VNN1

Panteteinaza jest enzim koji je kod ljudi kodiran genom VNN1.

VNN1
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 4CYF, 4CYG, 4CYY
Identifikatori
Aliasi	VNN1
Vanjski ID-jevi	MGI: 108395 HomoloGene: 32130 GeneCards: VNN1
Lokacija gena (čovjek) Hrom. Hromosom 6 (čovjek) Bend 6q23.2 Početak 132,680,849 bp Kraj 132,714,055 bp
Lokacija gena (miš) Hrom. Hromosom 10 (miš) Bend 10|10 A4 Početak 23,770,586 bp Kraj 23,781,241 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides • hydrolase activity • pantetheine hydrolase activity Ćelijska komponenta • integral component of membrane • membrana • anchored component of membrane • extracellular region • ćelijska membrana • azurophil granule membrane Biološki proces • positive regulation of T cell differentiation in thymus • GO:0001306 response to oxidative stress • nitrogen compound metabolic process • acute inflammatory response • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway • Urođeni imunski sistem • inflammatory response • chronic inflammatory response • pantothenate metabolic process • neutrophil degranulation • cell-cell adhesion Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	8876	22361
Ensembl	ENSG00000112299	ENSMUSG00000037440
UniProt	O95497	Q9Z0K8
RefSeq (mRNK)	NM_004666	NM_011704
RefSeq (bjelančevina)	NP_004657	NP_035834
Lokacija (UCSC)	Chr 6: 132.68 – 132.71 Mb	Chr 10: 23.77 – 23.78 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 513 aminokiselina, а molekulska težina 57.012 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MTTQLPAYVA		ILLFYVSRAS		CQDTFTAAVY		EHAAILPNAT		LTPVSREEAL
ALMNRNLDIL		EGAITSAADQ		GAHIIVTPED		AIYGWNFNRD		SLYPYLEDIP
DPEVNWIPCN		NRNRFGQTPV		QERLSCLAKN		NSIYVVANIG		DKKPCDTSDP
QCPPDGRYQY		NTDVVFDSQG		KLVARYHKQN		LFMGENQFNV		PKEPEIVTFN
TTFGSFGIFT		CFDILFHDPA		VTLVKDFHVD		TIVFPTAWMN		VLPHLSAVEF
HSAWAMGMRV		NFLASNIHYP		SKKMTGSGIY		APNSSRAFHY		DMKTEEGKLL
LSQLDSHPSH		SAVVNWTSYA		SSIEALSSGN		KEFKGTVFFD		EFTFVKLTGV
AGNYTVCQKD		LCCHLSYKMS		ENIPNEVYAL		GAFDGLHTVE		GRYYLQICTL
LKCKTTNLNT		CGDSAETAST		RFEMFSLSGT		FGTQYVFPEV		LLSENQLAPG
EFQVSTDGRL		FSLKPTSGPV		LTVTLFGRLY		EKDWASNASS		GLTAQARIIM
LIVIAPIVCS		LSW

Funkcija

Ovaj genski proizvod je član vaninske porodice proteina koji međusobno dijele veliku sličnost sekvenci, kao i sa biotinidazom. Porodica uključuje izlučene i membranom povezane proteine, od kojih je nekoliko prijavljeno da učestvuju u prometu hematopoetskih ćelija. Nijedna biotinidazna aktivnost nije dokazana ni za jedan od vaninski proteina; međutim, oni posjeduju panteteinaznu aktivnost, koja može imati ulogu u odgovoru na oksidativni stres. Ovaj protein, kao i njegov mišji homolog, vjerovatno je GPI usidrena molekula ćelijske površine. Mišji protein eksprimiraju perivaskularne timusne stromske ćelije i reguliraju migraciju progenitornih T-ćelija u timus. Ovaj gen je u neposrednoj blizini i u istoj transkripcijskoj orijentaciji kao i dva druga gena vanina na hromosomu 6q, regija 23-q24.

Dopunska literatura

• Aurrand-Lions M, Galland F, Bazin H, et al. (1997). "Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing". Immunity. 5 (5): 391–405. doi:10.1016/S1074-7613(00)80496-3. PMID 8934567.
• Maras B, Barra D, Duprè S, Pitari G (1999). "Is pantetheinase the actual identity of mouse and human vanin-1 proteins?". FEBS Lett. 461 (3): 149–52. doi:10.1016/S0014-5793(99)01439-8. PMID 10567687. S2CID 25738323.
• Martin F, Malergue F, Pitari G, et al. (2001). "Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes". Immunogenetics. 53 (4): 296–306. doi:10.1007/s002510100327. PMID 11491533. S2CID 10763223.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kristiansen TZ, Bunkenborg J, Gronborg M, et al. (2005). "A proteomic analysis of human bile". Mol. Cell. Proteomics. 3 (7): 715–28. doi:10.1074/mcp.M400015-MCP200. PMID 15084671.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Min-Oo G, Fortin A, Pitari G, et al. (2007). "Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus". J. Exp. Med. 204 (3): 511–24. doi:10.1084/jem.20061252. PMC 2137903. PMID 17312006.