ACSM3
Mitohondrijska acil-koenzim A-sintetaza ACSM3 jest enzim koji je kod ljudi kodiran genom ACSM3.[5][6][7][8]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 586 aminokiselina, a molekulska težina 66.153 Da.[9]
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MLARVTRKML | RHAKCFQRLA | IFGSVRALHK | DNRTATPQNF | SNYESMKQDF | ||||
| KLGIPEYFNF | AKDVLDQWTD | KEKAGKKPSN | PAFWWINRNG | EEMRWSFEEL | ||||
| GSLSRKFANI | LSEACSLQRG | DRVILILPRV | PEWWLANVAC | LRTGTVLIPG | ||||
| TTQLTQKDIL | YRLQSSKANC | IITNDVLAPA | VDAVASKCEN | LHSKLIVSEN | ||||
| SREGWGNLKE | LMKHASDSHT | CVKTKHNEIM | AIFFTSGTSG | YPKMTAHTHS | ||||
| SFGLGLSVNG | RFWLDLTPSD | VMWNTSDTGW | AKSAWSSVFS | PWIQGACVFT | ||||
| HHLPRFEPTS | ILQTLSKYPI | TVFCSAPTVY | RMLVQNDITS | YKFKSLKHCV | ||||
| SAGEPITPDV | TEKWRNKTGL | DIYEGYGQTE | TVLICGNFKG | MKIKPGSMGK | ||||
| PSPAFDVKIV | DVNGNVLPPG | QEGDIGIQVL | PNRPFGLFTH | YVDNPSKTAS | ||||
| TLRGNFYITG | DRGYMDKDGY | FWFVARADDV | ILSSGYRIGP | FEVENALNEH | ||||
| PSVAESAVVS | SPDPIRGEVV | KAFVVLNPDY | KSHDQEQLIK | EIQEHVKKTT | ||||
| APYKYPRKVE | FIQELPKTIS | GKTKRNELRK | KEWKTI |
Reference uredi
- ^ a b c GRCh38: Ensembl release 89: ENSG00000005187 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030935 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Nabika T, Bonnardeaux A, James M, Julier C, Jeunemaitre X, Corvol P, Lathrop M, Soubrier F (Jan 1995). "Evaluation of the SA locus in human hypertension". Hypertension. 25 (1): 6–13. doi:10.1161/01.hyp.25.1.6. PMID 7843754.
- ^ Iwai N, Ohmichi N, Hanai K, Nakamura Y, Kinoshita M (Mar 1994). "Human SA gene locus as a candidate locus for essential hypertension". Hypertension. 23 (3): 375–80. doi:10.1161/01.hyp.23.3.375. PMID 7907320.
- ^ Fujino T, Takei YA, Sone H, Ioka RX, Kamataki A, Magoori K, Takahashi S, Sakai J, Yamamoto TT (Sep 2001). "Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product". The Journal of Biological Chemistry. 276 (38): 35961–6. doi:10.1074/jbc.M106651200. PMID 11470804.
- ^ "Entrez Gene: ACSM3 acyl-CoA synthetase medium-chain family member 3".
- ^ "UniProt, Q53FZ2". Pristupljeno 30. 6. 2021.
Vanjski linkovi uredi
- Lokacija ljudskog genoma ACSM3 i stranica sa detaljima o genu ACSM3 u UCSC Genome Browseru.
Dopunska literatura uredi
- Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Samani NJ, Whitmore SA, Kaiser MA, Harris J, See CG, Callen DF, Lodwick D (Mar 1994). "Chromosomal assignment of the human SA gene to 16p13.11 and demonstration of its expression in the kidney". Biochemical and Biophysical Research Communications. 199 (2): 862–8. doi:10.1006/bbrc.1994.1308. PMID 8135833.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (Sep 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
- Iwai N, Katsuya T, Mannami T, Higaki J, Ogihara T, Kokame K, Ogata J, Baba S (Jan 2002). "Association between SAH, an acyl-CoA synthetase gene, and hypertriglyceridemia, obesity, and hypertension". Circulation. 105 (1): 41–7. doi:10.1161/hc0102.101780. PMID 11772874.
- Narita I, Saito N, Goto S, Shirasaki A, Morioka Y, Jin S, Omori K, Sakatsume M, Arakawa M, Gejyo F (Nov 2002). "Role of genetic polymorphism in the SA gene on the blood pressure and prognosis of renal function in patients with immunoglobulin A nephropathy". Hypertension Research. 25 (6): 831–6. doi:10.1291/hypres.25.831. PMID 12484505.
- Benjafield AV, Iwai N, Ishikawa K, Wang WY, Morris BJ (Aug 2003). "Overweight, but not hypertension, is associated with SAH polymorphisms in Caucasians with essential hypertension". Hypertension Research. 26 (8): 591–5. doi:10.1291/hypres.26.591. PMID 14567496.
- Telgmann R, Brand E, Nicaud V, Hagedorn C, Beining K, Schönfelder J, Brink-Spalink V, Schmidt-Petersen K, Matanis T, Vischer P, Nofer JR, Hasenkamp S, Plouin PF, Drouet L, Cambien F, Paul M, Tiret L, Brand-Herrmann SM (Mar 2007). "SAH gene variants are associated with obesity-related hypertension in Caucasians: the PEGASE Study". Journal of Hypertension. 25 (3): 557–64. doi:10.1097/HJH.0b013e3280144779. PMID 17278971. S2CID 39465138.