AMP-deaminaza 2
AMP-deaminaza 2 jest enzim koji je kod ljudi kodiran genom AMPD2 sa hromosoma 1.[5][6]
Amiokiselininska sekvenca
urediDužina polipeptidnog lanca je 879 aminokiselina, a molekulska težina 100.688 Da.[7]
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MRNRGQGLFR | LRSRCFLHQS | LPLGAGRRKG | LDVAEPGPSR | CRSDSPAVAA | ||||
VVPAMASYPS | GSGKPKAKYP | FKKRASLQAS | TAAPEARGGL | GAPPLQSARS | ||||
LPGPAPCLKH | FPLDLRTSMD | GKCKEIAEEL | FTRSLAESEL | RSAPYEFPEE | ||||
SPIEQLEERR | QRLERQISQD | VKLEPDILLR | AKQDFLKTDS | DSDLQLYKEQ | ||||
GEGQGDRSLR | ERDVLEREFQ | RVTISGEEKC | GVPFTDLLDA | AKSVVRALFI | ||||
REKYMALSLQ | SFCPTTRRYL | QQLAEKPLET | RTYEQGPDTP | VSADAPVHPP | ||||
ALEQHPYEHC | EPSTMPGDLG | LGLRMVRGVV | HVYTRREPDE | HCSEVELPYP | ||||
DLQEFVADVN | VLMALIINGP | IKSFCYRRLQ | YLSSKFQMHV | LLNEMKELAA | ||||
QKKVPHRDFY | NIRKVDTHIH | ASSCMNQKHL | LRFIKRAMKR | HLEEIVHVEQ | ||||
GREQTLREVF | ESMNLTAYDL | SVDTLDVHAD | RNTFHRFDKF | NAKYNPIGES | ||||
VLREIFIKTD | NRVSGKYFAH | IIKEVMSDLE | ESKYQNAELR | LSIYGRSRDE | ||||
WDKLARWAVM | HRVHSPNVRW | LVQVPRLFDV | YRTKGQLANF | QEMLENIFLP | ||||
LFEATVHPAS | HPELHLFLEH | VDGFDSVDDE | SKPENHVFNL | ESPLPEAWVE | ||||
EDNPPYAYYL | YYTFANMAML | NHLRRQRGFH | TFVLRPHCGE | AGPIHHLVSA | ||||
FMLAENISHG | LLLRKAPVLQ | YLYYLAQIGI | AMSPLSNNSL | FLSYHRNPLP | ||||
EYLSRGLMVS | LSTDDPLQFH | FTKEPLMEEY | SIATQVWKLS | SCDMCELARN | ||||
SVLMSGFSHK | VKSHWLGPNY | TKEGPEGNDI | RRTNVPDIRV | GYRYETLCQE | ||||
LALITQAVQS | EMLETIPEEA | GITMSPGPQ |
Funkcija
urediVisoki nivoi ekspresije AMPD2 koreliraju sa lošim ishodom pacijenata i proliferativnim tumorskim fenotipom kod nediferenciranog pleomorfnog sarkoma (UPS).[8]
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000116337 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027889 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mahnke-Zizelman DK, Sabina RL (Nov 1992). "Cloning of human AMP deaminase isoform E cDNAs. Evidence for a third AMPD gene exhibiting alternatively spliced 5'-exons". J Biol Chem. 267 (29): 20866–77. doi:10.1016/S0021-9258(19)36768-7. PMID 1400401.
- ^ "Entrez Gene: AMPD2 adenosine monophosphate deaminase 2 (isoform L)".
- ^ "UniProt, Q01433" (jezik: engleski). Pristupljeno 21. 11. 2021.
- ^ Orth MF, Gerke JS, Knösel T, Altendorf-Hofmann A, Musa J, Alba-Rubio R, et al. (septembar 2018). "Functional genomics identifies AMPD2 as a new prognostic marker for undifferentiated pleomorphic sarcoma". International Journal of Cancer. 144 (4): 859–867. doi:10.1002/ijc.31903. PMID 30267407.
Dopunska literatura
uredi- Bausch-Jurken MT, Mahnke-Zizelman DK, Morisaki T, Sabina RL (1992). "Molecular cloning of AMP deaminase isoform L. Sequence and bacterial expression of human AMPD2 cDNA". J. Biol. Chem. 267 (31): 22407–13. doi:10.1016/S0021-9258(18)41686-9. PMID 1429593.
- Van den Bergh F, Sabina RL (1996). "Characterization of human AMP deaminase 2 (AMPD2) gene expression reveals alternative transcripts encoding variable N-terminal extensions of isoform L". Biochem. J. 312 (Pt 2): 401–10. doi:10.1042/bj3120401. PMC 1136276. PMID 8526848.
- Mahnke-Zizelman DK, van den Bergh F, Bausch-Jurken MT, et al. (1996). "Cloning, sequence and characterization of the human AMPD2 gene: evidence for transcriptional regulation by two closely spaced promoters". Biochim. Biophys. Acta. 1308 (2): 122–32. doi:10.1016/0167-4781(96)00089-9. PMID 8764830.
- Haas AL, Sabina RL (2003). "N-terminal extensions of the human AMPD2 polypeptide influence ATP regulation of isoform L". Biochem. Biophys. Res. Commun. 305 (2): 421–7. doi:10.1016/S0006-291X(03)00787-3. PMID 12745092.
- Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Vanjski linkovi
uredi- Lokacija ljudskog genoma AMPD2 i stranica sa detaljima o genu AMPD2 u UCSC Genome Browseru.