKLSKINKDT | AITKFRDNLE | ACISGLHVDV | ||||
| GNLKAKIRTP | LLLCAGTQVS | TAMEMIQTLS | GEAASLTNKA | KAYSHYQDCF | ||||
| SDSQSHMHSV | NVEEITQIVL | SEISDIEGDL | TLRKKLWEAQ | EEWKRASWEW | ||||
| RNSSLQSIDV | ESVQRNVSKL | MHIISVLEKE | IYSIFIIPSI | DDISAQLEES | ||||
| QVILATIKGS | PHIGPIKSQI | MFYNDCVKSF | VSSYSREKLE | KVHAGLMCHL | ||||
| EEVADLVVLD | TSNSRTKAIL | GALLILYVHC | RDIVINLLLK | NIFNAEDFEW | ||||
| TRHLQYKWNE | KQKLCYVSQG | NASFTYGYEY | LGCTSRLVIT | PLTDRCWLTL | ||||
| MEALHLNLGG | CPAGPAGTGK | TETVKDLAKC | ALFAFKCNTA | LIKLPNSLIV | ||||
| LTCFGLEKTV | LVMNTVMSFR | FVLEGKEIRI | NMSCAVFITM | NPRYGGGVEL | ||||
| PDNLKSLFRP | VAMMVPHYQM | IAEIILFSFG | FKSANSLSGK | LTNLYELARK | ||||
| QLSQQDHYNF | GLRSLKIVLI | MAGTKKREFK | CDTSDSLSEA | DETLIVIEAI | ||||
| REASLPKCPP | EDVPLFENII | GDIFPEVTVL | KVNQLALEKV | IYTATQQLGL | ||||
| QNWSSQKEKI | IQFYNQLQVC | VGVMLVGPTG | GGKTTVRRIL | EKALTLLPIA | ||||
| DFLSVAERKS | ASKISERKGK | VDICVLNPKC | VTLSELYGQL | DPNTMEWTDG | ||||
| LLSATIRSYV | YFNTPKNTKK | DIDLRLKSRI | SDLSNVFKLD | SSDTTETDDN | ||||
| IFEEIEKVVK | IPENHNFDWQ | WIILDGPVDT | FWVENLNSVL | DDTRTLCLAN | ||||
| SERIALTNKI | RVIFEVDNLS | QASPATVSRC | AMVYMDPVDL | GWEPYVKSWL | ||||
| LKTSKIISQS | GVDCLEFMIK | NSVTDGLQFI | RNRQKFQPYP | MEDITVVITL | ||||
| CRILDAFFDF | MGKNGGFEQS | DDLNDTSSKE | ANSQRESVTF | KDIEKRDENT | ||||
| WYPEKNPDKL | TKIIQKLFVF | AFTWAFGGAL | NREDEHRENI | PFCPSLEPDS | ||||
| LAKVTYDFDK | LVHELFGNSS | QVGINLPTGE | CSIFGYFVDI | EQCEFIPWSD | ||||
| LVPNDQTLIQ | RDNPTKKPEV | RTNKKLLKNN | DHKGVVVSTI | NFSTNVTAAK | ||||
| TKEMILKKLI | RRTKDTLGAP | KNNRILIFID | DMNMPVSDMY | GAQPPLELIR | ||||
| QLLDLGGVYD | TEKNTWKNIQ | DLSIVAACVP | VVNDISPRLL | KHFSMLVLPH | ||||
| PSQDILCTIF | QIGIDGCGKK | TCATLACYLT | DNKLYRVPIS | HKCAYIEFKE | ||||
| VFKKVFIHAG | LKGKPTVLMV | PNLNIEQDSF | LEDLNYIISS | GRIPDLFENV | ||||
| ELDSIAMKIR | YLTEQSGHMD | NRQSLLSFFQ | KRIYKNLHIF | VIMSPEGPSF | ||||
| RQNCRVYPSM | ISSCTIDWYE | RWPEEALLIV | ANSFLKEKVN | FENRENLKEK | ||||
| LAPTCVQIHK | SMKDLNRKYF | EETGRFYYTT | PNSYLQFMET | FAHILRAREE | ||||
| EMQTKRDRFH | MGLSTILEAT | TLVTEMQEEL | LILGPQVEQK | TKETETLMEK | ||||
| LRKDSQVVEK | VQMLVKQDEE | IVAEEVRIVE | DYAQKTANEL | KSVLPAFDKA | ||||
| IVALNALDKA | DVAELRVYTR | PPFLVLTVMN | AVCILLQKKP | NWATAKLLLS | ||||
| ETGFLKKLIN | LDKDSIPDKV | FVKLKKIVTL | PDFNPHKISL | VSVACCSLCQ | ||||
| WVIALNNYHE | VQKVVGPKQI | QVAEAQNVLK | IARQRLAEKQ | RGLQLISRWH | ||||
