CYTL1

CYTL1
Identifikatori
Aliasi	CYTL1
Vanjski ID-jevi	OMIM: 607930 MGI: 2684993 HomoloGene: 10254 GeneCards: CYTL1
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	5,019,458 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	37,897,164 bp
Ontologija gena
Molekularna funkcija	• signaling receptor binding;
Ćelijska komponenta	• extracellular region; • Vanćelijsko;
Biološki proces	• inner ear development; • chondroitin sulfate proteoglycan biosynthetic process; • positive regulation of DNA-binding transcription factor activity; • cartilage homeostasis; • chondrocyte differentiation; • GO:0072468 Transdukcija signala; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	54360
	231162
	ENSG00000170891
	ENSMUSG00000062329
	Q9NRR1
	A1E5L0
	NM_018659
	NM_001081106
	NP_061129
	NP_001074575
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Citokinoliki protein 1 (CYTL1) jest protein koji je kod ljudi kodiran genom CYTL1 sa hromosoma 4.^[5]

Aminokiselinska sekvenca uredi

C17 je protein sličan citokinu koji je specifično eksprimiran u koštanoj srži i krvi pupčane vrpce, monojedarni ćelijama koje nose površinski marker CD34.^[7] Funkcionalno , C17 je identificiran kao sekretorni protein eksprimiran u CD34 i hemopoetskim ćelijama.^[7] CYTL1 regulira hondrogenezu i potreban je za održavanje homeostaze hrskavice i može, dodatno, djelovati kao regulatorni faktor u implantaciji embriona u fazi rane trudnoće.^[8]

Proteini ove porodice, C17, nalazi se u kičmenjacima. Proteini imaju dva konzervirana motiva sekvence: PPTCYSR i DDC.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170891 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000062329 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Cytokine-like 1".
^ "UniProt, Q9NRR1" (jezik: engleski). Pristupljeno 25. 10. 2021.
^ ^a ^b Liu X, Rapp N, Deans R, Cheng L (maj 2000). "Molecular cloning and chromosomal mapping of a candidate cytokine gene selectively expressed in human CD34+ cells". Genomics. 65 (3): 283–92. doi:10.1006/geno.2000.6170. PMID 10857752.
^ Ai Z, Jing W, Fang L (2016). "Cytokine-Like Protein 1(Cytl1): A Potential Molecular Mediator in Embryo Implantation". PLOS ONE. 11 (1): e0147424. Bibcode:2016PLoSO..1147424A. doi:10.1371/journal.pone.0147424. PMC 4723121. PMID 26800213.

Deng X, Zhao HS, Peng Z, Deng WW, Li N, Guo S, Shi TP (april 2011). "[Study on the mechanism of C17orf62 induced cell death]". Beijing da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences. 43 (2): 168–72. PMID 21503106.
Tomczak A, Pisabarro MT (april 2011). "Identification of CCR2-binding features in Cytl1 by a CCL2-like chemokine model". Proteins. 79 (4): 1277–92. doi:10.1002/prot.22963. PMID 21322034. S2CID 24312749.
Chao C, Joyce-Shaikh B, Grein J, Moshrefi M, Raoufi F, Laface DM, McClanahan TK, Bourne PA, Pierce RH, Gorman DM, Pflanz S (2011). "C17 prevents inflammatory arthritis and associated joint destruction in mice". PLOS ONE. 6 (7): e22256. Bibcode:2011PLoSO...622256C. doi:10.1371/journal.pone.0022256. PMC 3143151. PMID 21799806.
Chen XD, Xiong DH, Yang TL, Pei YF, Guo YF, Li J, Yang F, Pan F, Tan LJ, Yan H, Liu XG, Lei SF, Li X, Ning LL, Zhu XZ, Levy S, Kranzler HR, Farrer LA, Gelernter J, Recker RR, Deng HW (mart 2012). "ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior". Chinese Medical Journal. 125 (6): 1127–34. PMC 4174677. PMID 22613542.
Kwon YJ, Lee SJ, Koh JS, Kim SH, Lee HW, Kang MC, Bae JB, Kim YJ, Park JH (januar 2012). "Genome-wide analysis of DNA methylation and the gene expression change in lung cancer". Journal of Thoracic Oncology. 7 (1): 20–33. doi:10.1097/JTO.0b013e3182307f62. PMID 22011669.