XIRP2
Protein ksin aktina sa ponavljanjem 2 jest protein koji je kod ljudi kodiran genom XIRP2 sa hromosoma 2.[5][6][7][8]
Amiokiselininska sekvenca
urediDužina polipeptidnog lanca je 3 374 aminokiseline, a molekulska težina 382.300 Da.[9]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MSPESGHSRI | FEATAGPNKP | ESGFAEDSAA | RGEGVSDLHE | VVSLKERMAR | ||||
| YQAAVSRGDC | RSFSANMMEE | SEMCAVPGGL | AKVKKQFEDE | ITSSRNTFAQ | ||||
| YQYQHQNRSE | QEAIHSSQVG | TSRSSQEMAR | NEQEGSKVQK | IDVHGTEMVS | ||||
| HLEKHTEEVN | QASQFHQYVQ | ETVIDTPEDE | EIPKVSTKLL | KEQFEKSAQE | ||||
| KILYSDKEMT | TPAKQIKTES | EYEETFKPSS | VVSTSSTSCV | STSQRKETST | ||||
| TRYSDHSVTS | STLAQINATS | SGMTEEFPPP | PPDVLQTSVD | VTAFSQSPEL | ||||
| PSPPRRLPVP | KDVYSKQRNL | YELNRLYKHI | HPELRKNLEK | DYISEVSEIV | ||||
| SSQMNSGSSV | SADVQQARYV | FENTNDSSQK | DLNSEREYLE | WDEILKGEVQ | ||||
| SIRWIFENQP | LDSINNGSPD | EGDISRGIAD | QEIIAGGDVK | YTTWMFETQP | ||||
| IDTLGAYSSD | TVENAEKIPE | LARGDVCTAR | WMFETRPLDS | MNKMHQSQEE | ||||
| SAVTISKDIT | GGDVKTVRYM | FETQHLDQLG | QLHSVDEVHL | LQLRSELKEI | ||||
| KGNVKRSIKC | FETQPLYVIR | DGSGQMLEIK | TVHREDVEKG | DVRTARWMFE | ||||
| TQPLDTINKD | ITEIKVVRGI | SMEENVKGGV | SKAKWLFETQ | PLEKIKESEE | ||||
| VIIEKEKIIG | TDVSRKCWMF | ETQPLDILKE | VPDADSLQRE | EIIGGDVQTT | ||||
| KHLFETLPIE | ALKDSPDIGK | LQKITASEEE | KGDVRHQKWI | FETQPLEDIR | ||||
| KDKKEYTRTV | KLEEVDRGDV | KNYTHIFESN | NLIKFDASHK | IEVEGVTRGA | ||||
| VELNKSLFET | TPLYAIQDPL | GKYHQVKTVQ | QEEIVRGDVR | SCRWLFETRP | ||||
| IDQFDESIHK | FQIIRGISAQ | EIQTGNVKSA | KWLFETQPLD | SIKYFSDVEE | ||||
| TESKTEQTRD | IVKGDVKTCK | WLFETQPMES | LYEKVSLMTS | SEEIHKGDVK | ||||
| TCTWLFETQP | LDTIKDDSET | AVKLQTVKQE | EIQGGDVRTA | CFLFETENLD | ||||
| SIQGEEVKEI | KPVEMDIQAG | DVSSMRYKFE | NQSLDSISSS | SEEVLKKIKT | ||||
| LKTEDIQKGN | VLNCRWLFEN | QPIDKIKESQ | EGDECVKTVT | DIQGGDVRKG | ||||
| CFIFETFSLD | EIKEESDYIS | TKKTITEEVI | QGDVKSYRML | FETQPLYAIQ | ||||
| DREGSYHEVT | TVKKEEVIHG | DVRGTRWLFE | TKPLDSINKS | ETVYVIKSVT | ||||
| QEDIQKGDVS | SVRYRFETQP | LDQISEESHN | IMPSIDHIQG | GNVKTSRQFF | ||||
| ESENFDKNNY | IRTVSVNEIQ | KGNVKTSTWL | FETHTMDELR | GEGLEYENIK | ||||
| TVTQEDVQKG | DVKQAVWLFE | NRTFDSIMEA | HKGITKMTKE | EIPPSDVKTT | ||||
