CCL14

Pretraga za
Strukture	Swiss-model
Domene	InterPro

Hemokinski (C-C motivni) ligand 14
Hemokinski (C-C motivni) ligand 14
Identifikatori
Simbol	CCL14
Alt. simboli	SCYA14, HCC-1, HCC-3, NCC-2, SCYL2, CKb1, MCIF
NCBI gen	6358
HGNC	10612
OMIM	601392
RefSeq	NM_032962
UniProt	Q16627
Ostali podaci
Lokus	Hrom. 17 q11.2
Strukture
Pretraga za
Strukture	Swiss-model
Domene	InterPro

CCL14
Dostupne strukture
PDB	Pretraga Human UniProta: PDBe RCSB
Spisak PDB ID kodova
	2Q8R, 2Q8T
Identifikatori
Aliasi	CCL14
Vanjski ID-jevi	OMIM: 601392 HomoloGene: 57197 GeneCards: CCL14
Lokacija gena (čovjek)
Hrom.	Hromosom 17 (čovjek)
Kraj	35,987,004 bp
Ontologija gena
Molekularna funkcija	• chemokine activity; • cytokine activity; • CCR chemokine receptor binding;
Ćelijska komponenta	• extracellular region; • Vanćelijsko;
Biološki proces	• chemokine-mediated signaling pathway; • lymphocyte chemotaxis; • cellular response to tumor necrosis factor; • G protein-coupled receptor signaling pathway; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • inflammatory response; • cellular calcium ion homeostasis; • cellular response to interleukin-1; • monocyte chemotaxis; • neutrophil chemotaxis; • positive regulation of cell population proliferation; • positive regulation of ERK1 and ERK2 cascade; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor; • cellular response to interferon-gamma; • regulation of signaling receptor activity; • positive regulation of inflammatory response;
	Izvori:Amigo / QuickGO
Ortolozi
	6358
	n/a
	ENSG00000277236; ENSG00000276409
	n/a
	Q16627
	n/a
	NM_032963; NM_004166; NM_032962
	n/a
	NP_116738; NP_116739
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Hemokinski (C-C motivni) ligand 14 (CCL14) jest mali citokin koji pripada porodici CC hemokini. Također je poznat kao HCC-1. Proizvodi se kao proteinski prekursor koji se prerađuje da bi se stvorio zreli aktivni protein, koji sadrži 74 aminokiseline i koji je po aminokiselinskom sastavu identičan sa CCL3 i CCL4. Ovaj hemokin se eksprimira u različitim tkivima, uključujući slezenu, koštanu srž, jetru, mišiće i crijeva.^[3] CCL14 aktivira monocite, ali ne inducira njihove hemotaksije. Ljudski CCL14 nalazi se na hromosomu 17 unutar skupa drugih hemokina koji pripadaju porodici CC.^[4]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 93 aminokiseline, a molekulska težina 678 Da.^[5]

10		20		30		40		50
MKISVAAIPF		FLLITIALGT		KTESSSRGPY		HPSECCFTYT		TYKIPRQRIM
DYYETNSQCS		KPGIVFITKR		GHSVCTNPSD		KWVQDYIKDM		KEN

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference

^ ^a ^b ^c ENSG00000276409 GRCh38: Ensembl release 89: ENSG00000277236, ENSG00000276409 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schulz-Knappe et al., HCC-1, a novel chemokine from human plasma. J. Exp. Med., 1996, 183: 295-299.
^ Naruseet al., A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics, 1996, 34: 236-240.
^ "UniProt, Q16627". Pristupljeno 28. 6. 2021.

[refGRCh38Ensembl-1] ENSG00000276409 GRCh38: Ensembl release 89: ENSG00000277236, ENSG00000276409 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] Schulz-Knappe et al., HCC-1, a novel chemokine from human plasma. J. Exp. Med., 1996, 183: 295-299.

[4] Naruseet al., A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics, 1996, 34: 236-240.

[UniProt-5] "UniProt, Q16627". Pristupljeno 28. 6. 2021.

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