ZKSCAN5
Protein cinkovog prsta sa KRAB i SCAN domenom 5 jest protein koji je kod ljudi kodiran genom ZKSCAN5.[5][6]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 839 aminokiselina, а molekulska težina 969.03 Da.[7]
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MIMTESREVI | DLDPPAETSQ | EQEDLFIVKV | EEEDCTWMQE | YNPPTFETFY | ||||
QRFRHFQYHE | ASGPREALSQ | LRVLCCEWLR | PELHTKEQIL | ELLVLEQFLT | ||||
ILPEEFQPWV | REHHPESGEE | AVAVIENIQR | ELEERRQQIV | ACPDVLPRKM | ||||
ATPGAVQESC | SPHPLTVDTQ | PEQAPQKPRL | LEENALPVLQ | VPSLPLKDSQ | ||||
ELTASLLSTG | SQKLVKIEEV | ADVAVSFILE | EWGHLDQSQK | SLYRDDRKEN | ||||
YGSITSMGYE | SRDNMELIVK | QISDDSESHW | VAPEHTERSV | PQDPDFAEVS | ||||
DLKGMVQRWQ | VNPTVGKSRQ | NPSQKRDLDA | ITDISPKQST | HGERGHRCSD | ||||
CGKFFLQASN | FIQHRRIHTG | EKPFKCGECG | KSYNQRVHLT | QHQRVHTGEK | ||||
PYKCQVCGKA | FRVSSHLVQH | HSVHSGERPY | GCNECGKNFG | RHSHLIEHLK | ||||
RHFREKSQRC | SDKRSKNTKL | SVKKKISEYS | EADMELSGKT | QRNVSQVQDF | ||||
GEGCEFQGKL | DRKQGIPMKE | ILGQPSSKRM | NYSEVPYVHK | KSSTGERPHK | ||||
CNECGKSFIQ | SAHLIQHQRI | HTGEKPFRCE | ECGKSYNQRV | HLTQHQRVHT | ||||
GEKPYTCPLC | GKAFRVRSHL | VQHQSVHSGE | RPFKCNECGK | GFGRRSHLAG | ||||
HLRLHSREKS | HQCRECGEIF | FQYVSLIEHQ | VLHMGQKNEK | NGICEEAYSW | ||||
NLTVIEDKKI | ELQEQPYQCD | ICGKAFGYSS | DLIQHYRTHT | AEKPYQCDIC | ||||
RENVGQCSHT | KQHQKIYSST | KSHQCHECGR | GFTLKSHLNQ | HQRIHTGEKP | ||||
FQCKECGMNF | SWSCSLFKHL | RSHERTDPIN | TLSVEGSLL |
Funkcija
urediOvaj gen kodira protein cinkovog prsta iz porodice Krüppel. Protein sadrži SCAN kutiju i domen KRAB. Sličan protein kod miševa različito se eksprimira u spermatogenezi. Opisane su dvije varijante transkripta alternativne prerade koje se razlikuju samo u pet osnovnih neprevedenih regija (5' UTR). Pronađene su dodatne varijante, ali pune dužine njihove sekvence u nisu utvrđene.[6]
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000196652 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055991 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Dreyer SD, Zheng Q, Zabel B, Winterpacht A, Lee B (Feb 2000). "Isolation, characterization, and mapping of a zinc finger gene, ZFP95, containing both a SCAN box and an alternatively spliced KRAB A domain". Genomics. 62 (1): 119–22. doi:10.1006/geno.1999.5981. PMID 10585779.
- ^ a b "Entrez Gene: ZKSCAN5 zinc finger with KRAB and SCAN domains 5".
- ^ "UniProt, Q9Y2L8" (jezik: engleski). Pristupljeno 29. 9. 2021.
Dopunska literatura
uredi- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Thompson EE, Kuttab-Boulos H, Yang L, et al. (2006). "Sequence diversity and haplotype structure at the human CYP3A cluster". Pharmacogenomics J. 6 (2): 105–14. doi:10.1038/sj.tpj.6500347. PMID 16314882.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.