| TWLFETTPLH | EFNETRVEKI | EIIGKSIKET | LEDLYSQKVI | QAPGIIIEAD | ||||
| EIGDVRMAKY | KLMNQASPEI | QKEEIIRADL | RNIMVNLLSK | RDCTEREILI | ||||
| SEEEKGNVNL | TKTQLLNRST | EFHAEKEEIV | KGDVQQAIKN | LFSEERSVKK | ||||
| GILIQEDEKG | DINMTIYCLL | HENDGDTIER | EEVIGGDVKR | TIHNLLSSTS | ||||
| NNKISERAKI | DASERGNVQF | FTTCIEAGAL | DYLKQLHTES | NETLTAKKQE | ||||
| GEKEIIGGDV | EGTKLLLKKR | QSLVERTVSE | TDIIPGDVHN | TVKVFMTEPQ | ||||
| STFGKIPKEE | IIKGDLTSTL | NSLSQAVNQK | TVTKTEEIIK | GNMLATLKSL | ||||
| KESSHRWKES | KQPDAIPGDI | EKAIECLEKA | TNTKTEILKK | ELLKDDLETS | ||||
| LRSLKEAQRS | FKEVHKEGVI | KKDAKAVMAG | SSGEQKTDIH | QVAVQRNKNS | ||||
| LLQPKPGPFE | PAAKWQGGAD | TLSQTMGKSC | HGNLVEERTE | VNLPKAPKGT | ||||
| VKIVIDREQN | NDALEKSLRR | LSNSHHKSNV | LESGDKTGVW | TDTTGEQHLR | ||||
| DEYMSRQLTS | TVSVKNNLTT | KESDRAVREL | KKDDVFNSIQ | SAGKTVGKQQ | ||||
| TYELRNDHQK | MEGFHIKSPK | KTKNIKILTD | TQSSKPSPTQ | HPVSMPVGGT | ||||
| YDLSGDFQKQ | TLLKQETKYS | NKDIKKKNIN | LQPMWQLLPV | EQDTSNVTEM | ||||
| KVSEKSHNTF | KATNKKRETD | VHLKSQDFLM | KTNTSTGLKM | AMERSLNPIN | ||||
| FNPENNVKES | ECPLPPPSPP | PPPPSNASSE | IEFPLPPPPP | LMMFPEKNGF | ||||
| LPSLSTEKIK | AEFESFPGLP | LPPPPVDEKS | ERESSSMFLP | PPPPPTPSQK | ||||
| PAHLLSSSAP | EKHSGDFMQQ | YSQKEASNSQ | NSQAKIITGK | TGVLPPPTLP | ||||
| KPKLPKHIKD | NKNDFSPKVE | LATSLSDMEC | KITTSKDQKK | VMVMTSSEHT | ||||
| ETKQNVISKS | LDERKQLSID | SANCLSHTVP | GTSAPRKKQI | APLIKSHSFP | ||||
| ESSGQQNPKP | YMRKFKTPLM | IAEEKYRQQK | EEIEKQKQES | SYYNIVKTQS | ||||
| QNQHITEVEK | EMPLQKTNEE | VSLSGIDSEC | TVVQPSPGSQ | SNARILGVCS | ||||
| DNQLSTTSPE | TVAAKRLHHV | LAASEDKDKM | KKEVLQSSRD | IMQSKSACEI | ||||
| KQSHQECSTQ | QTQQKKYLEQ | LHLPQSKPIS | PNFKVKTIKL | PTLDHTLNET | ||||
| DHSYESHKQQ | SEIDVQTFTK | KQYLKTKKTE | ASTECSHKQS | LAERHYQLPK | ||||
| KEKRVTVQLP | TESIQKNQED | KLKMVPRKQR | EFSGSDRGKL | PGSEEKNQGP | ||||
| SMIGRKEERL | ITERKHEHLK | NKSAPKVVKQ | KVIDAHLDSQ | TQNFQQTQIQ | ||||
| TAESKAEHKK | LPQPYNSLQE | EKCLEVKGIQ | EKQVFSNTKD | SKQEITQNKS | ||||
| FFSSVKESQR | DDGKGALNIV | EFLRKREELQ | QILSRVKQFE | AEPNKSGLKT | ||||
| FQTLLNTIPG | WLISEDKREY | AVHIAMENNL | EKVKEEITHI | KTQAEDMLVS | ||||
| YENIIQTAMM | SSKTGKPGNK | PTSLDETSSK | VSNVHVSNNK | NSEQKENKIA | ||||
| KEKTVQHQVA | AHHEATVRSH | VKTHQEIKLD | DSNIPPPSLK | TRPPSPTFIT | ||||
