CAPG

CAPG
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1J72, 1JHW
Identifikatori
Aliasi	CAPG
Vanjski ID-jevi	OMIM: 153615 MGI: 1098259 HomoloGene: 37523 GeneCards: CAPG
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	85,418,432 bp
Lokacija gena (miš)
Hrom.	Hromosom 6 (miš)
Kraj	72,539,966 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0032403 protein-containing complex binding; • actin binding; • GO:0001948, GO:0016582 vezivanje za proteine; • protein domain specific binding; • cadherin binding; • actin filament binding;
Ćelijska komponenta	• citoplazma; • F-actin capping protein complex; • Melanosom; • Centriole; • mitotic spindle; • Jedarce; • Egzosom; • jedro; • Flemming body; • nukleoplazma; • extracellular region; • ruffle; • lamellipodium; • projekcija ćelije;
Biološki proces	• barbed-end actin filament capping; • extracellular matrix disassembly; • positive regulation of podosome assembly; • actin filament capping; • GO:0034622 protein-containing complex assembly;
	Izvori:Amigo / QuickGO
Ortolozi
	822
	12332
	ENSG00000042493
	ENSMUSG00000056737
	P40121
	P24452
NM_001256139; NM_001256140; NM_001747; NM_001320732; NM_001320733;
	NM_001320734
	NM_001042534; NM_001271395; NM_001271415; NM_007599
NP_001243068; NP_001243069; NP_001307661; NP_001307662; NP_001307663;
	NP_001738
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Proteinski zatvarač makrofaga (CAPG), znan i kao aktinski regulatorni protein CAP-G, jest protein koji je kod ljudi kodiran genom CAPG sa hromosoma 2.^[5]^[6]^[7]

Amiokiselininska sekvenca uredi

Dužina polipeptidnog lanca je 348 aminokiselina, a molkekulska iežina 38.499 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MYTAIPQSGS	PFPGSVQDPG	LHVWRVEKLK	PVPVAQENQG	VFFSGDSYLV
LHNGPEEVSH	LHLWIGQQSS	RDEQGACAVL	AVHLNTLLGE	RPVQHREVQG
NESDLFMSYF	PRGLKYQEGG	VESAFHKTST	GAPAAIKKLY	QVKGKKNIRA
TERALNWDSF	NTGDCFILDL	GQNIFAWCGG	KSNILERNKA	RDLALAIRDS
ERQGKAQVEI	VTDGEEPAEM	IQVLGPKPAL	KEGNPEEDLT	ADKANAQAAA
LYKVSDATGQ	MNLTKVADSS	PFALELLISD	DCFVLDNGLC	GKIYIWKGRK
ANEKERQAAL	QVAEGFISRM	QYAPNTQVEI	LPQGHESPIF	KQFFKDWK

Funkcija uredi

Ovaj gen kodira člana gelsolin/vilin porodice aktin-regulatornih proteina.^[9] Kodirani protein reverzibilno blokira bodljikave krajeve F-aktinskih filamenata na Ca2+ski i fosfoinozitidno-regulisan način, ali ne prekida prethodno formirane aktinske filamente. Pokrivanjem bodljikavih krajeva aktinskih filamenata, kodirani protein doprinosi kontroli pokretljivosti zasnovanoj na aktinu u nemišićnim ćelijama. Uočene su alternativno prerađene varijanta transkripta, ali nisu u potpunosti opisane.^[7]

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000042493 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056737 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dabiri GA, Young CL, Rosenbloom J, Southwick FS (Sep 1992). "Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages". J Biol Chem. 267 (23): 16545–52. doi:10.1016/S0021-9258(18)42037-6. PMID 1322908.
^ Pellieux C, Desgeorges A, Pigeon CH, Chambaz C, Yin H, Hayoz D, Silacci P (Jul 2003). "Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress". J Biol Chem. 278 (31): 29136–44. doi:10.1074/jbc.M300598200. PMID 12754261.
^ ^a ^b "Entrez Gene: CAPG capping protein (actin filament), gelsolin-like".
^ "UniProt, P40121" (jezik: engleski). Pristupljeno 11. 11. 2021.
^ Ghoshdastider, U; Popp, D; Burtnick, L. D.; Robinson, R. C. (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256. S2CID 205643538.

Dopunska literatura uredi

Southwick FS (1995). "Gain-of-function mutations conferring actin-severing activity to human macrophage cap G". J. Biol. Chem. 270 (1): 45–8. doi:10.1074/jbc.270.1.45. PMID 7814409.
Mishra VS, Henske EP, Kwiatkowski DJ, Southwick FS (1995). "The human actin-regulatory protein cap G: gene structure and chromosome location". Genomics. 23 (3): 560–5. doi:10.1006/geno.1994.1543. PMID 7851883.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Hirano T, Kobayashi R, Hirano M (1997). "Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein". Cell. 89 (4): 511–21. doi:10.1016/S0092-8674(00)80233-0. PMID 9160743. S2CID 15061740.
Cabello OA, Eliseeva E, He WG, et al. (2002). "Cell cycle-dependent expression and nucleolar localization of hCAP-H". Mol. Biol. Cell. 12 (11): 3527–37. doi:10.1091/mbc.12.11.3527. PMC 60273. PMID 11694586.
Van Impe K, De Corte V, Eichinger L, et al. (2003). "The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins". J. Biol. Chem. 278 (20): 17945–52. doi:10.1074/jbc.M209946200. PMID 12637565.
De Corte V, Van Impe K, Bruyneel E, et al. (2005). "Increased importin-beta-dependent nuclear import of the actin modulating protein CapG promotes cell invasion". J. Cell Sci. 117 (Pt 22): 5283–92. doi:10.1242/jcs.01410. PMID 15454578.
Watari A, Takaki K, Higashiyama S, et al. (2007). "Suppression of tumorigenicity, but not anchorage independence, of human cancer cells by new candidate tumor suppressor gene CapG". Oncogene. 25 (56): 7373–80. doi:10.1038/sj.onc.1209732. PMID 16767159.
Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.

Vanjski linkovi uredi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000042493 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000056737 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1322908-5] Dabiri GA, Young CL, Rosenbloom J, Southwick FS (Sep 1992). "Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages". J Biol Chem. 267 (23): 16545–52. doi:10.1016/S0021-9258(18)42037-6. PMID 1322908.

[pmid12754261-6] Pellieux C, Desgeorges A, Pigeon CH, Chambaz C, Yin H, Hayoz D, Silacci P (Jul 2003). "Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress". J Biol Chem. 278 (31): 29136–44. doi:10.1074/jbc.M300598200. PMID 12754261.

[entrez-7] "Entrez Gene: CAPG capping protein (actin filament), gelsolin-like".

[UniProt-8] "UniProt, P40121" (jezik: engleski). Pristupljeno 11. 11. 2021.

[9] Ghoshdastider, U; Popp, D; Burtnick, L. D.; Robinson, R. C. (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256. S2CID 205643538.

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