Diacilglicerol O-aciltransferaza 2 (DGAT2) je proteinenzim koji je kod ljudi kodiran genom DGAT2.[5]

DGAT2
Identifikatori
AliasiDGAT2
Vanjski ID-jeviOMIM: 606983 MGI: 1915050 HomoloGene: 23580 GeneCards: DGAT2
EC broj2.3.1.76
Lokacija gena (čovjek)
Hromosom 11 (čovjek)
Hrom.Hromosom 11 (čovjek)[1]
Hromosom 11 (čovjek)
Genomska lokacija za DGAT2
Genomska lokacija za DGAT2
Bend11q13.5Početak75,759,512 bp[1]
Kraj75,801,535 bp[1]
Lokacija gena (miš)
Hromosom 7 (miš)
Hrom.Hromosom 7 (miš)[2]
Hromosom 7 (miš)
Genomska lokacija za DGAT2
Genomska lokacija za DGAT2
Bend7|7 E1Početak98,802,865 bp[2]
Kraj98,831,926 bp[2]
Ontologija gena
Molekularna funkcija protein homodimerization activity
acyltransferase activity, transferring groups other than amino-acyl groups
acyltransferase activity
2-acylglycerol O-acyltransferase activity
retinol O-fatty-acyltransferase activity
aktivnost sa transferazom
diacylglycerol O-acyltransferase activity
Ćelijska komponenta integral component of membrane
intracellular membrane-bounded organelle
Lipidna kapljica
perinuklearno područje citoplazme
integral component of endoplasmic reticulum membrane
membrana
Endoplazmatski retikulum
endoplasmic reticulum membrane
mitohondrija
Biološki proces regulation of cholesterol metabolic process
lipid storage
long-chain fatty-acyl-CoA metabolic process
positive regulation of gluconeogenesis
fat pad development
cellular response to oleic acid
fatty acid homeostasis
positive regulation of triglyceride biosynthetic process
lipid metabolism
regulation of plasma lipoprotein particle levels
negative regulation of fatty acid oxidation
acylglycerol acyl-chain remodeling
retinol metabolic process
low-density lipoprotein particle clearance
glycerol metabolic process
diacylglycerol metabolic process
cellular triglyceride homeostasis
cholesterol homeostasis
regulation of lipoprotein metabolic process
triglyceride biosynthetic process
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001253891
NM_032564

NM_026384

RefSeq (bjelančevina)

NP_001240820
NP_115953

NP_080660

Lokacija (UCSC)Chr 11: 75.76 – 75.8 MbChr 7: 98.8 – 98.83 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 388 aminokiselina, a molekulska težina 43.831 Da.[6]

1020304050
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSAL
QDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCW
LIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNL
LTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFR
MPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPG
KNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHP
TQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN

Funkcija

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Ovaj gen kodira jedan od dva enzima koji kataliziraju konačnu reakciju u sintezi triglicerida, u kojoj je diacilglicerol kovalentno vezan za masu dugog lanca acil-CoAs.

Kodirani protein katalizira ovu reakciju pri niskim koncentracijama magnezij-hlorida, dok drugi enzim ima visoku aktivnost pri visokim koncentracijama magnezij-hlorida. Za ovaj gen je pronađeno više varijanti transkripta koje kodiraju različite izoforme.

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000062282 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030747 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Diacylglycerol O-acyltransferase 2". Pristupljeno 18. 7. 2017.
  6. ^ "UniProt, Q96PD7". Pristupljeno 20. 8. 2021.

Dopunska literatura

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Vanjski linkovi

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