CXCL13

CXCL13
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4ZAI, 5CBA, 5CBE
Identifikatori
Aliasi	CXCL13
Vanjski ID-jevi	OMIM: 605149 MGI: 1888499 HomoloGene: 48431 GeneCards: CXCL13
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	77,611,834 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	96,108,927 bp
Ontologija gena
Molekularna funkcija	• receptor ligand activity; • CCR10 chemokine receptor binding; • cytokine activity; • heparin binding; • CXCR3 chemokine receptor binding; • chemokine activity; • protein heterodimerization activity; • fibroblast growth factor binding; • CXCR5 chemokine receptor binding;
Ćelijska komponenta	• extracellular region; • Vanćelijsko;
Biološki proces	• chemokine-mediated signaling pathway; • positive regulation of cytosolic calcium ion concentration; • cell-cell signaling; • germinal center formation; • regulation of angiogenesis; • Hemotaksija; • endothelial cell chemotaxis to fibroblast growth factor; • regulation of humoral immune response; • cell surface receptor signaling pathway; • response to lipopolysaccharide; • regulation of cell population proliferation; • defense response to bacterium; • negative regulation of endothelial cell chemotaxis to fibroblast growth factor; • positive regulation of T cell chemotaxis; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor; • inflammatory response; • chronic inflammatory response; • defense response; • antimicrobial humoral immune response mediated by antimicrobial peptide; • regulation of signaling receptor activity; • G protein-coupled receptor signaling pathway; • lymphocyte chemotaxis across high endothelial venule; • positive regulation of integrin activation; • positive regulation of cell-cell adhesion mediated by integrin; • B cell chemotaxis; • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity; • neutrophil chemotaxis; • leukocyte chemotaxis; • cellular response to lipopolysaccharide;
	Izvori:Amigo / QuickGO
Ortolozi
	10563
	55985
	ENSG00000156234
	ENSMUSG00000023078
	O43927
	O55038
	NM_006419; NM_001371558
	NM_018866
	NP_006410; NP_001358487
	NP_061354
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Hemokinski ligand 13 (C-X-C motiv), znan i kao B-lmfocitni hemoatraktant (BLC) ili B-ćelijski atraktantski hemokin 1 (BCA-1), jest citokinski protein koji je kod ljudi kodiran genom CXCL13 sa hromosoma 4.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 109 aminokiselina, а molekulska težina 12.664 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MKFISTSLLL	MLLVSSLSPV	QGVLEVYYTS	LRCRCVQESS	VFIPRRFIDR
IQILPRGNGC	PRKEIIVWKK	NKSIVCVDPQ	AEWIQRMMEV	LRKRSSSTLP
VPVFKRKIP

Funkcija

CXCL13 je mali hemokin koji pripada porodici hemokina CXC. Kao što mu druga imena sugerrajuu, ovaj hemokin ima selektivne hemotaksije za B-ćelije u koje pripadaju i B-1 i B -2 podskupine i izaziva njegove učinke interakcijom s hemokinskim receptorom CXCR5.^[5]^[8] CXCL13 i njegov receptor CXCR5 kontroliraju organizaciju B-ćelija unutar folikula limfoidnih tkiva^[9] i izrazito je eksprimiran u ljudskoj jetri, slezeni, limfnim čvorovima i crijevima.^[5] Na ljudskom hromosomu 4 gen za CXCL13 nalazi se u grupi gena drugih CXC hemokina.^[6]

Smatra se da u T-limfocitima ekspresija CXCL13 odražava klicino središte T-ćelija, posebno podskupa T-ćelija koji se naziva folikulne B-pomoćne T-ćelije (ili T_FH ćelije). Stoga se smatra da ekspresija CXCL13 u T-ćelijskim limfomima, kao što je angioimunoblastni T-ćelijski limfom, odražava porijeklo neoplazijskih T-ćelija iz klicinog centra.^[10]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000156234 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023078 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Legler DF, Loetscher M, Roos RS, Clark-Lewis I, Baggiolini M, Moser B (februar 1998). "B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5". J. Exp. Med. 187 (4): 655–60. doi:10.1084/jem.187.4.655. PMC 2212150. PMID 9463416.
^ ^a ^b Gunn MD, Ngo VN, Ansel KM, Ekland EH, Cyster JG, Williams LT (februar 1998). "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1". Nature. 391 (6669): 799–803. doi:10.1038/35876. PMID 9486651. S2CID 4373691.
^ "UniProt, O43927" (jezik: engleski). Pristupljeno 24. 10. 2021.
^ Ansel KM, Harris RB, Cyster JG (januar 2002). "CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity". Immunity. 16 (1): 67–76. doi:10.1016/S1074-7613(01)00257-6. PMID 11825566.
^ Ansel KM, Ngo VN, Hyman PL, Luther SA, Förster R, Sedgwick JD, Browning JL, Lipp M, Cyster JG (juli 2000). "A chemokine-driven positive feedback loop organizes lymphoid follicles". Nature. 406 (6793): 309–14. doi:10.1038/35018581. PMID 10917533. S2CID 4369622.
^ de Leval L, Rickman DS, Thielen C, Reynies A, Huang YL, Delsol G, Lamant L, Leroy K, Brière J, Molina T, Berger F, Gisselbrecht C, Xerri L, Gaulard P (juni 2007). "The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells". Blood. 109 (11): 4952–63. doi:10.1182/blood-2006-10-055145. PMID 17284527.

Vanjski linkovi

Lokacija ljudskog genoma CXCL13 i stranica sa detaljima o genu CXCL13 u UCSC Genome Browseru.
O43927

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000156234 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023078 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9463416-5] Legler DF, Loetscher M, Roos RS, Clark-Lewis I, Baggiolini M, Moser B (februar 1998). "B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5". J. Exp. Med. 187 (4): 655–60. doi:10.1084/jem.187.4.655. PMC 2212150. PMID 9463416.

[pmid9486651-6] Gunn MD, Ngo VN, Ansel KM, Ekland EH, Cyster JG, Williams LT (februar 1998). "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1". Nature. 391 (6669): 799–803. doi:10.1038/35876. PMID 9486651. S2CID 4373691.

[UniProt-7] "UniProt, O43927" (jezik: engleski). Pristupljeno 24. 10. 2021.

[pmid11825566-8] Ansel KM, Harris RB, Cyster JG (januar 2002). "CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity". Immunity. 16 (1): 67–76. doi:10.1016/S1074-7613(01)00257-6. PMID 11825566.

[pmid10917533-9] Ansel KM, Ngo VN, Hyman PL, Luther SA, Förster R, Sedgwick JD, Browning JL, Lipp M, Cyster JG (juli 2000). "A chemokine-driven positive feedback loop organizes lymphoid follicles". Nature. 406 (6793): 309–14. doi:10.1038/35018581. PMID 10917533. S2CID 4369622.

[pmid17284527-10] Leval L, Rickman DS, Thielen C, Reynies A, Huang YL, Delsol G, Lamant L, Leroy K, Brière J, Molina T, Berger F, Gisselbrecht C, Xerri L, Gaulard P (juni 2007). "The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells". Blood. 109 (11): 4952–63. doi:10.1182/blood-2006-10-055145. PMID 17284527.

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