C16orf84

CTU2, nekada bio poznat kao C16orf84, jest ljudski gen na hromosomu 16. iRNK kodira dužu izoformu. Gen kodira citoplazmatski protein koji vjerojatno ima ulogu u modifikaciji tRNK.

C16orf84
Identifikatori
Aliasi	CTU2
Vanjski ID-jevi	OMIM: 617057 MGI: 1914215 HomoloGene: 79815 GeneCards: CTU2
Lokacija gena (čovjek) Hrom. Hromosom 16 (čovjek) Bend 16q24.3 Početak 88,706,483 bp Kraj 88,715,396 bp
Lokacija gena (miš) Hrom. Hromosom 8 (miš) Bend 8|8 E1 Početak 123,202,882 bp Kraj 123,210,877 bp
Ontologija gena Molekularna funkcija • tRNA binding • GO:0001948, GO:0016582 vezivanje za proteine • sulfurtransferase activity • nucleotidyltransferase activity Ćelijska komponenta • citoplazma • citosol • GO:0009327 makromolekulani kompleks Biološki proces • tRNA wobble uridine modification • tRNA thio-modification • tRNA processing • tRNA wobble position uridine thiolation • protein urmylation • tRNA modification Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	348180	66965
Ensembl	ENSG00000174177	ENSMUSG00000049482
UniProt	Q2VPK5	Q3U308
RefSeq (mRNK)	NM_001012759 NM_001012762 NM_001318507 NM_001318513	NM_153775
RefSeq (bjelančevina)	NP_001012777 NP_001012780 NP_001305436 NP_001305442	NP_722470
Lokacija (UCSC)	Chr 16: 88.71 – 88.72 Mb	Chr 8: 123.2 – 123.21 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 515 aminokiselina, a molekulska težina 56.107 Da.

10		20		30		40		50
MCQVGEDYGE		PAPEEPPPAP		RPSREQKCVK		CKEAQPVVVI		RAGDAFCRDC
FKAFYVHKFR		AMLGKNRLIF		PGEKVLLAWS		GGPSSSSMVW		QVLEGLSQDS
AKRLRFVAGV		IFVDEGAACG		QSLEERSKTL		AEVKPILQAT		GFPWHVVALE
EVFSLPPSVL		WCSAQELVGS		EGAYKAAVDS		FLQQQHVLGA		GGGPGPTQGE
EQPPQPPLDP		QNLARPPAPA		QTEALSQLFC		SVRTLTAKEE		LLQTLRTHLI
LHMARAHGYS		KVMTGDSCTR		LAIKLMTNLA		LGRGAFLAWD		TGFSDERHGD
VVVVRPMRDH		TLKEVAFYNR		LFSVPSVFTP		AVDTKAPEKA		SIHRLMEAFI
LRLQTQFPST		VSTVYRTSEK		LVKGPRDGPA		AGDSGPRCLL		CMCALDVDAA
DSATAFGAQT		SSRLSQMQSP		IPLTETRTPP		GPCCSPGVGW		AQRCGQGACR
REDPQACIEE		QLCYSCRVNM		KDLPSLDPLP		PYILAEAQLR		TQRAWGLQEI
RDCLIEDSDD		EAGQS

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Dopunska literatura

• Schlieker CD, Van der Veen AG, Damon JR, Spooner E, Ploegh HL (novembar 2008). "A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway". Proc. Natl. Acad. Sci. U.S.A. 105 (47): 18255–60. Bibcode:2008PNAS..10518255S. doi:10.1073/pnas.0808756105. PMC 2584574. PMID 19017811.
• Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP (august 2008). "A quantitative atlas of mitotic phosphorylation". Proc. Natl. Acad. Sci. U.S.A. 105 (31): 10762–7. Bibcode:2008PNAS..10510762D. doi:10.1073/pnas.0805139105. PMC 2504835. PMID 18669648.

Vanjski linkovi

• Lokacija ljudskog genoma CTU2 i stranica sa detaljima o genu CTU2 u UCSC Genome Browseru.