ZBED3

Protein 3 cinkovog prsta sa BED domenom, poznat i kao aksin-interaktivni protein je protein koji je kod ljudi kodiran genom ZBED3.

ZBED3
Identifikatori
Aliasi	ZBED3
Vanjski ID-jevi	OMIM: 615250 MGI: 1919364 HomoloGene: 12442 GeneCards: ZBED3
Lokacija gena (čovjek) Hrom. Hromosom 5 (čovjek) Bend 5q13.3 Početak 77,072,072 bp Kraj 77,087,285 bp
Lokacija gena (miš) Hrom. Hromosom 13 (miš) Bend 13|13 D1 Početak 95,460,120 bp Kraj 95,474,349 bp
Ontologija gena Molekularna funkcija • vezivanje sa DNK • vezivanje iona metala • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • citoplazma • membrana • citosol Biološki proces • positive regulation of canonical Wnt signaling pathway • GO:0033128 negative regulation of protein phosphorylation • protein stabilization • Wnt-signalni put • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	84327	72114
Ensembl	ENSG00000132846	ENSMUSG00000041995
UniProt	Q96IU2	Q9D0L1
RefSeq (mRNK)	NM_032367 NM_001329564	NM_028106 NM_001302538 NM_001302539
RefSeq (bjelančevina)	NP_001316493 NP_115743	NP_001289467 NP_001289468 NP_082382
Lokacija (UCSC)	Chr 5: 77.07 – 77.09 Mb	Chr 13: 95.46 – 95.47 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 234 aminokiseline, a molekulska težina 25.132 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MRSGEPACTM		DQARGLDDAA		ARGGQCPGLG		PAPTPTPPGR		LGAPYSEAWG
YFHLAPGRPG		HPSGHWATCR		LCGEQVGRGP		GFHAGTSALW		RHLRSAHRRE
LESSGAGSSP		PAAPCPPPPG		PAAAPEGDWA		RLLEQMGALA		VRGSRREREL
ERRELAVEQG		ERALERRRRA		LQEEERAAAQ		ARRELQAERE		ALQARLRDVS
RREGALGWAP		AAPPPLKDDP		EGDRDGCVIT		KVLL

Dopunska literatura

• Hayward A, Ghazal A, Andersson G, Andersson L, Jern P (2013). Robinson-Rechavi M (ured.). "ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions". PLOS ONE. 8 (3): e59940. Bibcode:2013PLoSO...859940H. doi:10.1371/journal.pone.0059940. PMC 3606216. PMID 23533661.
• de Miguel-Yanes JM, Shrader P, Pencina MJ, Fox CS, Manning AK, Grant RW, Dupuis J, Florez JC, D'Agostino RB, Cupples LA, Meigs JB (Jan 2011). "Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms" (PDF). Diabetes Care. 34 (1): 121–5. doi:10.2337/dc10-1265. PMC 3005447. PMID 20889853.
• Chen T, Li M, Ding Y, Zhang LS, Xi Y, Pan WJ, Tao DL, Wang JY, Li L (Mar 2009). "Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling". The Journal of Biological Chemistry. 284 (11): 6683–9. doi:10.1074/jbc.M807753200. PMC 2652294. PMID 19141611.
• Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, et al. (Jul 2010). "Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis". Nature Genetics. 42 (7): 579–89. doi:10.1038/ng.609. PMC 3080658. PMID 20581827. CS1 održavanje: nepreporučeni parametar (link)