Oligomerni protein hrskavičnog matriksa (COMP), poznat i kao trombospondin-5, prvenstveno je protein vanćelijskog matriksa (ECM) prisutan u hrskavicama. Kod ljudi je kodiran je genom COMP.[5][6][7]

COMP
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

3FBY

Identifikatori
AliasiCOMP
Vanjski ID-jeviOMIM: 600310 MGI: 88469 HomoloGene: 74 GeneCards: COMP
Lokacija gena (čovjek)
Hromosom 19 (čovjek)
Hrom.Hromosom 19 (čovjek)[1]
Hromosom 19 (čovjek)
Genomska lokacija za COMP
Genomska lokacija za COMP
Bend19p13.11Početak18,782,773 bp[1]
Kraj18,791,305 bp[1]
Lokacija gena (miš)
Hromosom 8 (miš)
Hrom.Hromosom 8 (miš)[2]
Hromosom 8 (miš)
Genomska lokacija za COMP
Genomska lokacija za COMP
Bend8 B3.3|8 34.15 cMPočetak70,826,208 bp[2]
Kraj70,834,716 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija protease binding
calcium ion binding
heparan sulfate proteoglycan binding
heparin binding
extracellular matrix structural constituent
GO:0001948, GO:0016582 vezivanje za proteine
collagen binding
integrin binding
BMP binding
proteoglycan binding
Ćelijska komponenta GO:0005578 Vanćelijski matriks
Egzosom
Vanćelijsko
extracellular region
GO:0009327 makromolekulani kompleks
collagen-containing extracellular matrix
Biološki proces animal organ morphogenesis
growth plate cartilage development
skeletal system development
Ćelijska adhezija
extracellular matrix organization
negative regulation of apoptotic process
limb development
GO:0097285 apoptoza
ossification
chondrocyte development
endochondral bone growth
response to unfolded protein
Koagulacija (krv)
protein secretion
multicellular organism aging
Regulacija ekspresije gena
vascular associated smooth muscle contraction
protein processing
collagen fibril organization
bone mineralization
regulation of bone mineralization
BMP signaling pathway
multicellular organism growth
chondrocyte proliferation
tendon development
skin development
artery morphogenesis
musculoskeletal movement
neuromuscular process
cartilage development
bone morphogenesis
platelet aggregation
vascular associated smooth muscle cell development
bone growth
negative regulation of hemostasis
positive regulation of chondrocyte proliferation
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_000095

NM_016685

RefSeq (bjelančevina)

NP_000086

NP_057894

Lokacija (UCSC)Chr 19: 18.78 – 18.79 MbChr 8: 70.83 – 70.83 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Simboli
1020304050
MVPDTACVLLLTLAALGASGQGQSPLGSDLGPQMLRELQETNAALQDVRE
LLRQQVREITFLKNTVMECDACGMQQSVRTGLPSVRPLLHCAPGFCFPGV
ACIQTESGARCGPCPAGFTGNGSHCTDVNECNAHPCFPRVRCINTSPGFR
CEACPPGYSGPTHQGVGLAFAKANKQVCTDINECETGQHNCVPNSVCINT
RGSFQCGPCQPGFVGDQASGCQRRAQRFCPDGSPSECHEHADCVLERDGS
RSCVCAVGWAGNGILCGRDTDLDGFPDEKLRCPERQCRKDNCVTVPNSGQ
EDVDRDGIGDACDPDADGDGVPNEKDNCPLVRNPDQRNTDEDKWGDACDN
CRSQKNDDQKDTDQDGRGDACDDDIDGDRIRNQADNCPRVPNSDQKDSDG
DGIGDACDNCPQKSNPDQADVDHDFVGDACDSDQDQDGDGHQDSRDNCPT
VPNSAQEDSDHDGQGDACDDDDDNDGVPDSRDNCRLVPNPGQEDADRDGV
GDVCQDDFDADKVVDKIDVCPENAEVTLTDFRAFQTVVLDPEGDAQIDPN
WVVLNQGREIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFI
FGYQDSSSFYVVMWKQMEQTYWQANPFRAVAEPGIQLKAVKSSTGPGEQL
RNALWHTGDTESQVRLLWKDPRNVGWKDKKSYRWFLQHRPQVGYIRVRFY
EGPELVADSNVVLDTTMRGGRLGVFCFSQENIIWANLRYRCNDTIPEDYE
THQLRQA

Funkcija

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Protein koji je kodiran ovim genom je nekolageni vanćelijski matrikssni (ECM) protein.[8] Sastoji se od pet identičnih glikoproteinskih podjedinica, svaka sa EGF-om i domenima koji vežu kalcij (trombospondini). Oligomerizacija je rezultat stvaranja petolančanih upredenih zavojnica i disulfidnih veza. Čini se da vezanje za druge ECM proteine, poput kolagena, ovisi o dvovalentnim kationima. Mutacije mogu izazvati osteohondrodisplazije pseudoahondroplazije (PSACH) i multiplu epifiznu displaziju (MED).[7]

COMP je marker prometa hrskavice.[9] Jako je eksprimiran u fibroznim ožiljcima i sistemskoj sklerozi, a čini se da ima ulogu i u preuređivanju vaskularnog zida.[10]

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105664 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031849 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Newton G, Weremowicz S, Morton CC, Copeland NG, Gilbert DJ, Jenkins NA, Lawler J (Dec 1994). "Characterization of human and mouse cartilage oligomeric matrix protein". Genomics. 24 (3): 435–9. doi:10.1006/geno.1994.1649. PMID 7713493.
  6. ^ Briggs MD, Rasmussen IM, Weber JL, Yuen J, Reinker K, Garber AP, Rimoin DL, Cohn DH (Dec 1993). "Genetic linkage of mild pseudoachondroplasia (PSACH) to markers in the pericentromeric region of chromosome 19". Genomics. 18 (3): 656–60. doi:10.1016/S0888-7543(05)80369-6. PMID 8307576.
  7. ^ a b "Entrez Gene: COMP cartilage oligomeric matrix protein".
  8. ^ Paulsson M, Heinegård D (Aug 1981). "Purification and structural characterization of a cartilage matrix protein". The Biochemical Journal. 197 (2): 367–75. doi:10.1042/bj1970367. PMC 1163135. PMID 7325960.
  9. ^ Petersen SG, Saxne T, Heinegard D, Hansen M, Holm L, Koskinen S, Stordal C, Christensen H, Aagaard P, Kjaer M (Jan 2010). "Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training". Osteoarthritis and Cartilage. 18 (1): 34–40. doi:10.1016/j.joca.2009.07.004. PMID 19679221.
  10. ^ Halper J, Kjaer M (2014). "Basic components of connective tissues and extracellular matrix: elastin, fibrillin, fibulins, fibrinogen, fibronectin, laminin, tenascins and thrombospondins". Advances in Experimental Medicine and Biology. 802: 31–47. doi:10.1007/978-94-007-7893-1_3. ISBN 978-94-007-7892-4. PMID 24443019.

Dopunska literatura

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Vanjski linkovi

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