ZNF266

Protein 226 cinkovog prsta je protein koji je kod ljudi kodiran genom ZNF226.

ZNF266
Identifikatori
Aliasi	ZNF266
Vanjski ID-jevi	OMIM: 604751 MGI: 1924769 HomoloGene: 105676 GeneCards: ZNF266
Lokacija gena (čovjek) Hrom. Hromosom 19 (čovjek) Bend 19p13.2 Početak 9,412,461 bp Kraj 9,435,571 bp
Lokacija gena (miš) Hrom. Hromosom 9 (miš) Bend 9|9 A3 Početak 20,406,364 bp Kraj 20,432,713 bp
Ontologija gena Molekularna funkcija • vezivanje sa DNK • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje iona metala • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • intracellular anatomical structure • jedro Biološki proces • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	10781	77519
Ensembl	ENSG00000174652	ENSMUSG00000060510
UniProt	Q14584	n/a
RefSeq (mRNK)	NM_001271314 NM_006631 NM_198058	NM_001082485 NM_001135019
RefSeq (bjelančevina)	NP_001258243 NP_006622 NP_001357303 NP_001357304 NP_001357305 NP_001357306 NP_001357307 NP_001357308 NP_001357309 NP_001357310 NP_001357311 NP_001357312 NP_001357313 NP_001357314 NP_001357315 NP_001357316 NP_001357317 NP_001357318 NP_001357319 NP_001357320 NP_001357321 NP_001357322 NP_001357323 NP_001357324 NP_001357325 NP_001357326 NP_001357327 NP_001357328 NP_001357329	n/a
Lokacija (UCSC)	Chr 19: 9.41 – 9.44 Mb	Chr 9: 20.41 – 20.43 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MLENYKNLAT		VGYQLFKPSL		ISWLEQEESR		TVQRGDFQAS		EWKVQLKTKE
LALQQDVLGE		PTSSGIQMIG		SHNGGEVSDV		KQCGDVSSEH		SCLKTHVRTQ
NSENTFECYL		YGVDFLTLHK		KTSTGEQRSV		FSQCGKAFSL		NPDVVCQRTC
TGEKAFDCSD		SGKSFINHSH		LQGHLRTHNG		ESLHEWKECG		RGFIHSTDLA
VRIQTHRSEK		PYKCKECGKG		FRYSAYLNIH		MGTHTGDNPY		ECKECGKAFT
RSCQLTQHRK		THTGEKPYKC		KDCGRAFTVS		SCLSQHMKIH		VGEKPYECKE
CGIAFTRSSQ		LTEHLKTHTA		KDPFECKICG		KSFRNSSCLS		DHFRIHTGIK
PYKCKDCGKA		FTQNSDLTKH		ARTHSGERPY		ECKECGKAFA		RSSRLSEHTR
THTGEKPFEC		VKCGKAFAIS		SNLSGHLRIH		TGEKPFECLE		CGKAFTHSSS
LNNHMRTHSA		KKPFTCMECG		KAFKFPTCVN		LHMRIHTGEK		PYKCKQCGKS
FSYSNSFQLH		ERTHTGEKPY		ECKECGKAFS		SSSSFRNHER		RHADERLSA

Funkcija

Ovaj gen kodira protein koji sadrži mnoge tandemske motive cinkovog prsta. Cinkovi prsti su domeni koje vežu proteine ili nukleinske kiseline i mogu biti uključeni u razne funkcije, uključujući regulaciju transkripcije. Ovaj gen nalazi se u skupu sličnih gena koji kodiraju proteine cinkovih prstiju na hromosomu 19. [[alternativna prerada RAKlAlternativna prerada rezultira višestrukim varijantama transkripta ovog gena.

Interakcije

Pokazalo se da proteini cinkovog prsta ulaze u interakciju s nukleinskim kiselinama i imaju različite funkcije. Domen cinkovog prsta je konzervirani motiv aminokiselinske sekvence koji sadrži po dva posebno postavljena cisteina i histidina, koji su uključeni u koordinaciju cinka. Proteini povezani sa Kruppelom čine jednu porodicu proteina cinkovih prstiju.

Dopunska literatura

• Liu X, Jin EZ, Zhi JX, Li XQ (2011). "Identification of HZF1 as a novel target gene of the MEF2 transcription factor". Molecular Medicine Reports. 4 (3): 465–9. doi:10.3892/mmr.2011.465. PMID 21468593.
• Abrink M, Aveskogh M, Hellman L (Feb 1995). "Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937". DNA and Cell Biology. 14 (2): 125–36. doi:10.1089/dna.1995.14.125. PMID 7865130.
• Peng H, Du ZW, Zhang JW (Jun 2006). "Identification and characterization of a novel zinc finger protein (HZF1) gene and its function in erythroid and megakaryocytic differentiation of K562 cells". Leukemia. 20 (6): 1109–16. doi:10.1038/sj.leu.2404212. PMID 16628192.
• Li XB, Chen J, Deng MJ, Wang F, Du ZW, Zhang JW (2011). "Zinc finger protein HZF1 promotes K562 cell proliferation by interacting with and inhibiting INCA1". Molecular Medicine Reports. 4 (6): 1131–7. doi:10.3892/mmr.2011.564. PMID 21874239.
• Deng MJ, Li XB, Peng H, Zhang JW (Feb 2010). "Identification of the trans-activation domain and the nuclear location signals of human zinc finger protein HZF1 (ZNF16)". Molecular Biotechnology. 44 (2): 83–9. doi:10.1007/s12033-009-9210-8. PMID 19763908. S2CID 3470718.
• Gamsjaeger R, Liew CK, Loughlin FE, Crossley M, Mackay JP (Feb 2007). "Sticky fingers: zinc-fingers as protein-recognition motifs". Trends in Biochemical Sciences. 32 (2): 63–70. doi:10.1016/j.tibs.2006.12.007. PMID 17210253.
• Fransen K, Visschedijk MC, van Sommeren S, Fu JY, Franke L, Festen EA, Stokkers PC, van Bodegraven AA, Crusius JB, Hommes DW, Zanen P, de Jong DJ, Wijmenga C, van Diemen CC, Weersma RK (Sep 2010). "Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease". Human Molecular Genetics. 19 (17): 3482–8. doi:10.1093/hmg/ddq264. PMID 20601676.

Vanjski linkovi