Alfa-taksilin

Alfa-taksilin
Identifikatori
Aliasi	TXLNA
Vanjski ID-jevi	OMIM: 608676 MGI: 105968 HomoloGene: 14062 GeneCards: TXLNA
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	32,198,285 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	129,534,858 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• cytokine activity; • syntaxin binding; • GO:0001948, GO:0016582 vezivanje za proteine; • high molecular weight B cell growth factor receptor binding;
Ćelijska komponenta	• citoplazma; • membrana; • extracellular region; • citosol;
Biološki proces	• B cell activation; • Ćelijska proliferacija; • Egzocitoza; • regulation of signaling receptor activity; • cytokine-mediated signaling pathway;
	Izvori:Amigo / QuickGO
Ortolozi
	200081
	109658
	ENSG00000084652
	ENSMUSG00000053841
	P40222
	Q6PAM1
	NM_175852; NM_001376857; NM_001376858; NM_001376859
	NM_001005506; NM_001199695
	NP_787048; NP_001363786; NP_001363787; NP_001363788
	NP_001005506; NP_001186624
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Alfa-taksilin, znan i kao interleukin-14 (IL-14) ili B-ćelijski faktor rasta visoke molelulske težine (HMW-BCGF) jest protein koji je kod ljudi kodiran genom TXLNA sa p kraka hromosoma 1.^[5]^[6]^[7]

Interleukin-14 je citokin koji kontrolira rast i proliferaciju normalnih i kancerogenih B-ćelija.^[8] Ova molekula je također nedavno nazvan taksilin.^[9] IL-14 inducira proliferaciju B-ćelija, inhibira lučenje antitijela i proširuje odabrane podgrupe B-ćelija. Ovaj interleukin proizvode uglavnom T-ćelije i određene malignw B-ćelije

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 546 aminokiseline, a molekulska težina 61.891 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MKNQDKKNGA	AKQSNPKSSP	GQPEAGPEGA	QERPSQAAPA	VEAEGPGSSQ
APRKPEGAQA	RTAQSGALRD	VSEELSRQLE	DILSTYCVDN	NQGGPGEDGA
QGEPAEPEDA	EKSRTYVARN	GEPEPTPVVN	GEKEPSKGDP	NTEEIRQSDE
VGDRDHRRPQ	EKKKAKGLGK	EITLLMQTLN	TLSTPEEKLA	ALCKKYAELL
EEHRNSQKQM	KLLQKKQSQL	VQEKDHLRGE	HSKAVLARSK	LESLCRELQR
HNRSLKEEGV	QRAREEEEKR	KEVTSHFQVT	LNDIQLQMEQ	HNERNSKLRQ
ENMELAERLK	KLIEQYELRE	EHIDKVFKHK	DLQQQLVDAK	LQQAQEMLKE
AEERHQREKD	FLLKEAVESQ	RMCELMKQQE	THLKQQLALY	TEKFEEFQNT
LSKSSEVFTT	FKQEMEKMTK	KIKKLEKETT	MYRSRWESSN	KALLEMAEEK
TVRDKELEGL	QVKIQRLEKL	CRALQTERND	LNKRVQDLSA	GGQGSLTDSG
PERRPEGPGA	QAPSSPRVTE	APCYPGAPST	EASGQTGPQE	PTSARA

Gen

U mišjim modelima, dva različita transkripta se proizvode iz suprotnih lanaca il14 gena koji se nazivaju IL-14α i IL-14β.^[10] Lokus il14 je kod ljudi blizu gena za LCK na hromosomu 1.

