ZNF521

Cinkoprstni protein 521 je protein koji je kod ljudi kodiran genom ZNF521.

ZNF521
Identifikatori
Aliasi	ZNF521
Vanjski ID-jevi	OMIM: 610974 MGI: 95459 HomoloGene: 9151 GeneCards: ZNF521
Lokacija gena (čovjek) Hrom. Hromosom 18 (čovjek) Bend 18q11.2 Početak 25,061,924 bp Kraj 25,352,190 bp
Lokacija gena (miš) Hrom. Hromosom 18 (miš) Bend 18 A1|18 7.68 cM Početak 13,820,070 bp Kraj 14,105,844 bp
Ontologija gena Molekularna funkcija • vezivanje sa DNK • protein domain specific binding • vezivanje iona metala • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • jedro • extracellular region Biološki proces • multicellular organism development • neuron fate commitment • Ćelijska diferencijacija • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • negative regulation of endopeptidase activity Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	25925	225207
Ensembl	ENSG00000198795	ENSMUSG00000024420
UniProt	Q96K83 Q8IYZ2	Q6KAS7
RefSeq (mRNK)	NM_001308225 NM_015461	NM_145492 NM_001360804
RefSeq (bjelančevina)	NP_001295154 NP_056276 NP_001295154.1	NP_663467 NP_001347733
Lokacija (UCSC)	Chr 18: 25.06 – 25.35 Mb	Chr 18: 13.82 – 14.11 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Dužina polipeptidnog lanca je 1.311 aminokiselina, sa molekulskom težinom od 147.866.

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MSRRKQAKPR		SLKDPNCKLE		DKTEDGEALD		CKKRPEDGEE		LEDEAVHSCD
SCLQVFESLS		DITEHKINQC		QLTDGVDVED		DPTCSWPASS		PSSKDQTSPS
HGEGCDFGEE		EGGPGLPYPC		QFCDKSFSRL		SYLKHHEQSH		SDKLPFKCTY
CSRLFKHKRS		RDRHIKLHTG		DKKYHCSECD		AAFSRSDHLK		IHLKTHTSNK
PYKCAICRRG		FLSSSSLHGH		MQVHERNKDG		SQSGSRMEDW		KMKDTQKCSQ
CEEGFDFPED		LQKHIAECHP		ECSPNEDRAA		LQCVYCHELF		VEETSLMNHM
EQVHSGEKKN		SCSICSESFH		TVEELYSHMD		SHQQPESCNH		SNSPSLVTVG
YTSVSSTTPD		SNLSVDSSTM		VEAAPPIPKS		RGRKRAAQQT		PDMTGPSSKQ
AKVTYSCIYC		NKQLFSSLAV		LQIHLKTMHL		DKPEQAHICQ		YCLEVLPSLY
NLNEHLKQVH		EAQDPGLIVS		AMPAIVYQCN		FCSEVVNDLN		TLQEHIRCSH
GFANPAAKDS		NAFFCPHCYM		GFLTDSSLEE		HIRQVHCDLS		GSRFGSPVLG
TPKEPVVEVY		SCSYCTNSPI		FNSVLKLNKH		IKENHKNIPL		ALNYIHNGKK
SRALSPLSPV		AIEQTSLKMM		QAVGGAPARP		TGEYICNQCG		AKYTSLDSFQ
THLKTHLDTV		LPKLTCPQCN		KEFPNQESLL		KHVTIHFMIT		STYYICESCD
KQFTSVDDLQ		KHLLDMHTFV		FFRCTLCQEV		FDSKVSIQLH		LAVKHSNEKK
VYRCTSCNWD		FRNETDLQLH		VKHNHLENQG		KVHKCIFCGE		SFGTEVELQC
HITTHSKKYN		CKFCSKAFHA		IILLEKHLRE		KHCVFETKTP		NCGTNGASEQ
VQKEEVELQT		LLTNSQESHN		SHDGSEEDVD		TSEPMYGCDI		CGAAYTMETL
LQNHQLRDHN		IRPGESAIVK		KKAELIKGNY		KCNVCSRTFF		SENGLREHMQ
THLGPVKHYM		CPICGERFPS		LLTLTEHKVT		HSKSLDTGNC		RICKMPLQSE
EEFLEHCQMH		PDLRNSLTGF		RCVVCMQTVT		STLELKIHGT		FHMQKTGNGS
AVQTTGRGQH		VQKLYKCASC		LKEFRSKQDL		VKLDINGLPY		GLCAGCVNLS
KSASPGINVP		PGTNRPGLGQ		NENLSAIEGK		GKVGGLKTRC		SSCNVKFESE
SELQNHIQTI		HRELVPDSNS		TQLKTPQVSP		MPRISPSQSD		EKKTYQCIKC
QMVFYNEWDI		QVHVANHMID		EGLNHECKLC		SQTFDSPAKL		QCHLIEHSFE
GMGGTFKCPV		CFTVFVQANK		LQQHIFSAHG		QEDKIYDCTQ		CPQKFFFQTE
LQNHTMTQHS		S

