CRYZL1

CRYZL1
Identifikatori
Aliasi	CRYZL1
Vanjski ID-jevi	OMIM: 603920 MGI: 1913859 HomoloGene: 3749 GeneCards: CRYZL1
Lokacija gena (čovjek)
Hrom.	Hromosom 21 (čovjek)
Kraj	33,643,926 bp
Lokacija gena (miš)
Hrom.	Hromosom 16 (miš)
Kraj	91,525,863 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• oxidoreductase activity; • NADP binding; • NADPH:quinone reductase activity;
Ćelijska komponenta	• citosol;
Biološki proces	• quinone metabolic process;
	Izvori:Amigo / QuickGO
Ortolozi
	9946
	66609
	ENSG00000205758
	ENSMUSG00000058240
	O95825
	Q921W4
	NM_145858; NM_145311
	NM_026994; NM_133679
	NP_665857
	NP_081270; NP_598440
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Oksidoreduktazoliki kinonski protein 1 jest enzim koji je kod ljudi kodiran genom CRYZL1 sa hromosoma 21.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 349 aminokiselina, a molekulska težina 38.697 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MKGLYFQQSS	TDEEITFVFQ	EKEDLPVTED	NFVKLQVKAC	ALSQINTKLL
AEMKMKKDLF	PVGREIAGIV	LDVGSKVSFF	QPDDEVVGIL	PLDSEDPGLC
EVVRVHEHYL	VHKPEKVTWT	EAAGSIRDGV	RAYTALHYLS	HLSPGKSVLI
MDGASAFGTI	AIQLAHHRGA	KVISTACSLE	DKQCLERFRP	PIARVIDVSN
GKVHVAESCL	EETGGLGVDI	VLDAGVRLYS	KDDEPAVKLQ	LLPHKHDIIT
LLGVGGHWVT	TEENLQLDPP	DSHCLFLKGA	TLAFLNDEVW	NLSNVQQGKY
LCILKDVMEK	LSTGVFRPQL	DEPIPLYEAK	VSMEAVQKNQ	GRKKQVVQF

Funkcija

Ovaj gen kodira protein koji ima sličnu sekvencu sa zeta kristalinom, također poznatim kao kinon-oksidoreduktaza. Ovaj protein sličan zeta kristalinu takođe sadrži NAD(P)H mjesto vezivanja. Uočene su alternativno prerađene varijante transkripta, ali priroda njihove pune dužine nije u potpunosti utvrđena.^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000205758 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058240 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kim MY, Lee HK, Park JS, Park SH, Kwon HB, Soh J (Jun 1999). "Identification of a zeta-crystallin (quinone reductase)-like 1 gene (CRYZL1) mapped to human chromosome 21q22.1". Genomics. 57 (1): 156–9. doi:10.1006/geno.1998.5714. PMID 10191096.
^ ^a ^b ^c "Entrez Gene: CRYZL1 crystallin, zeta (quinone reductase)-like 1".

Dopunska literatura

Mount SM (2000). "Genomic Sequence, Splicing, and Gene Annotation". Am. J. Hum. Genet. 67 (4): 788–92. doi:10.1086/303098. PMC 1287883. PMID 10986039.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
Fernández MR, Porté S, Crosas E, et al. (2007). "Human and yeast zeta-crystallins bind AU-rich elements in RNA". Cell. Mol. Life Sci. 64 (11): 1419–27. doi:10.1007/s00018-007-7091-1. PMID 17497241. S2CID 2165411.

Vanjski linkovi

Lokacija ljudskog genoma CRYZL1 i stranica sa detaljima o genu CRYZL1 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000205758 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058240 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10191096-5] Kim MY, Lee HK, Park JS, Park SH, Kwon HB, Soh J (Jun 1999). "Identification of a zeta-crystallin (quinone reductase)-like 1 gene (CRYZL1) mapped to human chromosome 21q22.1". Genomics. 57 (1): 156–9. doi:10.1006/geno.1998.5714. PMID 10191096.

[entrez-6] "Entrez Gene: CRYZL1 crystallin, zeta (quinone reductase)-like 1".

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