CHD5
Hromodomensko-helikazno-DNK-vezujući protein 5 jest enzim koji je kod ljudi kodiran genom CHD5 sa hromosoma 1.[5][6][7]
Amiokiselininska sekvenca
urediDužina polipeptidnog lanca je 1.954 aminokiseline, a molekulska težina 223.050 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MRGPVGTEEE | LPRLFAEEME | NEDEMSEEED | GGLEAFDDFF | PVEPVSLPKK | ||||
| KKPKKLKENK | CKGKRKKKEG | SNDELSENEE | DLEEKSESEG | SDYSPNKKKK | ||||
| KKLKDKKEKK | AKRKKKDEDE | DDNDDGCLKE | PKSSGQLMAE | WGLDDVDYLF | ||||
| SEEDYHTLTN | YKAFSQFLRP | LIAKKNPKIP | MSKMMTVLGA | KWREFSANNP | ||||
| FKGSSAAAAA | AAVAAAVETV | TISPPLAVSP | PQVPQPVPIR | KAKTKEGKGP | ||||
| GVRKKIKGSK | DGKKKGKGKK | TAGLKFRFGG | ISNKRKKGSS | SEEDEREESD | ||||
| FDSASIHSAS | VRSECSAALG | KKSKRRRKKK | RIDDGDGYET | DHQDYCEVCQ | ||||
| QGGEIILCDT | CPRAYHLVCL | DPELEKAPEG | KWSCPHCEKE | GIQWEPKDDD | ||||
| DEEEEGGCEE | EEDDHMEFCR | VCKDGGELLC | CDACPSSYHL | HCLNPPLPEI | ||||
| PNGEWLCPRC | TCPPLKGKVQ | RILHWRWTEP | PAPFMVGLPG | PDVEPSLPPP | ||||
| KPLEGIPERE | FFVKWAGLSY | WHCSWVKELQ | LELYHTVMYR | NYQRKNDMDE | ||||
| PPPFDYGSGD | EDGKSEKRKN | KDPLYAKMEE | RFYRYGIKPE | WMMIHRILNH | ||||
| SFDKKGDVHY | LIKWKDLPYD | QCTWEIDDID | IPYYDNLKQA | YWGHRELMLG | ||||
| EDTRLPKRLL | KKGKKLRDDK | QEKPPDTPIV | DPTVKFDKQP | WYIDSTGGTL | ||||
| HPYQLEGLNW | LRFSWAQGTD | TILADEMGLG | KTVQTIVFLY | SLYKEGHSKG | ||||
| PYLVSAPLST | IINWEREFEM | WAPDFYVVTY | TGDKESRSVI | RENEFSFEDN | ||||
| AIRSGKKVFR | MKKEVQIKFH | VLLTSYELIT | IDQAILGSIE | WACLVVDEAH | ||||
| RLKNNQSKFF | RVLNSYKIDY | KLLLTGTPLQ | NNLEELFHLL | NFLTPERFNN | ||||
| LEGFLEEFAD | ISKEDQIKKL | HDLLGPHMLR | RLKADVFKNM | PAKTELIVRV | ||||
| ELSQMQKKYY | KFILTRNFEA | LNSKGGGNQV | SLLNIMMDLK | KCCNHPYLFP | ||||
| VAAVEAPVLP | NGSYDGSSLV | KSSGKLMLLQ | KMLKKLRDEG | HRVLIFSQMT | ||||
| KMLDLLEDFL | EYEGYKYERI | DGGITGGLRQ | EAIDRFNAPG | AQQFCFLLST | ||||
| RAGGLGINLA | TADTVIIYDS | DWNPHNDIQA | FSRAHRIGQN | KKVMIYRFVT | ||||
| RASVEERITQ | VAKRKMMLTH | LVVRPGLGSK | SGSMTKQELD | DILKFGTEEL | ||||
| FKDDVEGMMS | QGQRPVTPIP | DVQSSKGGNL | AASAKKKHGS | TPPGDNKDVE | ||||
| DSSVIHYDDA | AISKLLDRNQ | DATDDTELQN | MNEYLSSFKV | AQYVVREEDG | ||||
| VEEVEREIIK | QEENVDPDYW | EKLLRHHYEQ | QQEDLARNLG | KGKRIRKQVN | ||||
| YNDASQEDQE | WQDELSDNQS | EYSIGSEDED | EDFEERPEGQ | SGRRQSRRQL | ||||
| KSDRDKPLPP | LLARVGGNIE | VLGFNARQRK | AFLNAIMRWG | MPPQDAFNSH | ||||
| WLVRDLRGKS | EKEFRAYVSL | FMRHLCEPGA | DGAETFADGV | PREGLSRQHV | ||||
| LTRIGVMSLV | RKKVQEFEHV | NGKYSTPDLI | PEGPEGKKSG | EVISSDPNTP | ||||
| VPASPAHLLP | APLGLPDKME | AQLGYMDEKD | PGAQKPRQPL | EVQALPAALD | ||||
| RVESEDKHES | PASKERAREE | RPEETEKAPP | SPEQLPREEV | LPEKEKILDK | ||||
| LELSLIHSRG | DSSELRPDDT | KAEEKEPIET | QQNGDKEEDD | EGKKEDKKGK | ||||
| FKFMFNIADG | GFTELHTLWQ | NEERAAVSSG | KIYDIWHRRH | DYWLLAGIVT | ||||
| HGYARWQDIQ | NDPRYMILNE | PFKSEVHKGN | YLEMKNKFLA | RRFKLLEQAL | ||||
| VIEEQLRRAA | YLNMTQDPNH | PAMALNARLA | EVECLAESHQ | HLSKESLAGN | ||||
| KPANAVLHKV | LNQLEELLSD | MKADVTRLPS | MLSRIPPVAA | RLQMSERSIL | ||||
| SRLTNRAGDP | TIQQGAFGSS | QMYSNNFGPN | FRGPGPGGIV | NYNQMPLGPY | ||||
| VTDI |
Funkcija
urediOvaj enzim je dio potporodice hromodomenskog helikaznog DNK-vezujućeg (CHD) proteinskog kompleksa za remodeliranje hromatina zavisnih od ATP-a.
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000116254 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005045 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Schuster EF, Stoger R (Mar 2002). "CHD5 defines a new subfamily of chromodomain-SWI2/SNF2-like helicases". Mamm Genome. 13 (2): 117–9. doi:10.1007/s00335-001-3042-6. PMID 11889561. S2CID 1694959.
- ^ Thompson PM, Gotoh T, Kok M, White PS, Brodeur GM (Feb 2003). "CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system". Oncogene. 22 (7): 1002–11. doi:10.1038/sj.onc.1206211. PMID 12592387.
- ^ "Entrez Gene: CHD5 chromodomain helicase DNA binding protein 5".
- ^ "UniProt, Q8TDI0" (jezik: engleski). Pristupljeno 23. 11. 2021.
Dopunska literatura
uredi- Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
- Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
- Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Bagchi A, Papazoglu C, Wu Y, et al. (2007). "CHD5 is a tumor suppressor at human 1p36". Cell. 128 (3): 459–75. doi:10.1016/j.cell.2006.11.052. PMID 17289567. S2CID 13437928.
Vanjski linkovi
uredi- Lokacija ljudskog genoma CHD5 i stranica sa detaljima o genu CHD5 u UCSC Genome Browseru.