Funkcija

Proteini cinkovog prsta vežu nukleinske kiseline i imaju važnu ulogu u različitim ćelijskim funkcijama, uključujući proliferacija ćelija, diferencijacija i apoptozu. Ovaj gen kodira protein cinkovog prsta i pripada porodici proteina cinka-prsta tipa Krüppel C2H2. Može biti uključen u proces transkripcije.

Dopunska literatura

• La Rocca R, Fulciniti M, Lakshmikanth T, Mesuraca M, Ali TH, Mazzei V, Amodio N, Catalano L, Rotoli B, Ouerfelli O, Grieco M, Gulletta E, Bond HM, Morrone G, Ferrone S, Carbone E (april 2009). "Early hematopoietic zinc finger protein prevents tumor cell recognition by natural killer cells". Journal of Immunology. 182 (8): 4529–37. doi:10.4049/jimmunol.0802109. PMC 2747523. PMID 19342626.
• Bond HM, Mesuraca M, Amodio N, Mega T, Agosti V, Fanello D, Pelaggi D, Bullinger L, Grieco M, Moore MA, Venuta S, Morrone G (2008). "Early hematopoietic zinc finger protein-zinc finger protein 521: a candidate regulator of diverse immature cells". The International Journal of Biochemistry & Cell Biology. 40 (5): 848–54. doi:10.1016/j.biocel.2007.04.006. PMID 17543573.
• Warming S, Liu P, Suzuki T, Akagi K, Lindtner S, Pavlakis GN, Jenkins NA, Copeland NG (mart 2003). "Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related Krüppel-like zinc finger protein". Blood. 101 (5): 1934–40. doi:10.1182/blood-2002-08-2652. PMID 12393497.
• Matsubara E, Sakai I, Yamanouchi J, Fujiwara H, Yakushijin Y, Hato T, Shigemoto K, Yasukawa M (februar 2009). "The role of zinc finger protein 521/early hematopoietic zinc finger protein in erythroid cell differentiation". The Journal of Biological Chemistry. 284 (6): 3480–7. doi:10.1074/jbc.M805874200. PMID 19049973.
• Bond HM, Mesuraca M, Carbone E, Bonelli P, Agosti V, Amodio N, De Rosa G, Di Nicola M, Gianni AM, Moore MA, Hata A, Grieco M, Morrone G, Venuta S (mart 2004). "Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells". Blood. 103 (6): 2062–70. doi:10.1182/blood-2003-07-2388. PMID 14630787.
• McCormack M, Urban TJ, Shianna KV, Walley N, Pandolfo M, Depondt C, Chaila E, O'Conner GD, Kasperavičiūtė D, Radtke RA, Heinzen EL, Sisodiya SM, Delanty N, Cavalleri GL (mart 2012). "Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions". Pharmacogenomics. 13 (4): 399–405. doi:10.2217/pgs.11.165. PMC 3428903. PMID 22379998.
• Hesse E, Kiviranta R, Wu M, Saito H, Yamana K, Correa D, Atfi A, Baron R (mart 2010). "Zinc finger protein 521, a new player in bone formation". Annals of the New York Academy of Sciences. 1192: 32–7. doi:10.1111/j.1749-6632.2009.05347.x. PMID 20392215. S2CID 29853724.
• Tchernev VT, Mansfield TA, Giot L, Kumar AM, Nandabalan K, Li Y, Mishra VS, Detter JC, Rothberg JM, Wallace MR, Southwick FS, Kingsmore SF (januar 2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Molecular Medicine. 8 (1): 56–64. doi:10.1007/BF03402003. PMC 2039936. PMID 11984006.
• Spina R, Filocamo G, Iaccino E, Scicchitano S, Lupia M, Chiarella E, Mega T, Bernaudo F, Pelaggi D, Mesuraca M, Pazzaglia S, Semenkow S, Bar EE, Kool M, Pfister S, Bond HM, Eberhart CG, Steinkühler C, Morrone G (august 2013). "Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells". Oncotarget. 4 (8): 1280–92. doi:10.18632/oncotarget.1176. PMC 3787157. PMID 23907569.