CPEB1

Citoplazmatski poliadenilacijski element sa vezanim proteinom 1 jest protein koji je kod ljudi kodiran genom CPEB1.

CPEB1
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2M13, 2MKH, 2MKK, 2N1O
Identifikatori
Aliasi	CPEB1
Vanjski ID-jevi	OMIM: 607342 MGI: 108442 HomoloGene: 7278 GeneCards: CPEB1
Lokacija gena (čovjek) Hrom. Hromosom 15 (čovjek) Bend 15q25.2 Početak 82,543,201 bp Kraj 82,648,861 bp
Lokacija gena (miš) Hrom. Hromosom 7 (miš) Bend 7|7 D3 Početak 80,996,774 bp Kraj 81,105,213 bp
Ontologija gena Molekularna funkcija • vezivanje iona metala • mRNA 3'-UTR AU-rich region binding • translation factor activity, RNA binding • vezivanje sa RNK • nucleic acid binding • ribosome binding • translation repressor activity, mRNA regulatory element binding • mRNA 3'-UTR binding • translation regulator activity • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • sinapsa • projekcija ćelije • međućelijske veze • neuron projection • messenger ribonucleoprotein complex • GO:0097483, GO:0097481 postsynaptic density • postsynaptic membrane • membrana • P-tijelo • dendrit • ćelijska membrana • citoplazma • jedro • nukleoplazma • citosol Biološki proces • cellular response to insulin stimulus • regulation of translation • negative regulation of cytoplasmic translation • mRNA processing • cellular response to amino acid stimulus • cellular response to hypoxia • Biosinteza bjelančevina • positive regulation of mRNA polyadenylation Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	64506	12877
Ensembl	ENSG00000277445 ENSG00000214575	ENSMUSG00000025586
UniProt	Q9BZB8	P70166
RefSeq (mRNK)	NM_030594 NM_001079533 NM_001079534 NM_001079535 NM_001288819 NM_001288820	NM_001252525 NM_001252526 NM_007755 NM_001357107
RefSeq (bjelančevina)	NP_001073001 NP_001073002 NP_001073003 NP_001275748 NP_001275749 NP_085097 NP_001352169 NP_001352170 NP_001352171 NP_001352172 NP_001352173 NP_001352174 NP_001352175 NP_001352176 NP_001352177 NP_001352178 NP_001352179	NP_001239454 NP_001239455 NP_031781 NP_001344036
Lokacija (UCSC)	Chr 15: 82.54 – 82.65 Mb	Chr 7: 81 – 81.11 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Ovaj gen kodira člana citoplazmatskog elementa poliadenilacije (CPE) koji se veže porodicu proteina. Ovaj visoko konzervirani protein vezuje se za specifičnu sekvencu RNK koja se naziva CPE, u 3'UTR nekih iRNK. Slični proteini u žabljem rodu Xenopus i miševima funkcioniraju da indukuju citoplazmatsku poliadenilaciju utišanih iRNK s kratkim poliA repovima, što rezultira njihovim translacijama. Članovi ove porodice proteina regulišu translaciju ciklina B1 tokom embrionskih ćelijskih dioba. Za ovaj gen je pronađeno više transkripata, varijanti koje kodiraju različite izoforme.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 566 aminokiselina, a molekulska težina 62.595 Da..

10		20		30		40		50
MALSLEEEAG		RIKDCWDNQE		APALSTCSNA		NIFRRINAIL		DNSLDFSRVC
TTPINRGIHD		HLPDFQDSEE		TVTSRMLFPT		SAQESSRGLP		DANDLCLGLQ
SLSLTGWDRP		WSTQDSDSSA		QSSTHSVLSM		LHNPLGNVLG		KPPLSFLPLD
PLGSDLVDKF		PAPSVRGSRL		DTRPILDSRS		SSPSDSDTSG		FSSGSDHLSD
LISSLRISPP		LPFLSLSGGG		PRDPLKMGVG		SRMDQEQAAL		AAVTPSPTSA
SKRWPGASVW		PSWDLLEAPK		DPFSIEREAR		LHRQAAAVNE		ATCTWSGQLP
PRNYKNPIYS		CKVFLGGVPW		DITEAGLVNT		FRVFGSLSVE		WPGKDGKHPR
CPPKGNMPKG		YVYLVFELEK		SVRSLLQACS		HDPLSPDGLS		EYYFKMSSRR
MRCKEVQVIP		WVLADSNFVR		SPSQRLDPSR		TVFVGALHGM		LNAEALAAIL
NDLFGGVVYA		GIDTDKHKYP		IGSGRVTFNN		QRSYLKAVSA		AFVEIKTTKF
TKKVQIDPYL		EDSLCHICSS		QPGPFFCRDQ		VCFKYFCRSC		WHWRHSMEGL
RHHSPLMRNQ		KNRDSS

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Dopunska literatura

• Mendez R, Richter JD (2001). "Translational control by CPEB: a means to the end". Nat. Rev. Mol. Cell Biol. 2 (7): 521–9. doi:10.1038/35080081. PMID 11433366.
• "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Huang YS, Carson JH, Barbarese E, Richter JD (2003). "Facilitation of dendritic mRNA transport by CPEB". Genes Dev. 17 (5): 638–53. doi:10.1101/gad.1053003. PMC 196011. PMID 12629046.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wilczynska A, Aigueperse C, Kress M, et al. (2005). "The translational regulator CPEB1 provides a link between dcp1 bodies and stress granules". J. Cell Sci. 118 (Pt 5): 981–92. doi:10.1242/jcs.01692. PMID 15731006.
• Sasayama T, Marumoto T, Kunitoku N, et al. (2005). "Over-expression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1". Genes Cells. 10 (7): 627–38. doi:10.1111/j.1365-2443.2005.00870.x. PMID 15966895.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

Vanjski linkovi

• Lokacija ljudskog genoma CPEB1 i stranica sa detaljima o genu CPEB1 u UCSC Genome Browseru.