BNC2
Protein cinovog prsta bazonuklin-2 je protein koji je kod ljudi kodiran genom BNC2.[5][6] Nedavno se pokazalo da BCN2 utpče na razinu pigmentacije kože u Evropljana.[7] Genomska regija koja obuhvata gen BCN2 ima 60% DNK sekvence neandertalaca.[8]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 1.099 aminokiselina, а molekulska težina 122.330 Da.[9]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAHLGPTPPP | HSLNYKSEDR | LSEQDWPAYF | KVPCCGVDTS | QIESEEAEVD | ||||
| VRERETQRDR | EPKRARDLTL | RDSCTDNSMQ | FGTRTTTAEP | GFMGTWQNAD | ||||
| TNLLFRMSQQ | AIRCTLVNCT | CECFQPGKIN | LRTCDQCKHG | WVAHALDKLS | ||||
| TQHLYHPTQV | EIVQSNVVFD | ISSLMLYGTQ | AVPVRLKILL | DRLFSVLKQE | ||||
| EVLHILHGLG | WTLRDYVRGY | ILQDAAGKVL | DRWAIMSREE | EIITLQQFLR | ||||
| FGETKSIVEL | MAIQEKEGQA | VAVPSSKTDS | DIRTFIESNN | RTRSPSLLAH | ||||
| LENSNPSSIH | HFENIPNSLA | FLLPFQYINP | VSAPLLGLPP | NGLLLEQPGL | ||||
| RLREPSLSTQ | NEYNESSESE | VSPTPYKNDQ | TPNRNALTSI | TNVEPKTEPA | ||||
| CVSPIQNSAP | VSDLTKTEHP | KSSFRIHRMR | RMGSASRKGR | VFCNACGKTF | ||||
| YDKGTLKIHY | NAVHLKIKHR | CTIEGCNMVF | SSLRSRNRHS | ANPNPRLHMP | ||||
| MLRNNRDKDL | IRATSGAATP | VIASTKSNLA | LTSPGRPPMG | FTTPPLDPVL | ||||
| QNPLPSQLVF | SGLKTVQPVP | PFYRSLLTPG | EMVSPPTSLP | TSPIIPTSGT | ||||
| IEQHPPPPSE | PVVPAVMMAT | HEPSADLAPK | KKPRKSSMPV | KIEKEIIDTA | ||||
| DEFDDEDDDP | NDGGAVVNDM | SHDNHCHSQE | EMSPGMSVKD | FSKHNRTRCI | ||||
| SRTEIRRADS | MTSEDQEPER | DYENESESSE | PKLGEESMEG | DEHIHSEVSE | ||||
| KVLMNSERPD | ENHSEPSHQD | VIKVKEEFTD | PTYDMFYMSQ | YGLYNGGGAS | ||||
| MAALHESFTS | SLNYGSPQKF | SPEGDLCSSP | DPKICYVCKK | SFKSSYSVKL | ||||
| HYRNVHLKEM | HVCTVAGCNA | AFPSRRSRDR | HSANINLHRK | LLTKELDDMG | ||||
| LDSSQPSLSK | DLRDEFLVKI | YGAQHPMGLD | VREDASSPAG | TEDSHLNGYG | ||||
| RGMAEDYMVL | DLSTTSSLQS | SSSIHSSRES | DAGSDEGILL | DDIDGASDSG | ||||
| ESAHKAEAPA | LPGSLGAEVS | GSLMFSSLSG | SNGGIMCNIC | HKMYSNKGTL | ||||
| RVHYKTVHLR | EMHKCKVPGC | NMMFSSVRSR | NRHSQNPNLH | KNIPFTSVD |
Također pogledajte
urediReference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000173068 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028487 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (Jan 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- ^ "Entrez Gene: BNC2 basonuclin 2".
- ^ Jacobs LC, Wollstein A, Lao O, Hofman A, Klaver CC, Uitterlinden AG, Nijsten T, Kayser M, Liu F (Feb 2013). "Comprehensive candidate gene study highlights UGT1A and BNC2 as new genes determining continuous skin color variation in Europeans". Human Genetics. 132 (2): 147–58. doi:10.1007/s00439-012-1232-9. PMID 23052946. S2CID 6057298.
- ^ Vattathil S, Akey JM (Oct 2015). "Small Amounts of Archaic Admixture Provide Big Insights into Human History". Cell. 163 (2): 281–4. doi:10.1016/j.cell.2015.09.042. PMID 26451479.
- ^ "UniProt, Q6ZN30". Pristupljeno 6. 9. 2021.
Dopunska literatura
uredi- Vanhoutteghem A, Djian P (Jan 2007). "The human basonuclin 2 gene has the potential to generate nearly 90,000 mRNA isoforms encoding over 2000 different proteins". Genomics. 89 (1): 44–58. doi:10.1016/j.ygeno.2006.07.006. PMID 16942855.
- Vanhoutteghem A, Djian P (Aug 2006). "Basonuclins 1 and 2, whose genes share a common origin, are proteins with widely different properties and functions". Proceedings of the National Academy of Sciences of the United States of America. 103 (33): 12423–8. Bibcode:2006PNAS..10312423V. doi:10.1073/pnas.0605086103. PMC 1567895. PMID 16891417.
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Benevolenskaya EV, Murray HL, Branton P, Young RA, Kaelin WG (Jun 2005). "Binding of pRB to the PHD protein RBP2 promotes cellular differentiation". Molecular Cell. 18 (6): 623–35. doi:10.1016/j.molcel.2005.05.012. PMID 15949438.
- Romano RA, Li H, Tummala R, Maul R, Sinha S (maj 2004). "Identification of Basonuclin2, a DNA-binding zinc-finger protein expressed in germ tissues and skin keratinocytes". Genomics. 83 (5): 821–33. doi:10.1016/j.ygeno.2003.11.009. PMID 15081112.
- Vanhoutteghem A, Djian P (Mar 2004). "Basonuclin 2: an extremely conserved homolog of the zinc finger protein basonuclin". Proceedings of the National Academy of Sciences of the United States of America. 101 (10): 3468–73. Bibcode:2004PNAS..101.3468V. doi:10.1073/pnas.0400268101. PMC 373485. PMID 14988505.