AMP-deaminaza 2

AMP-deaminaza 2 jest enzim koji je kod ljudi kodiran genom AMPD2 sa hromosoma 1.[5][6]

AMP-deaminaza 2
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

4NO3, 4NO5

Identifikatori
AliasiAMPD2
Vanjski ID-jeviOMIM: 102771 MGI: 88016 HomoloGene: 2979 GeneCards: AMPD2
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za AMP-deaminaza 2
Genomska lokacija za AMP-deaminaza 2
Bend1p13.3Početak109,616,104 bp[1]
Kraj109,632,051 bp[1]
Lokacija gena (miš)
Hromosom 3 (miš)
Hrom.Hromosom 3 (miš)[2]
Hromosom 3 (miš)
Genomska lokacija za AMP-deaminaza 2
Genomska lokacija za AMP-deaminaza 2
Bend3 F2.3|3 46.83 cMPočetak107,981,378 bp[2]
Kraj107,993,967 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija hydrolase activity
vezivanje iona metala
deaminase activity
GO:0001948, GO:0016582 vezivanje za proteine
AMP deaminase activity
Ćelijska komponenta ćelijska komponenta
citosol
Biološki proces purine ribonucleoside monophosphate biosynthetic process
IMP salvage
cyclic purine nucleotide metabolic process
nucleotide metabolic process
purine-containing compound salvage
IMP biosynthetic process
energy homeostasis
AMP metabolic process
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)
NM_001257360
NM_001257361
NM_001308170
NM_004037
NM_139156

NM_203404
NM_001368809

NM_001289719
NM_001289720
NM_028779
NM_001346665

RefSeq (bjelančevina)
NP_001244289
NP_001244290
NP_001295099
NP_004028
NP_631895

NP_001355738

NP_001276648
NP_001276649
NP_001333594
NP_083055

Lokacija (UCSC)Chr 1: 109.62 – 109.63 MbChr 3: 107.98 – 107.99 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Amiokiselininska sekvenca

uredi

Dužina polipeptidnog lanca je 879 aminokiselina, a molekulska težina 100.688 Da.[7]

1020304050
MRNRGQGLFRLRSRCFLHQSLPLGAGRRKGLDVAEPGPSRCRSDSPAVAA
VVPAMASYPSGSGKPKAKYPFKKRASLQASTAAPEARGGLGAPPLQSARS
LPGPAPCLKHFPLDLRTSMDGKCKEIAEELFTRSLAESELRSAPYEFPEE
SPIEQLEERRQRLERQISQDVKLEPDILLRAKQDFLKTDSDSDLQLYKEQ
GEGQGDRSLRERDVLEREFQRVTISGEEKCGVPFTDLLDAAKSVVRALFI
REKYMALSLQSFCPTTRRYLQQLAEKPLETRTYEQGPDTPVSADAPVHPP
ALEQHPYEHCEPSTMPGDLGLGLRMVRGVVHVYTRREPDEHCSEVELPYP
DLQEFVADVNVLMALIINGPIKSFCYRRLQYLSSKFQMHVLLNEMKELAA
QKKVPHRDFYNIRKVDTHIHASSCMNQKHLLRFIKRAMKRHLEEIVHVEQ
GREQTLREVFESMNLTAYDLSVDTLDVHADRNTFHRFDKFNAKYNPIGES
VLREIFIKTDNRVSGKYFAHIIKEVMSDLEESKYQNAELRLSIYGRSRDE
WDKLARWAVMHRVHSPNVRWLVQVPRLFDVYRTKGQLANFQEMLENIFLP
LFEATVHPASHPELHLFLEHVDGFDSVDDESKPENHVFNLESPLPEAWVE
EDNPPYAYYLYYTFANMAMLNHLRRQRGFHTFVLRPHCGEAGPIHHLVSA
FMLAENISHGLLLRKAPVLQYLYYLAQIGIAMSPLSNNSLFLSYHRNPLP
EYLSRGLMVSLSTDDPLQFHFTKEPLMEEYSIATQVWKLSSCDMCELARN
SVLMSGFSHKVKSHWLGPNYTKEGPEGNDIRRTNVPDIRVGYRYETLCQE
LALITQAVQSEMLETIPEEAGITMSPGPQ

Funkcija

uredi

Visoki nivoi ekspresije AMPD2 koreliraju sa lošim ishodom pacijenata i proliferativnim tumorskim fenotipom kod nediferenciranog pleomorfnog sarkoma (UPS).[8]

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116337 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027889 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mahnke-Zizelman DK, Sabina RL (Nov 1992). "Cloning of human AMP deaminase isoform E cDNAs. Evidence for a third AMPD gene exhibiting alternatively spliced 5'-exons". J Biol Chem. 267 (29): 20866–77. doi:10.1016/S0021-9258(19)36768-7. PMID 1400401.
  6. ^ "Entrez Gene: AMPD2 adenosine monophosphate deaminase 2 (isoform L)".
  7. ^ "UniProt, Q01433" (jezik: engleski). Pristupljeno 21. 11. 2021.
  8. ^ Orth MF, Gerke JS, Knösel T, Altendorf-Hofmann A, Musa J, Alba-Rubio R, et al. (septembar 2018). "Functional genomics identifies AMPD2 as a new prognostic marker for undifferentiated pleomorphic sarcoma". International Journal of Cancer. 144 (4): 859–867. doi:10.1002/ijc.31903. PMID 30267407.

Dopunska literatura

uredi

Vanjski linkovi

uredi

Šablon:Enzimi metabolizma nukteotida