DHX58

Vjerovatna ATP-ovisna RNK-helikaza DDX23 je enzim koji je kod ljudi kodiran genom DDX23.

DHX58
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2RQA, 2W4R, 3EQT
Identifikatori
Aliasi	DHX58
Vanjski ID-jevi	OMIM: 608588 MGI: 1931560 HomoloGene: 69371 GeneCards: DHX58
Lokacija gena (čovjek) Hrom. Hromosom 17 (čovjek) Bend 17q21.2 Početak 42,101,404 bp Kraj 42,112,714 bp
Lokacija gena (miš) Hrom. Hromosom 11 (miš) Bend 11 D|11 63.52 cM Početak 100,585,710 bp Kraj 100,595,097 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • vezivanje sa DNK • nucleotide binding • GO:0008026 helicase activity • vezivanje iona cinka • vezivanje iona metala • GO:0001948, GO:0016582 vezivanje za proteine • single-stranded RNA binding • vezivanje sa RNK • double-stranded RNA binding • hydrolase activity • ATP binding Ćelijska komponenta • citoplazma Biološki proces • negative regulation of MDA-5 signaling pathway • regulation of innate immune response • immune system process • response to virus • positive regulation of RIG-I signaling pathway • defense response to virus • negative regulation of innate immune response • negative regulation of type I interferon production • Urođeni imunski sistem • GO:0022415 viral process • positive regulation of MDA-5 signaling pathway • positive regulation of type I interferon production • negative regulation of RIG-I signaling pathway • response to bacterium Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	79132	80861
Ensembl	ENSG00000108771	ENSMUSG00000017830
UniProt	Q96C10	Q99J87
RefSeq (mRNK)	NM_024119	NM_030150
RefSeq (bjelančevina)	NP_077024	NP_084426
Lokacija (UCSC)	Chr 17: 42.1 – 42.11 Mb	Chr 11: 100.59 – 100.6 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Ovaj gen kodira člana porodice proteina DEAD-boksa. Proteini iz te kutije, karakterizirani konzerviranim motivom Asp-Glu-Ala-Asp (DEAD), su pretpostavljene RNK-helikaze. Uključeni su u brojne ćelijske procese koji obuhvataju promjenu sekundarne strukture RNK, kao što je iniciranje translacije, jedarna i mitohondrijska prerada, te sastavljanje ribosoma i splajsosoma. Na osnovu njihovih obrazaca distribucije, vjeruje se da su neki članovi ove porodice uključeni u embriogenezu, spermatogenezu i ćelijski rast i diobu. Protein kodiran ovim genom je komponenta kompleksa U5 snRNP; može olakšati konformacijske promjene u splajsosomu tokom prerade jedarne pre-iRNK. Alternativno prerađena varijanta transkripta pronađena je za ovaj gen, ali njena biološka valjanost nije utvrđena.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 820 aminokiselina, a molekulska težina 95.583 Da.

10		20		30		40		50
MAGELADKKD		RDASPSKEER		KRSRTPDRER		DRDRDRKSSP		SKDRKRHRSR
DRRRGGSRSR		SRSRSKSAER		ERRHKERERD		KERDRNKKDR		DRDKDGHRRD
KDRKRSSLSP		GRGKDFKSRK		DRDSKKDEED		EHGDKKPKAQ		PLSLEELLAK
KKAEEEAEAK		PKFLSKAERE		AEALKRRQQE		VEERQRMLEE		ERKKRKQFQD
LGRKMLEDPQ		ERERRERRER		MERETNGNED		EEGRQKIREE		KDKSKELHAI
KERYLGGIKK		RRRTRHLNDR		KFVFEWDASE		DTSIDYNPLY		KERHQVQLLG
RGFIAGIDLK		QQKREQSRFY		GDLMEKRRTL		EEKEQEEARL		RKLRKKEAKQ
RWDDRHWSQK		KLDEMTDRDW		RIFREDYSIT		TKGGKIPNPI		RSWKDSSLPP
HILEVIDKCG		YKEPTPIQRQ		AIPIGLQNRD		IIGVAETGSG		KTAAFLIPLL
VWITTLPKID		RIEESDQGPY		AIILAPTREL		AQQIEEETIK		FGKPLGIRTV
AVIGGISRED		QGFRLRMGCE		IVIATPGRLI		DVLENRYLVL		SRCTYVVLDE
ADRMIDMGFE		PDVQKILEHM		PVSNQKPDTD		EAEDPEKMLA		NFESGKHKYR
QTVMFTATMP		PAVERLARSY		LRRPAVVYIG		SAGKPHERVE		QKVFLMSESE
KRKKLLAILE		QGFDPPIIIF		VNQKKGCDVL		AKSLEKMGYN		ACTLHGGKGQ
EQREFALSNL		KAGAKDILVA		TDVAGRGIDI		QDVSMVVNYD		MAKNIEDYIH
RIGRTGRAGK		SGVAITFLTK		EDSAVFYELK		QAILESPVSS		CPPELANHPD
AQHKPGTILT		KKRREETIFA

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Dopunska literatura

• Achsel T, Ahrens K, Brahms H, et al. (1998). "The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein". Mol. Cell. Biol. 18 (11): 6756–66. doi:10.1128/mcb.18.11.6756. PMC 109259. PMID 9774689.
• Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
• Irobi J, Nelis E, Verhoeven K, et al. (2002). "Mutation analysis of 12 candidate genes for distal hereditary motor neuropathy type II (distal HMN II) linked to 12q24.3". J. Peripher. Nerv. Syst. 7 (2): 87–95. doi:10.1046/j.1529-8027.2002.02014.x. PMID 12090300. S2CID 8453412.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.