CTRC1

Kolagenski trostruki heliks sa ponavljanjem 1 je protein koji je kod ljudi kodiran genom CTHRC1.

CTRC1
Identifikatori
Aliasi	CTHRC1
Vanjski ID-jevi	OMIM: 610635 MGI: 1915838 HomoloGene: 16320 GeneCards: CTHRC1
Lokacija gena (čovjek) Hrom. Hromosom 8 (čovjek) Bend 8q22.3 Početak 103,371,538 bp Kraj 103,382,989 bp
Lokacija gena (miš) Hrom. Hromosom 15 (miš) Bend 15|15 B3.1 Početak 38,940,327 bp Kraj 38,950,516 bp
Ontologija gena Molekularna funkcija • Wnt-protein binding • GO:0005110 frizzled binding • extracellular matrix structural constituent Ćelijska komponenta • citoplazma • collagen • Vanćelijsko • extracellular region • GO:0005578 Vanćelijski matriks • collagen-containing extracellular matrix Biološki proces • Wnt signaling pathway, planar cell polarity pathway • positive regulation of osteoblast proliferation • positive regulation of protein binding • positive regulation of osteoblast differentiation • Ćelijska migracija • inner ear receptor cell stereocilium organization • negative regulation of canonical Wnt signaling pathway • cochlea morphogenesis • establishment of planar polarity involved in neural tube closure • ossification involved in bone remodeling Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	115908	68588
Ensembl	ENSG00000164932	ENSMUSG00000054196
UniProt	Q96CG8	Q9D1D6
RefSeq (mRNK)	NM_001256099 NM_138455	NM_026778 NM_001364812 NM_001364813
RefSeq (bjelančevina)	NP_001243028 NP_612464	NP_081054 NP_001351741 NP_001351742
Lokacija (UCSC)	Chr 8: 103.37 – 103.38 Mb	Chr 15: 38.94 – 38.95 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 243 aminokiseline, а molekulska težina 26.224 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MRPQGPAASP		QRLRGLLLLL		LLQLPAPSSA		SEIPKGKQKA		QLRQREVVDL
YNGMCLQGPA		GVPGRDGSPG		ANGIPGTPGI		PGRDGFKGEK		GECLRESFEE
SWTPNYKQCS		WSSLNYGIDL		GKIAECTFTK		MRSNSALRVL		FSGSLRLKCR
NACCQRWYFT		FNGAECSGPL		PIEAIIYLDQ		GSPEMNSTIN		IHRTSSVEGL
CEGIGAGLVD		VAIWVGTCSD		YPKGDASTGW		NSVSRIIIEE		LPK

Funkcija

Ovaj lokus kodira protein koji može imati ulogu u ćelijskom odgovoru na povredu arterija uključivanjem u vaskularno remodeliranje. Mutacije na ovom lokusu su povezane sa poremećajem zvanim Barrettov jednjak i adenokarcinom jednjaka. Opisane su alternativno prerađene varijante transkripta.

Dopunska literatura

• Pyagay P, Heroult M, Wang Q, Lehnert W, Belden J, Liaw L, Friesel RE, Lindner V (2005). "Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration". Circ. Res. 96 (2): 261–8. doi:10.1161/01.RES.0000154262.07264.12. PMID 15618538.
• Tang L, Dai DL, Su M, Martinka M, Li G, Zhou Y (2006). "Aberrant expression of collagen triple helix repeat containing 1 in human solid cancers". Clin. Cancer Res. 12 (12): 3716–22. doi:10.1158/1078-0432.CCR-06-0030. PMID 16778098.
• Leclair RJ, Wang Q, Benson MA, Prudovsky I, Lindner V (2008). "Intracellular localization of Cthrc1 characterizes differentiated smooth muscle". Arterioscler. Thromb. Vasc. Biol. 28 (7): 1332–8. doi:10.1161/ATVBAHA.108.166579. PMC 3508505. PMID 18467647.
• Landa I, Ruiz-Llorente S, Montero-Conde C, Inglada-Pérez L, Schiavi F, Leskelä S, Pita G, Milne R, Maravall J, Ramos I, Andía V, Rodríguez-Poyo P, Jara-Albarrán A, Meoro A, del Peso C, Arribas L, Iglesias P, Caballero J, Serrano J, Picó A, Pomares F, Giménez G, López-Mondéjar P, Castello R, Merante-Boschin I, Pelizzo MR, Mauricio D, Opocher G, Rodríguez-Antona C, González-Neira A, Matías-Guiu X, Santisteban P, Robledo M (2009). "The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors". PLOS Genet. 5 (9): e1000637. doi:10.1371/journal.pgen.1000637. PMC 2727793. PMID 19730683.
• Orloff M, Peterson C, He X, Ganapathi S, Heald B, Yang YR, Bebek G, Romigh T, Song JH, Wu W, David S, Cheng Y, Meltzer SJ, Eng C (2011). "Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma". JAMA. 306 (4): 410–9. doi:10.1001/jama.2011.1029. PMC 3574553. PMID 21791690.
• Wang P, Wang YC, Chen XY, Shen ZY, Cao H, Zhang YJ, Yu J, Zhu JD, Lu YY, Fang JY (2012). "CTHRC1 is upregulated by promoter demethylation and transforming growth factor-β1 and may be associated with metastasis in human gastric cancer". Cancer Sci. 103 (7): 1327–33. doi:10.1111/j.1349-7006.2012.02292.x. PMC 7659176. PMID 22590977. S2CID 2295293.
• Park EH, Kim S, Jo JY, Kim SJ, Hwang Y, Kim JM, Song SY, Lee DK, Koh SS (2013). "Collagen triple helix repeat containing-1 promotes pancreatic cancer progression by regulating migration and adhesion of tumor cells". Carcinogenesis. 34 (3): 694–702. doi:10.1093/carcin/bgs378. PMID 23222813.
• Spector I, Zilberstein Y, Lavy A, Genin O, Barzilai-Tutsch H, Bodanovsky A, Halevy O, Pines M (2013). "The involvement of collagen triple helix repeat containing 1 in muscular dystrophies". Am. J. Pathol. 182 (3): 905–16. doi:10.1016/j.ajpath.2012.11.004. PMID 23274062.
• Tan F, Liu F, Liu H, Hu Y, Liu D, Li G (2013). "CTHRC1 is associated with peritoneal carcinomatosis in colorectal cancer: a new predictor for prognosis". Med. Oncol. 30 (1): 473. doi:10.1007/s12032-013-0473-3. PMID 23359115. S2CID 36232939.