ZNF274

Protein 274 cinkovog prsta je protein koji je kod ljudi kodiran genom ZNF274.

ZNF274
Identifikatori
Aliasi	ZNF274
Vanjski ID-jevi	OMIM: 605467 MGI: 2176229 HomoloGene: 129707 GeneCards: ZNF274
Lokacija gena (čovjek) Hrom. Hromosom 19 (čovjek) Bend 19q13.43 Početak 58,183,029 bp Kraj 58,213,562 bp
Lokacija gena (miš) Hrom. Hromosom 13 (miš) Bend 13|13 B3 Početak 65,426,628 bp Kraj 65,452,035 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sequence-specific DNA binding • vezivanje sa DNK • GO:0001948, GO:0016582 vezivanje za proteine • GO:0001106 transcription corepressor activity • vezivanje iona metala • nucleic acid binding • chromatin binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • citoplazma • Jedarce • intracellular anatomical structure • jedro Biološki proces • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • regulation of histone H3-K9 trimethylation • negative regulation of nucleic acid-templated transcription • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	10782	170936
Ensembl	ENSG00000171606	ENSMUSG00000021514
UniProt	Q96GC6	Q921B4
RefSeq (mRNK)	NM_001278734 NM_001278735 NM_016324 NM_016325 NM_133502	NM_178364
RefSeq (bjelančevina)	NP_001265663 NP_057408 NP_057409 NP_598009	n/a
Lokacija (UCSC)	Chr 19: 58.18 – 58.21 Mb	Chr 13: 65.43 – 65.45 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Ovaj gen kodira protein cinkovog prsta koji sadrži pet domena cinkovog prsta tipa C2H2, jedan ili dva domena polja A (KRAB A) povezane s Kruppelom i domen bogat leucinom. Za kodirani protein se pretpostavlja da je transkripcijski represor. Lokalizira se pretežno na jedarcetu. Postoje alternativno prerašene varijante transkripta koje kodiraju različite izoforme. Ove varijante koriste alternativne poliadenilirajuće signale.

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MASRLPTAWS		CEPVTFEDVT		LGFTPEEWGL		LDLKQKSLYR		EVMLENYRNL
VSVEHQLSKP		DVVSQLEEAE		DFWPVERGIP		QDTIPEYPEL		QLDPKLDPLP
AESPLMNIEV		VEVLTLNQEV		AGPRNAQIQA		LYAEDGSLSA		DAPSEQVQQQ
GKHPGDPEAA		RQRFRQFRYK		DMTGPREALD		QLRELCHQWL		QPKARSKEQI
LELLVLEQFL		GALPVKLRTW		VESQHPENCQ		EVVALVEGVT		WMSEEEVLPA
GQPAEGTTCC		LEVTAQQEEK		QEDAAICPVT		VLPEEPVTFQ		DVAVDFSREE
WGLLGPTQRT		EYRDVMLETF		GHLVSVGWET		TLENKELAPN		SDIPEEEPAP
SLKVQESSRD		CALSSTLEDT		LQGGVQEVQD		TVLKQMESAQ		EKDLPQKKHF
DNRESQANSG		ALDTNQVSLQ		KIDNPESQAN		SGALDTNQVL		LHKIPPRKRL
RKRDSQVKSM		KHNSRVKIHQ		KSCERQKAKE		GNGCRKTFSR		STKQITFIRI
HKGSQVCRCS		ECGKIFRNPR		YFSVHKKIHT		GERPYVCQDC		GKGFVQSSSL
TQHQRVHSGE		RPFECQECGR		TFNDRSAISQ		HLRTHTGAKP		YKCQDCGKAF
RQSSHLIRHQ		RTHTGERPYA		CNKCGKAFTQ		SSHLIGHQRT		HNRTKRKKKQ
PTS

Dopunska literatura

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Petroni D, Bartolini E, Chiaramonte R, et al. (1999). "Computer sequence analysis of human highly conserved zinc finger modules". DNA Seq. 9 (3): 163–9. doi:10.3109/10425179809072191. PMID 10520746.
• Casademunt E, Carter BD, Benzel I, et al. (2000). "The zinc finger protein NRIF interacts with the neurotrophin receptor p75(NTR) and participates in programmed cell death". EMBO J. 18 (21): 6050–61. doi:10.1093/emboj/18.21.6050. PMC 1171670. PMID 10545116.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Sripathy SP, Stevens J, Schultz DC (2007). "The KAP1 Corepressor Functions To Coordinate the Assembly of De Novo HP1-Demarcated Microenvironments of Heterochromatin Required for KRAB Zinc Finger Protein-Mediated Transcriptional Repression". Mol. Cell. Biol. 26 (22): 8623–38. doi:10.1128/MCB.00487-06. PMC 1636786. PMID 16954381.

Vanjski linkovi

• ZNF274 protein, human na US National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook ZNF274