DDX31

DEAD (Asp-Glu-Ala-Asp) kutijski polipeptid 31, znan i kao DDX31, je ljudski gen.

DDX31
Identifikatori
Aliasi	DDX31
Vanjski ID-jevi	OMIM: 616533 MGI: 2682639 HomoloGene: 6389 GeneCards: DDX31
Lokacija gena (čovjek) Hrom. Hromosom 9 (čovjek) Bend 9q34.13 Početak 132,592,997 bp Kraj 132,670,401 bp
Lokacija gena (miš) Hrom. Hromosom 2 (miš) Bend 2|2 A3 Početak 28,730,418 bp Kraj 28,795,583 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • nucleotide binding • GO:0001948, GO:0016582 vezivanje za proteine • hydrolase activity • ATP binding • GO:0008026 helicase activity • nucleic acid binding • vezivanje sa RNK Ćelijska komponenta • Golđijev aparat • intracellular membrane-bounded organelle • jedro • Jedarce • citoplazma Biološki proces • ribosome biogenesis • RNA secondary structure unwinding Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	64794	227674
Ensembl	ENSG00000125485	ENSMUSG00000026806
UniProt	Q9H8H2	Q6NZQ2
RefSeq (mRNK)	NM_022779 NM_138620 NM_001322340 NM_001322341 NM_001322342 NM_001322343 NM_001322344	NM_001033294
RefSeq (bjelančevina)	NP_001309269 NP_001309270 NP_001309271 NP_001309272 NP_001309273 NP_073616 NP_619526	NP_001028466
Lokacija (UCSC)	Chr 9: 132.59 – 132.67 Mb	Chr 2: 28.73 – 28.8 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

DEAD-kutijski proteini, koje karakterizira konzervirani motivAsp-Glu-Ala-Asp (DEAD), pretpostavljene su RNK helikaze. Uključeni su u brojne ćelijske procese koji uključuju promjenu sekundarne strukture RNK, kao što su inicijacija translacija, jedarna i mitohondrijska orerada i sklapanje ribosoma i splajsosoma. Na osnovu njihovih obrazaca distribucije, vjeruje se da su neki članovi ove porodice proteina iz DEAD-kutije uključeni u embriogenezu, spermatogenezu i ćelijski rast i diobu. Ovaj gen kodira člana ove porodice. Funkcija ovog člana nije utvrđena. Alternativna prerada ovog gena generira dvije varijante transkripta.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 851 aminokiselina, а molekulska težina 94.087 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MAPDLASQRH		SESFPSVNSR		PNVILPGREG		RREGLPPGGG		TRGSLVPTRP
VPPSPAPLGT		SPYSWSRSGP		GRGGGAGSSR		VPRGVPGPAV		CAPGSLLHHA
SPTQTMAAAD		GSLFDNPRTF		SRRPPAQASR		QAKATKRKYQ		ASSEAPPAKR
RNETSFLPAK		KTSVKETQRT		FKGNAQKMFS		PKKHSVSTSD		RNQEERQCIK
TSSLFKNNPD		IPELHRPVVK		QVQEKVFTSA		AFHELGLHPH		LISTINTVLK
MSSMTSVQKQ		SIPVLLEGRD		ALVRSQTGSG		KTLAYCIPVV		QSLQAMESKI
QRSDGPYALV		LVPTRELALQ		SFDTVQKLLK		PFTWIVPGVL		MGGEKRKSEK
ARLRKGINIL		ISTPGRLVDH		IKSTKNIHFS		RLRWLVFDEA		DRILDLGFEK
DITVILNAVN		AECQKRQNVL		LSATLTEGVT		RLADISLHDP		VSISVLDKSH
DQLNPKDKAV		QEVCPPPAGD		KLDSFAIPES		LKQHVTVVPS		KLRLVCLAAF
ILQKCKFEED		QKMVVFFSSC		ELVEFHYSLF		LQTLLSSSGA		PASGQLPSAS
MRLKFLRLHG		GMEQEERTAV		FQEFSHSRRG		VLLCTDVAAR		GLDLPQVTWI
VQYNAPSSPA		EYIHRIGRTA		RIGCHGSSLL		ILAPSEAEYV		NSLASHKINV
SEIKMEDILC		VLTRDDCFKG		KRWGAQKSHA		VGPQEIRERA		TVLQTVFEDY
VHSSERRVSW		AKKALQSFIQ		AYATYPRELK		HIFHVRSLHL		GHVAKSFGLR
DAPRNLSALT		RKKRKAHVKR		PDLHKKTQSK		HSLAEILRSE		YSSGMEADIA
KVKKQNAPGE		PGGRPLQHSL		QPTPCFGRGK		TLKWRKTQKG		VQRDSKTSQK
V

Dopunska literatura

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Abdelhaleem M, Maltais L, Wain H (2004). "The human DDX and DHX gene families of putative RNA helicases". Genomics. 81 (6): 618–22. doi:10.1016/S0888-7543(03)00049-1. PMID 12782131.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.