| IESTARRTEN | PTKNELSQSP | KKDSYVEPPP | RRPMSQKSEI | HRANTSPSPP | ||||
| RSRSEQLVRL | KDTTAKLSKG | AIPCPAATPV | PIVEKRSEII | MSPATLRRQI | ||||
| KIETRGRDSP | PTITIPVNIN | HAASGSFRES | VDAQEEIRKV | EKRATYVHKD | ||||
| GLNSTDHMVP | DTESYDAVEI | IRKVAVPPRL | SEHTQRYEAA | NRTVQMAENF | ||||
| VNDPENEINR | WFREFEHGPV | SEAKSNRRVY | AKGETNHNIQ | QESRTFCKEE | ||||
| FGLTSLGNTS | FTDFSCKHPR | ELREKIPVKQ | PRICSETRSL | SEHFSGMDAF | ||||
| ESQIVESKMK | TSSSHSSEAG | KSGCDFKHAP | PTYEDVIAGH | ILDISDSPKE | ||||
| VRKNFQKTWQ | ESGRVFKGLG | YATADASATE | MRTTFQEESA | FISEAAAPRQ | ||||
| GNMYTLSKDS | LSNGVPSGRQ | AEFS |
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000163092 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027022 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Huang HT, Brand OM, Mathew M, Ignatiou C, Ewen EP, McCalmon SA, Naya FJ (Dec 2006). "Myomaxin is a novel transcriptional target of MEF2A that encodes a Xin-related alpha-actinin-interacting protein". J Biol Chem. 281 (51): 39370–9. doi:10.1074/jbc.M603244200. PMID 17046827.
- ^ Sinn HW, Balsamo J, Lilien J, Lin JJ (Aug 2002). "Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development". Dev Dyn. 225 (1): 1–13. doi:10.1002/dvdy.10131. PMID 12203715. S2CID 23393425.
- ^ Pacholsky D, Vakeel P, Himmel M, Lowe T, Stradal T, Rottner K, Furst DO, van der Ven PF (Oct 2004). "Xin repeats define a novel actin-binding motif". J Cell Sci. 117 (Pt 22): 5257–68. doi:10.1242/jcs.01406. PMID 15454575.
- ^ "Entrez Gene: CMYA3 cardiomyopathy associated 3".
- ^ "UniProt, A4UGR9" (jezik: engleski). Pristupljeno 17. 11. 2021.
Dopunska literatura
uredi- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Blasi F, Bacchelli E, Carone S, et al. (2006). "SLC25A12 and CMYA3 gene variants are not associated with autism in the IMGSAC multiplex family sample". Eur. J. Hum. Genet. 14 (1): 123–6. doi:10.1038/sj.ejhg.5201444. PMID 16205742.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Pan PW, Li K, Tuggle CK, et al. (2004). "Sequencing, tissue distribution and physical mapping of the porcine homologue of cardiomyopathy associated 3 (CMYA3)". Anim. Genet. 34 (6): 473–4. doi:10.1046/j.0268-9146.2003.01059.x. PMID 14687087.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.