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000084652 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053841 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nogami S, Satoh S, Tanaka-Nakadate S, Yoshida K, Nakano M, Terano A, Shirataki H (Jun 2004). "Identification and characterization of taxilin isoforms". Biochem. Biophys. Res. Commun. 319 (3): 936–43. doi:10.1016/j.bbrc.2004.05.073. PMID 15184072.
^ Nogami S, Satoh S, Nakano M, Terano A, Shirataki H (Nov 2003). "Interaction of taxilin with syntaxin which does not form the SNARE complex". Biochem. Biophys. Res. Commun. 311 (4): 797–802. doi:10.1016/j.bbrc.2003.10.069. PMID 14623251.
^ ^a ^b "Entrez Gene: TXLNA taxilin alpha".
^ Ambrus JL, Pippin J, Joseph A, Xu C, Blumenthal D, Tamayo A, Claypool K, McCourt D, Srikiatchatochorn A, Ford RJ (juli 1993). "Identification of a cDNA for a human high-molecular-weight B-cell growth factor". Proc. Natl. Acad. Sci. U.S.A. 90 (13): 6330–4. Bibcode:1993PNAS...90.6330A. doi:10.1073/pnas.90.13.6330. PMC 46922. PMID 8327514.
^ Nogami S, Satoh S, Nakano M, Shimizu H, Fukushima H, Maruyama A, Terano A, Shirataki H (januar 2003). "Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells". Genes Cells. 8 (1): 17–28. doi:10.1046/j.1365-2443.2003.00612.x. PMID 12558796.
^ Shen L, Zhang C, Wang T, Brooks S, Ford RJ, Lin-Lee YC, Kasianowicz A, Kumar V, Martin L, Liang P, Cowell J, Ambrus JL (oktobar 2006). "Development of autoimmunity in IL-14alpha-transgenic mice". J. Immunol. 177 (8): 5676–86. doi:10.4049/jimmunol.177.8.5676. PMID 17015757. S2CID 86324456.

Vanjaski linkovi

Lokacija ljudskog genoma TXLNA i stranica sa detaljima o genu TXLNA u UCSC Genome Browseru.

Dopunska literatura

Ambrus JL, Pippin J, Joseph A, et al. (1993). "Identification of a cDNA for a human high-molecular-weight B-cell growth factor". Proc. Natl. Acad. Sci. U.S.A. 90 (13): 6330–4. Bibcode:1993PNAS...90.6330A. doi:10.1073/pnas.90.13.6330. PMC 46922. PMID 8327514.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Ambrus JL, Pippin J, Joseph A, et al. (1996). "Identification of a cDNA for a human high molecular-weight B-cell growth factor". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 8154. PMC 38894. PMID 8755619.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nogami S, Satoh S, Nakano M, et al. (2003). "Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells". Genes Cells. 8 (1): 17–28. doi:10.1046/j.1365-2443.2003.00612.x. PMID 12558796.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Shen L, Zhang C, Wang T, et al. (2007). "Development of autoimmunity in IL-14alpha-transgenic mice". J. Immunol. 177 (8): 5676–86. doi:10.4049/jimmunol.177.8.5676. PMID 17015757. S2CID 86324456.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000084652 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000053841 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15184072-5] Nogami S, Satoh S, Tanaka-Nakadate S, Yoshida K, Nakano M, Terano A, Shirataki H (Jun 2004). "Identification and characterization of taxilin isoforms". Biochem. Biophys. Res. Commun. 319 (3): 936–43. doi:10.1016/j.bbrc.2004.05.073. PMID 15184072.

[pmid14623251-6] Nogami S, Satoh S, Nakano M, Terano A, Shirataki H (Nov 2003). "Interaction of taxilin with syntaxin which does not form the SNARE complex". Biochem. Biophys. Res. Commun. 311 (4): 797–802. doi:10.1016/j.bbrc.2003.10.069. PMID 14623251.

[entrez-7] "Entrez Gene: TXLNA taxilin alpha".

[pmid8327514-8] Ambrus JL, Pippin J, Joseph A, Xu C, Blumenthal D, Tamayo A, Claypool K, McCourt D, Srikiatchatochorn A, Ford RJ (juli 1993). "Identification of a cDNA for a human high-molecular-weight B-cell growth factor". Proc. Natl. Acad. Sci. U.S.A. 90 (13): 6330–4. Bibcode:1993PNAS...90.6330A. doi:10.1073/pnas.90.13.6330. PMC 46922. PMID 8327514.

[pmid12558796-9] Nogami S, Satoh S, Nakano M, Shimizu H, Fukushima H, Maruyama A, Terano A, Shirataki H (januar 2003). "Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells". Genes Cells. 8 (1): 17–28. doi:10.1046/j.1365-2443.2003.00612.x. PMID 12558796.

[pmid17015757-10] Shen L, Zhang C, Wang T, Brooks S, Ford RJ, Lin-Lee YC, Kasianowicz A, Kumar V, Martin L, Liang P, Cowell J, Ambrus JL (oktobar 2006). "Development of autoimmunity in IL-14alpha-transgenic mice". J. Immunol. 177 (8): 5676–86. doi:10.4049/jimmunol.177.8.5676. PMID 17015757. S2CID 86324456.

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