ZNF398
Protein cinkovog prsta 398 jest protein koji je kod ljudi kodiran genom ZNF398.[5]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 642 aminokiseline, а molekulska težina 71.311 Da.[6]
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MAEAAPAPTS | EWDSECLTSL | QPLPLPTPPA | ANEAHLQTAA | ISLWTVVAAV | ||||
QAIERKVEIH | SRRLLHLEGR | TGTAEKKLAS | CEKTVTELGN | QLEGKWAVLG | ||||
TLLQEYGLLQ | RRLENLENLL | RNRNFWILRL | PPGIKGDIPK | VPVAFDDVSI | ||||
YFSTPEWEKL | EEWQKELYKN | IMKGNYESLI | SMDYAINQPD | VLSQIQPEGE | ||||
HNTEDQAGPE | ESEIPTDPSE | EPGISTSDIL | SWIKQEEEPQ | VGAPPESKES | ||||
DVYKSTYADE | ELVIKAEGLA | RSSLCPEVPV | PFSSPPAAAK | DAFSDVAFKS | ||||
QQSTSMTPFG | RPATDLPEAS | EGQVTFTQLG | SYPLPPPVGE | QVFSCHHCGK | ||||
NLSQDMLLTH | QCSHATEHPL | PCAQCPKHFT | PQADLSSTSQ | DHASETPPTC | ||||
PHCARTFTHP | SRLTYHLRVH | NSTERPFPCP | DCPKRFADQA | RLTSHRRAHA | ||||
SERPFRCAQC | GRSFSLKISL | LLHQRGHAQE | RPFSCPQCGI | DFNGHSALIR | ||||
HQMIHTGERP | YPCTDCSKSF | MRKEHLLNHR | RLHTGERPFS | CPHCGKSFIR | ||||
KHHLMKHQRI | HTGERPYPCS | YCGRSFRYKQ | TLKDHLRSGH | NGGCGGDSDP | ||||
SGQPPNPPGP | LITGLETSGL | GVNTEGLETN | QWYGEGSGGG | VL |
Funkcija
urediOvaj gen kodira člana porodice Kruppel proteina C2H2-tipa trankripcijskog faktora cinkovog prsta. Kodirani protein djeluje kao transkripcijski aktivator. Za ovaj gen su identificirane dvije varijante transkripta koje kodiraju različite izoforme. Opisane su i druge varijante transkripta, ali njihova puna sekvenca nije utvrđena.
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000197024 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062519 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Zinc finger protein 398". Pristupljeno 29. 2. 2016.
- ^ "UniProt, Q8TD17" (jezik: engleski). Pristupljeno 29. 9. 2021.
Dopunska literatura
uredi- Conroy AT, Sharma M, Holtz AE, Wu C, Sun Z, Weigel RJ (2002). "A novel zinc finger transcription factor with two isoforms that are differentially repressed by estrogen receptor-alpha". J. Biol. Chem. 277 (11): 9326–34. doi:10.1074/jbc.M107702200. PMID 11779858.