Kalcij/kalmodulin-ovisna protein-kinaza ID je protein koji je kod ljudi kodirangenom CAMK1D na hromosomu 10 (lokus 10p13).[5]

CAMK1D
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

2JC6

Identifikatori
AliasiCAMK1D
Vanjski ID-jeviOMIM: 607957 MGI: 2442190 HomoloGene: 121858 GeneCards: CAMK1D
Lokacija gena (čovjek)
Hromosom 10 (čovjek)
Hrom.Hromosom 10 (čovjek)[1]
Hromosom 10 (čovjek)
Genomska lokacija za CAMK1D
Genomska lokacija za CAMK1D
Bend10p13Početak12,349,547 bp[1]
Kraj12,835,545 bp[1]
Lokacija gena (miš)
Hromosom 2 (miš)
Hrom.Hromosom 2 (miš)[2]
Hromosom 2 (miš)
Genomska lokacija za CAMK1D
Genomska lokacija za CAMK1D
Bend2|2 A1Početak5,298,268 bp[2]
Kraj5,719,326 bp[2]
Ontologija gena
Molekularna funkcija aktivnost sa transferazom
nucleotide binding
protein kinase activity
kinase activity
protein serine/threonine kinase activity
catalytic activity
ATP binding
calmodulin-dependent protein kinase activity
calmodulin binding
Ćelijska komponenta jedro
citoplazma
Biološki proces regulation of granulocyte chemotaxis
positive regulation of phagocytosis
Fosforilacija
negative regulation of apoptotic process
regulation of dendrite development
nervous system development
protein phosphorylation
positive regulation of CREB transcription factor activity
positive regulation of apoptotic process
metabolizam
inflammatory response
positive regulation of respiratory burst
positive regulation of neutrophil chemotaxis
positive regulation of neuron projection development
GO:0035404 peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
GO:0007243 intracellular signal transduction
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_020397
NM_153498
NM_001351032

NM_001290374
NM_001290375
NM_001290376
NM_177343

RefSeq (bjelančevina)

NP_065130
NP_705718
NP_001337961

NP_001277303
NP_001277304
NP_001277305
NP_796317

Lokacija (UCSC)Chr 10: 12.35 – 12.84 MbChr 2: 5.3 – 5.72 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca iznosi 385 aminokiselina, a molekularna masa 42.914.[6]

1020304050
MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFA
VKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQL
VSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENL
LYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSK
AVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISD
SAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN
FAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLAP
STLCSFISSSSGVSGVGAERRPRPTTVTAVHSGSK

Funkcija

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Ovaj gen kodira člana Ca2+/kalmodulin ovisne protein-kinaze 1 potporodice serin/treonin kinaza. Kodirani protein može biti uključen u regulaciju funkcije granulocita putem transdukcije signala hemokina. Opisane su alternativno prerađene varijante transkripta koje kodiraju različite izoforme ovog gena.

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183049 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039145 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Calcium/calmodulin-dependent protein kinase ID".
  6. ^ "UniProt, Q8IU85". Pristupljeno 30. 8. 2021.

Vanjski linkovi

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