ADM2

ADM2
Identifikatori
Aliasi	ADM2
Vanjski ID-jevi	OMIM: 608682 MGI: 2675256 HomoloGene: 49801 GeneCards: ADM2
Lokacija gena (čovjek)
Hrom.	Hromosom 22 (čovjek)
Kraj	50,486,440 bp
Lokacija gena (miš)
Hrom.	Hromosom 15 (miš)
Kraj	89,208,934 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• hormone activity; • GO:0032403 protein-containing complex binding;
Ćelijska komponenta	• extracellular region; • intracellular anatomical structure;
Biološki proces	• varenje; • protein phosphorylation; • GO:1901313 positive regulation of gene expression; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • Angiogeneza; • ponašanje pri hranjenju; • positive regulation of angiogenesis; • negative regulation of blood pressure; • regulation of signaling receptor activity; • G protein-coupled receptor signaling pathway;
	Izvori:Amigo / QuickGO
Ortolozi
	79924
	223780
	ENSG00000128165
	ENSMUSG00000054136
	Q7Z4H4
	Q7TNK8
	NM_024866; NM_001253845; NM_001369882
	NM_182928
	NP_001240774; NP_001356811
	NP_891558
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

ADM2 jest protein koji je kod ljudi kodiran genom ADM2 sa hromosoma 22.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 148 aminokiselina, a molekulska težina 15.865 Da.

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MARIPTAALG	CISLLCLQLP	GSLSRSLGGD	PRPVKPREPP	ARSPSSSLQP
RHPAPRPVVW	KLHRALQAQR	GAGLAPVMGQ	PLRDGGRQHS	GPRRHSGPRR
TQAQLLRVGC	VLGTCQVQNL	SHRLWQLMGP	AGRQDSAPVD	PSSPHSYG

Funkcija

ADM2 pripada porodici kalcitoninskih (MIM 114130) povezanih peptidnih hormona važnih za regulaciju različitih fizioloških funkcija i hemijskog sastava tečnosti i tkiva (prema OMIM^[6])

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000128165 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054136 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Takei Y, Inoue K, Ogoshi M, Kawahara T, Bannai H, Miyano S (Jan 2004). "Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator". FEBS Lett. 556 (1–3): 53–8. doi:10.1016/S0014-5793(03)01368-1. PMID 14706825. S2CID 2063665.
^ ^a ^b "Entrez Gene: ADM2 adrenomedullin 2".

Dopumska literatura

Kawai M (2004). "[Diagnosis of dermatophytoses: conventional methods and recent molecular biological methods]". Nihon Ishinkin Gakkai Zasshi (Japanese Journal of Medical Mycology). 44 (4): 261–4. doi:10.3314/jjmm.44.261. PMID 14615790.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Roh J, Chang CL, Bhalla A, et al. (2004). "Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes". J. Biol. Chem. 279 (8): 7264–74. doi:10.1074/jbc.M305332200. PMID 14615490.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Takahashi K, Kikuchi K, Maruyama Y, et al. (2006). "Immunocytochemical localization of adrenomedullin 2/intermedin-like immunoreactivity in human hypothalamus, heart and kidney". Peptides. 27 (6): 1383–9. doi:10.1016/j.peptides.2005.11.004. PMID 16359754. S2CID 27665694.
Kindt F, Wiegand S, Löser C, et al. (2007). "Intermedin: a skin peptide that is downregulated in atopic dermatitis". J. Invest. Dermatol. 127 (3): 605–13. doi:10.1038/sj.jid.5700576. PMID 17008878.
Morimoto R, Satoh F, Murakami O, et al. (2007). "Expression of adrenomedullin2/intermedin in human brain, heart, and kidney". Peptides. 28 (5): 1095–103. doi:10.1016/j.peptides.2007.01.018. PMID 17346853. S2CID 23005775.

Vanjski linkovi

Lokacija ljudskog genoma ADM2 i stranica sa detaljima o genu ADM2 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000128165 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054136 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14706825-5] Takei Y, Inoue K, Ogoshi M, Kawahara T, Bannai H, Miyano S (Jan 2004). "Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator". FEBS Lett. 556 (1–3): 53–8. doi:10.1016/S0014-5793(03)01368-1. PMID 14706825. S2CID 2063665.

[entrez-6] "Entrez Gene: ADM2 adrenomedullin 2".

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