Koštanomorfogenetski protein 5

Koštanomorfogenetski protein 5
Identifikatori
Aliasi	BMP5
Vanjski ID-jevi	OMIM: 112265 MGI: 88181 HomoloGene: 22412 GeneCards: BMP5
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	55,875,590 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	75,807,592 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• cytokine activity; • BMP receptor binding; • transforming growth factor beta receptor binding; • growth factor activity;
Ćelijska komponenta	• extracellular region; • Vanćelijsko; • Vezikula; • ćelijska komponenta;
Biološki proces	• regulation of apoptotic process; • pattern specification process; • skeletal system development; • Ćelijska diferencijacija; • male genitalia development; • regulation of MAPK cascade; • SMAD protein signal transduction; • ossification; • positive regulation of epithelial cell proliferation; • negative regulation of mononuclear cell migration; • negative regulation of cortisol biosynthetic process; • positive regulation of pathway-restricted SMAD protein phosphorylation; • positive regulation of dendrite development; • BMP signaling pathway; • multicellular organism development; • cartilage development; • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; • negative regulation of insulin-like growth factor receptor signaling pathway; • type B pancreatic cell development; • negative regulation of steroid biosynthetic process; • negative regulation of epithelial to mesenchymal transition; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • negative regulation of cell population proliferation; • negative regulation of aldosterone biosynthetic process; • endocardial cushion formation; • pericardium morphogenesis; • neural fold elevation formation; • hindbrain development; • cardiac muscle tissue development; • pharyngeal system development; • cardiac septum morphogenesis; • chorio-allantoic fusion; • heart trabecula morphogenesis; • allantois development; • regulation of signaling receptor activity; • ear development; • anterior head development; • positive regulation of cell population proliferation; • cell development; • GO:0072468 Transdukcija signala;
	Izvori:Amigo / QuickGO
Ortolozi
	653
	12160
	ENSG00000112175
	ENSMUSG00000032179
	P22003
	P49003
	NM_021073; NM_001329754; NM_001329756
	NM_007555
	NP_001316683; NP_001316685; NP_066551; NP_066551.1
	NP_031581
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Koštanomorfogenetski protein 5 jest protein koji je kod ljudi kodiran genom BMP5 sa hromosoma 6.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 454 aminokiseline, a molekulska težina 51.737 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MHLTVFLLKG	IVGFLWSCWV	LVGYAKGGLG	DNHVHSSFIY	RRLRNHERRE
IQREILSILG	LPHRPRPFSP	GKQASSAPLF	MLDLYNAMTN	EENPEESEYS
VRASLAEETR	GARKGYPASP	NGYPRRIQLS	RTTPLTTQSP	PLASLHDTNF
LNDADMVMSF	VNLVERDKDF	SHQRRHYKEF	RFDLTQIPHG	EAVTAAEFRI
YKDRSNNRFE	NETIKISIYQ	IIKEYTNRDA	DLFLLDTRKA	QALDVGWLVF
DITVTSNHWV	INPQNNLGLQ	LCAETGDGRS	INVKSAGLVG	RQGPQSKQPF
MVAFFKASEV	LLRSVRAANK	RKNQNRNKSS	SHQDSSRMSS	VGDYNTSEQK
QACKKHELYV	SFRDLGWQDW	IIAPEGYAAF	YCDGECSFPL	NAHMNATNHA
IVQTLVHLMF	PDHVPKPCCA	PTKLNAISVL	YFDDSSNVIL	KKYRNMVVRS
CGCH

Funkcija

Protein kodiran ovim genom je član porodice TGFβ. Koštanomorfogenetski proteini poznati su po svojoj sposobnosti da induciraju razvoj kostiju i hrskavice. BMP5 može imati ulogu u određenim kancerima. Kao i drugi BMP, BMP5 inhibiraju hordin i nogin. Eksprimira se u trabekulskoj mreži i glavi očnog živca i može imati ulogu u razvoju i normalnoj funkciji. Također je eksprimiran u plućima i jetri.

Ovaj gen kodira člana porodice koštanomorfogenetskih proteina koja je dio natporodice transformirajućih faktora rasta beta. Natporodica uključuje velike porodice faktora rasta i diferencijacije. Koštanomorfogenetski proteini su prvobitno identifikovani sposobnošću demineralizovanog koštanog ekstrakta da indukuje endohrskavičnu osteogenezu in vivo na vanskeletnom mjestu. Ovi proteini sintetiziraju se kao prepropeptidi, cijepaju, a zatim procesuiraju u dimerne proteine. Može djelovati kao važna signalna molekula unutar trabekulske mreže i glave optičkog živca i imati potencijalnu ulogu u patogenezi glaukoma. Ovaj gen je različito regulisan tokom formiranja raznih tumora.^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112175 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032179 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (Nov 1992). "A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7". Genomics. 14 (3): 759–62. doi:10.1016/S0888-7543(05)80181-8. PMID 1427904.
^ Beck HN, Drahushuk K, Jacoby DB, Higgins D, Lein PJ (Mar 2003). "Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons". BMC Neuroscience. 2: 12. doi:10.1186/1471-2202-2-12. PMC 56999. PMID 11580864.
^ ^a ^b ^c "Entrez Gene: BMP5 bone morphogenetic protein 5".