| NQGLPHGQYS | VENAILIKNG | QQWPLLIDPH | RQAHKWIRQM | EGSRLQKLSI | ||||
| EDSNYTKKIE | NAMKTGGSVL | LQSCQASTWR | KKLYLSTEID | NPHFLPSVYN | ||||
| FVTMINFTVT | FQGLQDQLLS | TVVTHEVPHL | EDQRSKLLES | ISLDAITLEE | ||||
| LEEKTLNLLQ | KALGSILDDD | KIVDTLRKSK | MTSNEISKRI | EATKKAESEI | ||||
| QAIRKNYLPI | ATRGALLYFL | VADLTQINYM | YQFSLDWFHQ | VFVSSVVSKS | ||||
| KEQEHSFKRE | KVSPKEVHEF | ISISKEPNLE | NEKNLLDKHI | KSAIDMLTKS | ||||
| IFKVVSSALF | NEDKLCFSFR | LCTVIMQNNA | NGNLIQDDIG | FLPEEEWNIF | ||||
| LYSGILINIK | SALSQSRLTS | TFEIGESQHL | QWLSDSRWRQ | CQYVSTHLEP | ||||
| FSLLCKSLLS | NVSQWDTFKN | SKAVYSLIST | PFSSENASLE | ENTKPPEEKH | ||||
| TFCLLLRAIN | HTGTDLGPVG | RGQWLTSTAC | DRHTDVCSFS | FALNDGVPDV | ||||
| EHVQDIFYGH | CVDKYHVKVL | RPESLNNSVR | KFITEKMGNK | YLQRTGVNLK | ||||
| DAYKGSNART | PLILIQTHGS | ASIKDYIHII | QSLPDDDLPE | VLGIHPEAIR | ||||
| SCWETQGEKF | IENLIAMQPK | TTTANLMIRP | EQSKDELVME | ILSDLLKRLP | ||||
| LTVEKEEIAV | GTPSTLKSMM | SSSIWESLSK | NLKDHDPLIH | CVLLTFLKQE | ||||
| IKRFDKLLFV | IHKSLKDLQL | AIKGEIILTQ | ELEEIFNSFL | NMRVPTLWQK | ||||
| HAYRSCKPLS | SWIDDLIQRL | NFFNTWAKVA | YTAIQRRYMR | FVTVWKQSIP | ||||
| STSQKCKHPE | DSENNFFEGF | PSRYWLPAFF | FPQAFLAAVL | QDYGRSRGIA | ||||
| VDALTFTHHV | ISNTTDKDEK | FSVFMPKKLN | IVRRAFKGSA | SSHTGVYIFG | ||||
| LFIEGARWNR | EQKILEDSLP | LEMCCDFPDI | YFLPTKISTK | TPNASNQTDS | ||||
| ELYAFECPVY | QTPERSRILA | TTGLPTNFLT | SVYLSTKKPP | SHWITMRVAL | ||||
| LCEKNEK |
Funkcija
urediDineini su proteinski kompleksi motornih proteina, povezanih s mikrotubulama, sastavljeni od nekoliko teških, lahkih i srednjeteških lanaca. Identificirane su dvije glavne klase dineina: aksonski i citoplazmatski. DNAH14 je aksonemski teški lanac dineina (DHC) (Vaughan et al., 1996 PubMed 8812413]).[7]
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000185842 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047369 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Dynein, axonemal, heavy chain 14".
- ^ "UniProt, Q0VDD8" (jezik: en.). Pristupljeno 9. 12. 2021.CS1 održavanje: nepoznati jezik (link)
- ^ Vaughan KT, Mikami A, Paschal BM, Holzbaur EL, Hughes SM, Echeverri CJ, Moore KJ, Gilbert DJ, Copeland NG, Jenkins NA, Vallee RB (august 1996). "Multiple mouse chromosomal loci for dynein-based motility". Genomics. 36 (1): 29–38. doi:10.1006/geno.1996.0422. PMID 8812413.
Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.