ART3

ART3
Identifikatori
Aliasi	ART3
Vanjski ID-jevi	OMIM: 603086 MGI: 1202729 HomoloGene: 911 GeneCards: ART3
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	76,112,802 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	92,562,487 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• NAD+ ADP-ribosyltransferase activity; • glycosyltransferase activity; • GO:0106274 NAD+-protein-arginine ADP-ribosyltransferase activity; • aktivnost sa transferazom;
Ćelijska komponenta	• anchored component of membrane; • membrana; • integral component of plasma membrane; • Egzosom; • extracellular region; • ćelijska membrana; • intrinsic component of plasma membrane;
Biološki proces	• protein ADP-ribosylation; • C-terminal protein lipidation; • peptidyl-arginine ADP-ribosylation;
	Izvori:Amigo / QuickGO
Ortolozi
	419
	109979
	ENSG00000156219
	ENSMUSG00000034842
	Q13508
	Q8R2G4
	NM_001130016; NM_001130017; NM_001179
	NM_181728; NM_001310664; NM_001310665; NM_001370591
NP_001123488; NP_001123489; NP_001170; NP_001364102; NP_001364103;
	NP_001364104; NP_001364105; NP_001364106; NP_001364107; NP_001364108; NP_001364109; NP_001364110; NP_001364111; NP_001364112; NP_001364113; NP_001364114
	NP_001297593; NP_001297594; NP_859417; NP_001357520
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Ekto-ADP-riboziltransferaza 3 jest enzim koji je kod ljudi kodiran genom ART3 sa hromosoma 4.^[5]^[6]

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 389 aminokiselina, а molekulska težina 43.923 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MKTGHFEIVT	MLLATMILVD	IFQVKAEVLD	MADNAFDDEY	LKCTDRMEIK
YVPQLLKEEK	ASHQQLDTVW	ENAKAKWAAR	KTQIFLPMNF	KDNHGIALMA
YISEAQEQTP	FYHLFSEAVK	MAGQSREDYI	YGFQFKAFHF	YLTRALQLLR
KPCEASSKTV	VYRTSQGTSF	TFGGLNQARF	GHFTLAYSAK	PQAANDQLTV
LSIYTCLGVD	IENFLDKESE	RITLIPLNEV	FQVSQEGAGN	NLILQSINKT
CSHYECAFLG	GLKTENCIEN	LEYFQPIYVY	NPGEKNQKLE	DHSEKNWKLE
DHGEKNQKLE	DHGVKILEPT	QIPGMKIPEP	FPLPEDKSQG	NINNPTPGPV
PVPGPKSHPS	ASSGKLLLPQ	FGMVIILISV	SAINLFVAL

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000156219 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034842 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Koch-Nolte F, Haag F, Braren R, Kühl M, Hoovers J, Balasubramanian S, Bazan F, Thiele HG (1997). "Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins". Genomics. 39 (3): 370–6. doi:10.1006/geno.1996.4520. PMID 9119374.
^ "Entrez Gene: ART3 ADP-ribosyltransferase 3".
^ "UniProt, Q13508" (jezik: engleski). Pristupljeno 22. 10. 2021.

Dopunska literatura uredi

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Lévy I, Wu YQ, Roeckel N, Bulle F, Pawlak A, Siegrist S, Mattéi MG, Guellaën G (1996). "Human testis specifically expresses a homologue of the rodent T lymphocytes RT6 mRNA". FEBS Lett. 382 (3): 276–80. doi:10.1016/0014-5793(96)00183-4. PMID 8605984. S2CID 1083606.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Balducci E, Horiba K, Usuki J, Park M, Ferrans VJ, Moss J (1999). "Selective expression of RT6 superfamily in human bronchial epithelial cells". Am. J. Respir. Cell Mol. Biol. 21 (3): 337–46. CiteSeerX 10.1.1.325.7458. doi:10.1165/ajrcmb.21.3.3638. PMID 10460751.
Grahnert A, Friedrich M, Pfister M, Haag F, Koch-Nolte F, Hauschildt S (2002). "Mono-ADP-ribosyltransferases in human monocytes: regulation by lipopolysaccharide". Biochem. J. 362 (Pt 3): 717–23. doi:10.1042/0264-6021:3620717. PMC 1222437. PMID 11879200.
Glowacki G, Braren R, Firner K, Nissen M, Kühl M, Reche P, Bazan F, Cetkovic-Cvrlje M, Leiter E, Haag F, Koch-Nolte F (2002). "The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse". Protein Sci. 11 (7): 1657–70. doi:10.1110/ps.0200602. PMC 2373659. PMID 12070318.
Friedrich M, Grahnert A, Paasch U, Tannapfel A, Koch-Nolte F, Hauschildt S (2006). "Expression of toxin-related human mono-ADP-ribosyltransferase 3 in human testes". Asian J. Androl. 8 (3): 281–7. doi:10.1111/j.1745-7262.2006.00125.x. PMID 16625277.
Friedrich M, Grahnert A, Klein C, Tschöp K, Engeland K, Hauschildt S (2006). "Genomic organization and expression of the human mono-ADP-ribosyltransferase ART3 gene". Biochim. Biophys. Acta. 1759 (6): 270–80. doi:10.1016/j.bbaexp.2006.06.004. PMID 16934346.

Vanjski linkovi uredi

Lokacija ljudskog genoma ART3 i stranica sa detaljima o genu ART3 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000156219 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034842 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9119374-5] Koch-Nolte F, Haag F, Braren R, Kühl M, Hoovers J, Balasubramanian S, Bazan F, Thiele HG (1997). "Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins". Genomics. 39 (3): 370–6. doi:10.1006/geno.1996.4520. PMID 9119374.

[entrez-6] "Entrez Gene: ART3 ADP-ribosyltransferase 3".

[UniProt-7] "UniProt, Q13508" (jezik: engleski). Pristupljeno 22. 10. 2021.

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