ZNF516

Cinkoprstni protein 516 je protein koji je kod ljudi kodiran genom ZNF516.

ZNF516
Identifikatori
Aliasi	ZNF516
Vanjski ID-jevi	OMIM: 615114 MGI: 2443957 HomoloGene: 37122 GeneCards: ZNF516
Lokacija gena (čovjek) Hrom. Hromosom 18 (čovjek) Bend 18q23 Početak 76,357,682 bp Kraj 76,495,242 bp
Lokacija gena (miš) Hrom. Hromosom 18 (miš) Bend 18|18 E3 Početak 82,928,788 bp Kraj 83,023,439 bp
Ontologija gena Molekularna funkcija • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sequence-specific DNA binding • vezivanje sa DNK • GO:0001158 cis-regulatory region sequence-specific DNA binding • vezivanje iona metala • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • jedro Biološki proces • multicellular organism development • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • response to cold • adipose tissue development • GO:0009373 regulation of transcription, DNA-templated • transcription by RNA polymerase II • GO:0072468 Transdukcija signala • brown fat cell differentiation • transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • positive regulation of cold-induced thermogenesis Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	9658	329003
Ensembl	ENSG00000101493	ENSMUSG00000058881
UniProt	Q92618	Q7TSH3
RefSeq (mRNK)	NM_014643	NM_001177464 NM_183033
RefSeq (bjelančevina)	NP_055458	NP_001170935 NP_898854
Lokacija (UCSC)	Chr 18: 76.36 – 76.5 Mb	Chr 18: 82.93 – 83.02 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Dužina polipeptidnog lanca je 1.163 aminokiseline, sa molekulskom težinom od 124.289-

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MDRNREAEME		LRRGPSPTRA		GRGHEVDGDK		ATCHTCCICG		KSFPFQSSLS
QHMRKHTGEK		PYKCPYCDHR		ASQKGNLKIH		IRSHRTGTLI		QGHEPEAGEA
PLGEMRASEG		LDACASPTKS		ASACNRLLNG		ASQADGARVL		NGASQADSGR
VLLRSSKKGA		EGSACAPGEA		KAAVQCSFCK		SQFERKKDLE		LHVHQAHKPF
KCRLCSYATL		REESLLSHIE		RDHITAQGPG		SGEACVENGK		PELSPGEFPC
EVCGQAFSQT		WFLKAHMKKH		RGSFDHGCHI		CGRRFKEPWF		LKNHMKAHGP
KTGSKNRPKS		ELDPIATINN		VVQEEVIVAG		LSLYEVCAKC		GNLFTNLDSL
NAHNAIHRRV		EASRTRAPAE		EGAEGPSDTK		QFFLQCLNLR		PSAAGDSCPG
TQAGRRVAEL		DPVNSYQAWQ		LATRGKVAEP		AEYLKYGAWD		EALAGDVAFD
KDRREYVLVS		QEKRKREQDA		PAAQGPPRKR		ASGPGDPAPA		GHLDPRSAAR
PNRRAAATTG		QGKSSECFEC		GKIFRTYHQM		VLHSRVHRRA		RRERDSDGDR
AARARCGSLS		EGDSASQPSS		PGSACAAADS		PGSGLADEAA		EDSGEEGAPE
PAPGGQPRRC		CFSEEVTSTE		LSSGDQSHKM		GDNASERDTG		ESKAGIAASV
SILENSSRET		SRRQEQHRFS		MDLKMPAFHP		KQEVPVPGDG		VEFPSSTGAE
GQTGHPAEKL		SDLHNKEHSG		GGKRALAPDL		MPLDLSARST		RDDPSNKETA
SSLQAALVVH		PCPYCSHKTY		YPEVLWMHKR		IWHRVSCNSV		APPWIQPNGY
KSIRSNLVFL		SRSGRTGPPP		ALGGKECQPL		LLARFTRTQV		PGGMPGSKSG
SSPLGVVTKA		ASMPKNKESH		SGGPCALWAP		GPDGYRQTKP		CHGQEPHGAA
TQGPLAKPRQ		EASSKPVPAP		GGGGFSRSAT		PTPTVIARAG		AQPSANSKPV
EKFGVPPAGA		GFAPTNKHSA		PDSLKAKFSA		QPQGPPPAKG		EGGAPPLPPR
EPPSKAAQEL		RTLATCAAGS		RGDAALQAQP		GVAGAPPVLH		SIKQEPVAEG
HEKRLDILNI		FKTYIPKDFA		TLYQGWGVSG		PGLEHRGTLR		TQARPGEFVC
IECGKSFHQP		GHLRAHMRAH		SVVFESDGPR		GSEVHTTSAD		APKQGRDHSN
TGTVQTVPLR		KGT

Funkcija

Proteini cinkovog prsta vežu nukleinske kiseline i imaju važnu ulogu u različitim ćelijskim funkcijama, uključujući proliferacija ćelija, diferencijacija i apoptozu. Ovaj gen kodira protein cinkovog prsta i pripada porodici proteina cinka-prsta tipa Krüppel C2H2. Može biti uključen u proces transkripcije.

Dopunska literatura

• Shaffer JR, Feingold E, Wang X, Lee M, Tcuenco K, Weeks DE, Weyant RJ, Crout R, McNeil DW, Marazita ML (januar 2013). "GWAS of dental caries patterns in the permanent dentition". Journal of Dental Research. 92 (1): 38–44. doi:10.1177/0022034512463579. PMC 3521449. PMID 23064961.
• Shi Y, Sawada J, Sui G, Affar el B, Whetstine JR, Lan F, Ogawa H, Luke MP, Nakatani Y, Shi Y (april 2003). "Coordinated histone modifications mediated by a CtBP co-repressor complex". Nature. 422 (6933): 735–8. doi:10.1038/nature01550. PMID 12700765. S2CID 2670859.
• Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (oktobar 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
• Lee MG, Wynder C, Cooch N, Shiekhattar R (septembar 2005). "An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation". Nature. 437 (7057): 432–5. doi:10.1038/nature04021. PMID 16079794. S2CID 4396351.
• Yashin AI, Wu D, Arbeev KG, Ukraintseva SV (septembar 2010). "Joint influence of small-effect genetic variants on human longevity". Aging. 2 (9): 612–20. doi:10.18632/aging.100191. PMC 2984609. PMID 20834067.
• O'Brien RP, Phelan PJ, Conroy J, O'Kelly P, Green A, Keogan M, O'Neill D, Jennings S, Traynor C, Casey J, McCormack M, Conroy R, Chubb A, Ennis S, Shields DC, Cavalleri GL, Conlon PJ (2013). "A genome-wide association study of recipient genotype and medium-term kidney allograft function". Clinical Transplantation. 27 (3): 379–87. doi:10.1111/ctr.12093. PMID 23432519. S2CID 13087946.