Hemokinski (C-C motivni) ligand 8 (CCL8), znan i kao monocitni hemoatraktantni protein 2 (MCP2), je protein koji je kod ljudi kodiran genom CCL8.[3][4]

CCL8
Dostupne strukture
PDBPretraga Human UniProta: PDBe RCSB
Spisak PDB ID kodova

1ESR

Identifikatori
AliasiCCL8
Vanjski ID-jeviOMIM: 602283 HomoloGene: 48362 GeneCards: CCL8
Lokacija gena (čovjek)
Hromosom 17 (čovjek)
Hrom.Hromosom 17 (čovjek)[1]
Hromosom 17 (čovjek)
Genomska lokacija za CCL8
Genomska lokacija za CCL8
Bend17q12Početak34,319,435 bp[1]
Kraj34,321,402 bp[1]
Ontologija gena
Molekularna funkcija protein kinase activity
cytokine activity
heparin binding
phospholipase activator activity
CCR chemokine receptor binding
chemokine activity
GO:0001948, GO:0016582 protein binding
CCR2 chemokine receptor binding
Ćelijska komponenta extracellular region
Vanćelijsko
Biološki proces G protein-coupled receptor signaling pathway
monocyte chemotaxis
chemokine-mediated signaling pathway
cellular response to tumor necrosis factor
cell-cell signaling
response to virus
cellular calcium ion homeostasis
neutrophil chemotaxis
Hemotaksija
GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity
cellular response to interleukin-1
GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor
positive regulation of ERK1 and ERK2 cascade
cellular response to interferon-gamma
lymphocyte chemotaxis
inflammatory response
calcium ion transport
GO:0072468 Transdukcija signala
Egzocitoza
protein phosphorylation
antimicrobial humoral immune response mediated by antimicrobial peptide
positive regulation of leukocyte migration
negative regulation of leukocyte proliferation
regulation of signaling receptor activity
Angiogeneza
eosinophil chemotaxis
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_005623

n/a

RefSeq (bjelančevina)

NP_005614

n/a

Lokacija (UCSC)Chr 17: 34.32 – 34.32 Mbn/a
PubMed pretraga[2]n/a
Wikipodaci
Pogledaj/uredi – čovjek

CCL8 je mali citokin koji pripada porodici CC hemokina. CCL8 protein se proizvodi kao prekursor koji sadrži 109 aminokiselina, a koji se cijepa da bi se dobio zreli CCL8 koji sadrži 75 aminokiselina. Kod ljudi, gen za CCL8 ima tri egzona i nalazi se unutar velikog skupa CC hemokinskih gena na hromosomu 17 q11.2.[4][5] MCP-2 je hemotaksijski i aktivira mnoge različite imunske ćelije, uključujući mastocite, eozinofile i bazofile (koje su uključene u alergijske reakcije) i monocite, T-ćelije i NK-ćelije koji su uključeni u upalni odgovor.[6][7] Svoje efekte CCL8 izaziva vezanjem na nekoliko različitih receptora na ćelijskoj površini, zvanih hemokinski receptori. Ovi receptori uključuju CCR1, CCR2B, CCR3 i CCR5.[7][8]

CCL8 je CC-hemokin koji koristi više ćelijskih receptora za privlačenje i aktiviranje ljudskih leukocita. CCL8 je snažni inhibitor HIV 1, zahvaljujući visokom afinitetu vezanja za receptor CCR5, jedan od glavnih koreceptora za HIV1.[9] Pored toga, CCL8 –u pripisuje se rast metastaza u ćelijama raka dojke. Manipulacija ovom hemokinskom aktivnošću utiče na histologiju tumora, promovirajući korake metastatskih procesa.[10] CCL8 je također uključen u privlačenje makrofaga u porođajnu deciduu.[11]

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 99 aminokiselina, a molekulska težina 11.246 Da.[12]

1020304050
MKVSAALLCLLLMAATFSPQGLAQPDSVSIPITCCFNVINRKIPIQRLES
YTRITNIQCPKEAVIFKTKRGKEVCADPKERWVRDSMKHLDQIFQNLKP
Simboli

Reference uredi

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108700 - Ensembl, maj 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Entrez Gene: chemokine (C-C motif) ligand 8".
  4. ^ a b Van Coillie E, Fiten P, Nomiyama H, Sakaki Y, Miura R, Yoshie O, Van Damme J, Opdenakker G (mart 1997). "The human MCP-2 gene (SCYA8): cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2". Genomics. 40 (2): 323–31. doi:10.1006/geno.1996.4594. PMID 9119400.
  5. ^ Van Damme J, Proost P, Lenaerts JP, Opdenakker G (juli 1992). "Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family". J. Exp. Med. 176 (1): 59–65. doi:10.1084/jem.176.1.59. PMC 2119277. PMID 1613466.
  6. ^ Proost P, Wuyts A, Van Damme J (januar 1996). "Human monocyte chemotactic proteins-2 and -3: structural and functional comparison with MCP-1". J. Leukoc. Biol. 59 (1): 67–74. doi:10.1002/jlb.59.1.67. PMID 8558070. S2CID 30445255.
  7. ^ a b Gong W, Howard OM, Turpin JA, Grimm MC, Ueda H, Gray PW, Raport CJ, Oppenheim JJ, Wang JM (februar 1998). "Monocyte chemotactic protein-2 activates CCR5 and blocks CD4/CCR5-mediated HIV-1 entry/replication". J. Biol. Chem. 273 (8): 4289–92. doi:10.1074/jbc.273.8.4289. PMID 9468473.
  8. ^ Ge B, Li J, Wei Z, Sun T, Song Y, Khan NU (2017). "Functional expression of CCL8 and its interaction with chemokine receptor CCR3". BMC Immunol. 18 (1): 54. doi:10.1186/s12865-017-0237-5. PMC 5745793. PMID 29281969.
  9. ^ PDB 1ESR; Blaszczyk J, Coillie EV, Proost P, Damme JV, Opdenakker G, Bujacz GD, Wang JM, Ji X (novembar 2000). "Complete crystal structure of monocyte chemotactic protein-2, a CC chemokine that interacts with multiple receptors". Biochemistry. 39 (46): 14075–81. doi:10.1021/bi0009340. PMID 11087354.
  10. ^ Farmaki E, Chatzistamou I, Kaza V, Kiaris H (2016). "A CCL8 gradient drives breast cancer cell dissemination". Oncogene. 35 (49): 6309–6318. doi:10.1038/onc.2016.161. PMC 5112152. PMID 27181207.
  11. ^ Hamilton SA, Tower CL, Jones RL (2013). "Identification of chemokines associated with the recruitment of decidual leukocytes in human labour: potential novel targets for preterm labour". PLOS ONE. 8 (2): e56946. doi:10.1371/journal.pone.0056946. PMC 3579936. PMID 23451115.
  12. ^ "UniProt, P80075". Pristupljeno 27. 6. 2021.

Vanjski linkovi uredi

Dopunska literatura uredi