Protein cinkovog prsta 277 jest protein koji je kod ljudi kodiran genom ZNF277.[5][6][7][8]

ZNF277P
Identifikatori
AliasiZNF277
Vanjski ID-jeviOMIM: 605465 MGI: 1890393 HomoloGene: 11087 GeneCards: ZNF277
Lokacija gena (čovjek)
Hromosom 7 (čovjek)
Hrom.Hromosom 7 (čovjek)[1]
Hromosom 7 (čovjek)
Genomska lokacija za ZNF277P
Genomska lokacija za ZNF277P
Bend7q31.1Početak112,206,695 bp[1]
Kraj112,343,934 bp[1]
Lokacija gena (miš)
Hromosom 12 (miš)
Hrom.Hromosom 12 (miš)[2]
Hromosom 12 (miš)
Genomska lokacija za ZNF277P
Genomska lokacija za ZNF277P
Bend12|12 B1Početak40,365,045 bp[2]
Kraj40,495,901 bp[2]
Ontologija gena
Molekularna funkcija vezivanje sa DNK
vezivanje iona metala
nucleic acid binding
GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
Ćelijska komponenta jedro
Biološki proces regulation of cellular senescence
GO:0009373 regulation of transcription, DNA-templated
transcription, DNA-templated
cellular response to hydrogen peroxide
GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_021994

NM_172575
NM_178845

RefSeq (bjelančevina)

NP_068834

NP_766163
NP_849173

Lokacija (UCSC)Chr 7: 112.21 – 112.34 MbChr 12: 40.37 – 40.5 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

uredi

Dužina polipeptidnog lanca je 450 aminokiselina, а molekulska težina Da. 52 788[9]

1020304050
MAASKTQGAVARMQEDRDGSCSTVGGVGYGDSKDCILEPLSLPESPGGTT
TLEGSPSVPCIFCEEHFPVAEQDKLLKHMIIEHKIVIADVKLVADFQRYI
LYWRKRFTEQPITDFCSVIRINSTAPFEEQENYFLLCDVLPEDRILREEL
QKQRLREILEQQQQERNDTNFHGVCMFCNEEFLGNRSVILNHMAREHAFN
IGLPDNIVNCNEFLCTLQKKLDNLQCLYCEKTFRDKNTLKDHMRKKQHRK
INPKNREYDRFYVINYLELGKSWEEVQLEDDRELLDHQEDDWSDWEEHPA
SAVCLFCEKQAETIEKLYVHMEDAHEFDLLKIKSELGLNFYQQVKLVNFI
RRQVHQCRCYGCHVKFKSKADLRTHMEETKHTSLLPDRKTWDQLEYYFPT
YENDTLLCTLSDSESDLTAQEQNENVPIISEDTSKLYALKQSSILNQLLL

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198839 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055917 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Liang H, Guo W, Nagarajan L (Aug 2000). "Chromosomal mapping and genomic organization of an evolutionarily conserved zinc finger gene ZNF277". Genomics. 66 (2): 226–8. doi:10.1006/geno.2000.6198. PMID 10860669.
  6. ^ Liang H, Castro PD, Ma J, Nagarajan L (Oct 2005). "Finer delineation and transcript map of the 7q31 locus deleted in myeloid neoplasms". Cancer Genet Cytogenet. 162 (2): 151–9. doi:10.1016/j.cancergencyto.2005.03.019. PMID 16213364.
  7. ^ Hahn Y, Lee B (Feb 2006). "Human-specific nonsense mutations identified by genome sequence comparisons". Hum Genet. 119 (1–2): 169–78. doi:10.1007/s00439-005-0125-6. PMID 16395595. S2CID 21059468.
  8. ^ "Entrez Gene: ZNF277P zinc finger protein 277 pseudogene".
  9. ^ "UniProt, Q9NRM2" (jezik: engleski). Pristupljeno 29. 9. 2021.

Dopunska literatura

uredi