Dopunska literatura

Celeste AJ, Iannazzi JA, Taylor RC, Hewick RM, Rosen V, Wang EA, Wozney JM (Dec 1990). "Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone". Proceedings of the National Academy of Sciences of the United States of America. 87 (24): 9843–7. Bibcode:1990PNAS...87.9843C. doi:10.1073/pnas.87.24.9843. PMC 55270. PMID 2263636.
Sakaue M, Kitazawa S, Nishida K, Kitazawa R, Maeda S (Apr 1996). "Molecular cloning and characterization of human bone morphogenic protein (BMP)-5 gene promoter". Biochemical and Biophysical Research Communications. 221 (3): 768–72. doi:10.1006/bbrc.1996.0671. PMID 8630036.
You L, Kruse FE, Pohl J, Völcker HE (Feb 1999). "Bone morphogenetic proteins and growth and differentiation factors in the human cornea". Investigative Ophthalmology & Visual Science. 40 (2): 296–311. PMID 9950587.
Imai N, Iwai A, Hatakeyama S, Matsuzaki K, Kitagawa Y, Kato S, Hokari R, Kawaguchi A, Nagao S, Miyahara T, Itoh K, Miura S (Aug 2001). "Expression of bone morphogenetic proteins in colon carcinoma with heterotopic ossification". Pathology International. 51 (8): 643–8. doi:10.1046/j.1440-1827.2001.01243.x. PMID 11564221. S2CID 35052100.
Jin Y, Lu HB, Liong E, Lau TY, Tipoe GL (Oct 2001). "Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors". Histology and Histopathology. 16 (4): 1013–9. PMID 11642720.
Cohen A, Mulas R, Seri M, Gaiero A, Fichera G, Marini M, Baffico M, Camera G (Jan 2002). "Meier-Gorlin syndrome (ear-patella-short stature syndrome) in an Italian patient: clinical evaluation and analysis of possible candidate genes". American Journal of Medical Genetics. 107 (1): 48–51. doi:10.1002/ajmg.10083. PMID 11807867.
Jiang FX, Stanley EG, Gonez LJ, Harrison LC (Feb 2002). "Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells". Journal of Cell Science. 115 (Pt 4): 753–60. doi:10.1242/jcs.115.4.753. PMID 11865031.
Luo J, Dunn T, Ewing C, Sauvageot J, Chen Y, Trent J, Isaacs W (maj 2002). "Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis". The Prostate. 51 (3): 189–200. doi:10.1002/pros.10087. PMID 11967953. S2CID 42730702.
Wordinger RJ, Agarwal R, Talati M, Fuller J, Lambert W, Clark AF (Jul 2002). "Expression of bone morphogenetic proteins (BMP), BMP receptors, and BMP associated proteins in human trabecular meshwork and optic nerve head cells and tissues". Molecular Vision. 8: 241–50. PMID 12131877.
Nakayama N, Han CY, Cam L, Lee JI, Pretorius J, Fisher S, Rosenfeld R, Scully S, Nishinakamura R, Duryea D, Van G, Bolon B, Yokota T, Zhang K (Jan 2004). "A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage". Development. 131 (1): 229–40. doi:10.1242/dev.00901. PMID 14660436.
Xu WP, Shiba H, Mizuno N, Uchida Y, Mouri Y, Kawaguchi H, Kurihara H (2005). "Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells". Cell Biology International. 28 (10): 675–82. doi:10.1016/j.cellbi.2004.06.004. PMID 15516325. S2CID 45261710.
Bobinac D, Marić I, Zoricić S, Spanjol J, Dordević G, Mustać E, Fuckar Z (Jun 2005). "Expression of bone morphogenetic proteins in human metastatic prostate and breast cancer". Croatian Medical Journal. 46 (3): 389–96. PMID 15861517.
Bramlage CP, Häupl T, Kaps C, Ungethüm U, Krenn V, Pruss A, Müller GA, Strutz F, Burmester GR (2006). "Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis". Arthritis Research & Therapy. 8 (3): R58. doi:10.1186/ar1923. PMC 1526630. PMID 16542506.
Wilkins JM, Southam L, Price AJ, Mustafa Z, Carr A, Loughlin J (Mar 2007). "Extreme context specificity in differential allelic expression". Human Molecular Genetics. 16 (5): 537–46. doi:10.1093/hmg/ddl488. PMID 17220169.

Vanjski linkovi

Lokacija ljudskog genoma BMP5 i stranica sa detaljima o genu BMP5 u UCSC Genome Browseru.

Šablon:Modulatori receptora TGFβ Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112175 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032179 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1427904-5] Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (Nov 1992). "A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7". Genomics. 14 (3): 759–62. doi:10.1016/S0888-7543(05)80181-8. PMID 1427904.

[pmid11580864-6] Beck HN, Drahushuk K, Jacoby DB, Higgins D, Lein PJ (Mar 2003). "Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons". BMC Neuroscience. 2: 12. doi:10.1186/1471-2202-2-12. PMC 56999. PMID 11580864.

[entrez-7] "Entrez Gene: BMP5 bone morphogenetic protein 5".

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