Protein cinkovog prsta sa KRAB i SCAN domenom 5 jest protein koji je kod ljudi kodiran genom ZKSCAN5.[5][6]

ZKSCAN5
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

2EM5, 2EMM, 2EMZ, 2EN3, 2EOM, 2EON, 2EOO, 2YSO, 2YTG

Identifikatori
AliasiZKSCAN5
Vanjski ID-jeviOMIM: 611272 MGI: 107533 HomoloGene: 8734 GeneCards: ZKSCAN5
Lokacija gena (čovjek)
Hromosom 7 (čovjek)
Hrom.Hromosom 7 (čovjek)[1]
Hromosom 7 (čovjek)
Genomska lokacija za ZKSCAN5
Genomska lokacija za ZKSCAN5
Bend7q22.1Početak99,504,662 bp[1]
Kraj99,534,700 bp[1]
Lokacija gena (miš)
Hromosom 5 (miš)
Hrom.Hromosom 5 (miš)[2]
Hromosom 5 (miš)
Genomska lokacija za ZKSCAN5
Genomska lokacija za ZKSCAN5
Bend5|5 G2Početak145,141,372 bp[2]
Kraj145,158,560 bp[2]
Obrazac RNK ekspresije


Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija vezivanje sa DNK
vezivanje iona cinka
GO:0001948, GO:0016582 vezivanje za proteine
vezivanje iona metala
nucleic acid binding
GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
Ćelijska komponenta intracellular anatomical structure
jedro
Biološki proces transcription, DNA-templated
GO:0009373 regulation of transcription, DNA-templated
GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_014569
NM_145102
NM_001318082
NM_001318083
NM_001318084

NM_001167944
NM_016683
NM_001359187
NM_001359188
NM_001359189

NM_001359190
NM_001359191
NM_001359192

RefSeq (bjelančevina)

NP_001305011
NP_001305012
NP_001305013
NP_055384
NP_659570

NP_001161416
NP_057892
NP_001346116
NP_001346117
NP_001346118

NP_001346119
NP_001346120
NP_001346121

Lokacija (UCSC)Chr 7: 99.5 – 99.53 MbChr 5: 145.14 – 145.16 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

uredi

Dužina polipeptidnog lanca je 839 aminokiselina, а molekulska težina 969.03 Da.[7]

1020304050
MIMTESREVIDLDPPAETSQEQEDLFIVKVEEEDCTWMQEYNPPTFETFY
QRFRHFQYHEASGPREALSQLRVLCCEWLRPELHTKEQILELLVLEQFLT
ILPEEFQPWVREHHPESGEEAVAVIENIQRELEERRQQIVACPDVLPRKM
ATPGAVQESCSPHPLTVDTQPEQAPQKPRLLEENALPVLQVPSLPLKDSQ
ELTASLLSTGSQKLVKIEEVADVAVSFILEEWGHLDQSQKSLYRDDRKEN
YGSITSMGYESRDNMELIVKQISDDSESHWVAPEHTERSVPQDPDFAEVS
DLKGMVQRWQVNPTVGKSRQNPSQKRDLDAITDISPKQSTHGERGHRCSD
CGKFFLQASNFIQHRRIHTGEKPFKCGECGKSYNQRVHLTQHQRVHTGEK
PYKCQVCGKAFRVSSHLVQHHSVHSGERPYGCNECGKNFGRHSHLIEHLK
RHFREKSQRCSDKRSKNTKLSVKKKISEYSEADMELSGKTQRNVSQVQDF
GEGCEFQGKLDRKQGIPMKEILGQPSSKRMNYSEVPYVHKKSSTGERPHK
CNECGKSFIQSAHLIQHQRIHTGEKPFRCEECGKSYNQRVHLTQHQRVHT
GEKPYTCPLCGKAFRVRSHLVQHQSVHSGERPFKCNECGKGFGRRSHLAG
HLRLHSREKSHQCRECGEIFFQYVSLIEHQVLHMGQKNEKNGICEEAYSW
NLTVIEDKKIELQEQPYQCDICGKAFGYSSDLIQHYRTHTAEKPYQCDIC
RENVGQCSHTKQHQKIYSSTKSHQCHECGRGFTLKSHLNQHQRIHTGEKP
FQCKECGMNFSWSCSLFKHLRSHERTDPINTLSVEGSLL

Funkcija

uredi

Ovaj gen kodira protein cinkovog prsta iz porodice Krüppel. Protein sadrži SCAN kutiju i domen KRAB. Sličan protein kod miševa različito se eksprimira u spermatogenezi. Opisane su dvije varijante transkripta alternativne prerade koje se razlikuju samo u pet osnovnih neprevedenih regija (5' UTR). Pronađene su dodatne varijante, ali pune dužine njihove sekvence u nisu utvrđene.[6]

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196652 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055991 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dreyer SD, Zheng Q, Zabel B, Winterpacht A, Lee B (Feb 2000). "Isolation, characterization, and mapping of a zinc finger gene, ZFP95, containing both a SCAN box and an alternatively spliced KRAB A domain". Genomics. 62 (1): 119–22. doi:10.1006/geno.1999.5981. PMID 10585779.
  6. ^ a b "Entrez Gene: ZKSCAN5 zinc finger with KRAB and SCAN domains 5".
  7. ^ "UniProt, Q9Y2L8" (jezik: engleski). Pristupljeno 29. 9. 2021.

Dopunska literatura

uredi