COMMD3-BMI1

COMMD3-BMI1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2H0D, 3RPG, 4R8P
Identifikatori
Aliasi	COMMD3-BMI1
Vanjski ID-jevi	MGI: 88174 HomoloGene: 3797 GeneCards: COMMD3-BMI1
Lokacija gena (čovjek)
Hrom.	Hromosom 10 (čovjek)
Kraj	22,329,542 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	18,691,440 bp
Ontologija gena
Molekularna funkcija	• promoter-specific chromatin binding; • RING-like zinc finger domain binding; • vezivanje iona metala; • GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje iona cinka;
Ćelijska komponenta	• citoplazma; • kompleks ubikvitin-ligaze; • nukleoplazma; • PRC1 complex; • PcG protein complex; • jedro; • citosol; • nuclear body;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated; • positive regulation of fibroblast proliferation; • GO:1901227 negative regulation of transcription by RNA polymerase II; • transcription, DNA-templated; • segment specification; • negative regulation of gene expression, epigenetic; • positive regulation of ubiquitin-protein transferase activity; • Regulacija ekspresije gena; • histone H2A-K119 monoubiquitination; • negative regulation of G0 to G1 transition; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization; • Hematopoeza;
	Izvori:Amigo / QuickGO
Ortolozi
	100532731
	12151
	ENSG00000269897
	ENSMUSG00000026739
	P35226
	P25916
	NM_001204062
	NM_007552
	NP_001190991; NP_005171
	NP_031578
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

COMMD3-BMI1 je gen koji kod ljudi kodira čitanje proteina COMMD3-BMI1.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 326 aminokiselina, а molekulska težina 36.949^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MHRTTRIKIT	ELNPHLMCVL	CGGYFIDATT	IIECLHSFCK	TCIVRYLETS
KYCPICDVQV	HKTRPLLNIR	SDKTLQDIVY	KLVPGLFKNE	MKRRRDFYAA
HPSADAANGS	NEDRGEVADE	DKRIITDDEI	ISLSIEFFDQ	NRLDRKVNKD
KEKSKEEVND	KRYLRCPAAM	TVMHLRKFLR	SKMDIPNTFQ	IDVMYEEEPL
KDYYTLMDIA	YIYTWRRNGP	LPLKYRVRPT	CKRMKISHQR	DGLTNAGELE
SDSGSDKANS	PAGGIPSTSS	CLPSPSTPVQ	SPHPQFPHIS	STMNGTSNSP
SGNHQSSFAN	RPRKSSVNGS	SATSSG

Funkcija

Ovaj lokus predstavlja prirodno čitanje transkripcija između susjednih COMM-domena koji sadrži protein 3 i kompleksa polinomnih proteina BMI-1 gena na hromosomu 10. Pročitani transkript proizvodi fuzijski protein koji dijeli identitet sekvence sa svakim pojedinačnim genskim proizvodom.^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000269897 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026739 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: COMMD3-BMI1 readthrough". Pristupljeno 5. 10. 2013.
^ "UniProt, P35226". Pristupljeno 31. 8. 2021.
^ prema RefSeq, februar 2011.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000269897 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026739 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: COMMD3-BMI1 readthrough". Pristupljeno 5. 10. 2013.

[UniProt-6] "UniProt, P35226". Pristupljeno 31. 8. 2021.

[7] rema RefSeq, februar 2011.

[5]

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