Kaplain-5

Kaplain-5
Identifikatori
Aliasi	CAPN5
Vanjski ID-jevi	OMIM: 602537 MGI: 1100859 HomoloGene: 31212 GeneCards: CAPN5
Lokacija gena (čovjek)
Hrom.	Hromosom 11 (čovjek)
Kraj	77,126,155 bp
Lokacija gena (miš)
Hrom.	Hromosom 7 (miš)
Kraj	98,178,274 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0070122 peptidase activity; • cysteine-type peptidase activity; • hydrolase activity; • calcium-dependent cysteine-type endopeptidase activity;
Ćelijska komponenta	• cell surface; • Egzosom; • intracellular anatomical structure; • focal adhesion; • citoplazma;
Biološki proces	• GO:0072468 Transdukcija signala; • Proteoliza;
	Izvori:Amigo / QuickGO
Ortolozi
	726
	12337
	ENSG00000149260
	ENSMUSG00000035547
	O15484
	O08688
	NM_004055
	NM_001301250; NM_007602
	NP_004046
	NP_001288179; NP_031628
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Kalpain-5 jest protein koji je kod ljudi kodiran genom CAPN5 sa hromosoma 11.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 640 aminokiselina, a molekulska težina 73.169 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MFSCVKPYED	QNYSALRRDC	RRRKVLFEDP	LFPATDDSLY	YKGTPGPAVR
WKRPKGICED	PRLFVDGISS	HDLHQGQVGN	CWFVAACSSL	ASRESLWQKV
IPDWKEQEWD	PEKPNAYAGI	FHFHFWRFGE	WVDVVIDDRL	PTVNNQLIYC
HSNSRNEFWC	ALVEKAYAKL	AGCYQALDGG	NTADALVDFT	GGVSEPIDLT
EGDFANDETK	RNQLFERMLK	VHSRGGLISA	SIKAVTAADM	EARLACGLVK
GHAYAVTDVR	KVRLGHGLLA	FFKSEKLDMI	RLRNPWGERE	WNGPWSDTSE
EWQKVSKSER	EKMGVTVQDD	GEFWMTFEDV	CRYFTDIIKC	RVINTSHLSI
HKTWEEARLH	GAWTLHEDPR	QNRGGGCINH	KDTFFQNPQY	IFEVKKPEDE
VLICIQQRPK	RSTRREGKGE	NLAIGFDIYK	VEENRQYRMH	SLQHKAASSI
YINSRSVFLR	TDQPEGRYVI	IPTTFEPGHT	GEFLLRVFTD	VPSNCRELRL
DEPPHTCWSS	LCGYPQLVTQ	VHVLGAAGLK	DSPTGANSYV	IIKCEGDKVR
SAVQKGTSTP	EYNVKGIFYR	KKLSQPITVQ	VWNHRVLKDE	FLGQVHLKAD
PDNLQALHTL	HLRDRNSRQP	SNLPGTVAVH	ILSSTSLMAV

Funkcija

Kalpaini su cisteinske proteaze zavisne od kalcija ,uključene u transdukciju signala u različitim ćelijskim procesima. Funkcionalni protein kalpaina sastoji se od nepromjenjive male podjedinice i 1 iz porodice velikih podjedinica. CAPN5 je jedna od velikih podjedinica. Za razliku od nekih kalpaina, CAPN5 i CAPN6 nemaju domen IV sličan kalmodulinu. Zbog značajne sličnosti sa genom za određivanje spola tra-3 kod Caenorhabditis elegans, CAPN5 se naziva i HTRA3.^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000149260 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035547 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Matena K, Boehm T, Dear N (Apr 1998). "Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily". Genomics. 48 (1): 117–20. doi:10.1006/geno.1997.5133. PMID 9503024.
^ Mugita N, Kimura Y, Ogawa M, Saya H, Nakao M (Dec 1997). "Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene". Biochem Biophys Res Commun. 239 (3): 845–50. doi:10.1006/bbrc.1997.7571. PMID 9367857.
^ ^a ^b ^c "Entrez Gene: CAPN5 calpain 5".

Dopunaka literatura

Vanderklish PW, Bahr BA (2001). "The pathogenic activation of calpain: a marker and mediator of cellular toxicity and disease states". International Journal of Experimental Pathology. 81 (5): 323–39. doi:10.1111/j.1365-2613.2000.00169.x. PMC 2517738. PMID 11168679.
Sato K, Kawashima S (2002). "Calpain function in the modulation of signal transduction molecules". Biol. Chem. 382 (5): 743–51. doi:10.1515/BC.2001.090. PMID 11517927. S2CID 882390.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Dear N, Matena K, Vingron M, Boehm T (1997). "A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution". Genomics. 45 (1): 175–84. doi:10.1006/geno.1997.4870. PMID 9339374.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Waghray A, Wang DS, McKinsey D, et al. (2004). "Molecular cloning and characterization of rat and human calpain-5". Biochem. Biophys. Res. Commun. 324 (1): 46–51. doi:10.1016/j.bbrc.2004.09.012. PMID 15464980.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
González A, Sáez ME, Aragón MJ, et al. (2006). "Specific haplotypes of the CALPAIN-5 gene are associated with polycystic ovary syndrome". Hum. Reprod. 21 (4): 943–51. doi:10.1093/humrep/dei443. PMID 16396936.
Sáez ME, Martínez-Larrad MT, Ramírez-Lorca R, et al. (2007). "Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels". BMC Med. Genet. 8: 1. doi:10.1186/1471-2350-8-1. PMC 1783645. PMID 17227582.

Vanjski linkovi

The MEROPS online database for peptidases and their inhibitors: C02.011 Arhivirano 8. 3. 2005. na Wayback Machine
Lokacija ljudskog genoma CAPN5 i stranica sa detaljima o genu CAPN5 u UCSC Genome Browseru.
Lokacija ljudskog genoma HTRA3 i stranica sa detaljima o genu HTRA3 u UCSC Genome Browseru.

Šablon:Cjsteinske proteaze

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000149260 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035547 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9503024-5] Matena K, Boehm T, Dear N (Apr 1998). "Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily". Genomics. 48 (1): 117–20. doi:10.1006/geno.1997.5133. PMID 9503024.

[pmid9367857-6] Mugita N, Kimura Y, Ogawa M, Saya H, Nakao M (Dec 1997). "Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene". Biochem Biophys Res Commun. 239 (3): 845–50. doi:10.1006/bbrc.1997.7571. PMID 9367857.

[entrez-7] "Entrez Gene: CAPN5 calpain 5".

[5]

[6]

[7]

[1]

[2]

[3]

[4]