VTCN1
V-set domen sa T-ćelijskim inhibitorom aktivacije 1 jest protein koji je kod ljudi kodiran genom VTCN1 sa hromosoma 1.[5][6][7]
Aminokiselinska sekvenca uredi
Dužina polipeptidnog lanca je 282 aminokiseline, a molekulska težina 30.878 Da.[8].
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MASLGQILFW | SIISIIIILA | GAIALIIGFG | ISGRHSITVT | TVASAGNIGE | ||||
| DGILSCTFEP | DIKLSDIVIQ | WLKEGVLGLV | HEFKEGKDEL | SEQDEMFRGR | ||||
| TAVFADQVIV | GNASLRLKNV | QLTDAGTYKC | YIITSKGKGN | ANLEYKTGAF | ||||
| SMPEVNVDYN | ASSETLRCEA | PRWFPQPTVV | WASQVDQGAN | FSEVSNTSFE | ||||
| LNSENVTMKV | VSVLYNVTIN | NTYSCMIEND | IAKATGDIKV | TESEIKRRSH | ||||
| LQLLNSKASL | CVSSFFAISW | ALLPLSPYLM | LK |
Funkcija uredi
B7H4 pripada porodici B7 (vidi CD80; MIM 112203) kostimulatornih proteina. Ovi proteini se eksprimiraju na površini antigen-prezentirajućih ćelija i stupaju u interakciju sa ligandima (npr. CD28; MIM 186760) na T-limfocitima (prema OMIM)[7]
B7-H4 je molekula imunske kontrolne tačke.
Također pogledajte uredi
References uredi
- ^ a b c GRCh38: Ensembl release 89: ENSG00000134258 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051076 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Sica GL, Choi IH, Zhu G, Tamada K, Wang SD, Tamura H, Chapoval AI, Flies DB, Bajorath J, Chen L (juni 2003). "B7-H4, a molecule of the B7 family, negatively regulates T cell immunity". Immunity. 18 (6): 849–61. doi:10.1016/S1074-7613(03)00152-3. PMID 12818165.
- ^ Prasad DV, Richards S, Mai XM, Dong C (juni 2003). "B7S1, a novel B7 family member that negatively regulates T cell activation". Immunity. 18 (6): 863–73. doi:10.1016/S1074-7613(03)00147-X. PMID 12818166.
- ^ a b "Entrez Gene: VTCN1 V-set domain containing T cell activation inhibitor 1".
- ^ "UniProt, Q7Z7D3" (jezik: eng.). Pristupljeno 29. 11. 2021.CS1 održavanje: nepoznati jezik (link)
Dopunska literatura uredi
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- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (oktobar 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, Hurchla MA, Zimmerman N, Sim J, Zang X, Murphy TL, Russell JH, Allison JP, Murphy KM (juli 2003). "BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1". Nature Immunology. 4 (7): 670–9. doi:10.1038/ni944. PMID 12796776. S2CID 11943145.
- Zang X, Loke P, Kim J, Murphy K, Waitz R, Allison JP (septembar 2003). "B7x: a widely expressed B7 family member that inhibits T cell activation". Proceedings of the National Academy of Sciences of the United States of America. 100 (18): 10388–92. Bibcode:2003PNAS..10010388Z. doi:10.1073/pnas.1434299100. PMC 193571. PMID 12920180.
- Choi IH, Zhu G, Sica GL, Strome SE, Cheville JC, Lau JS, Zhu Y, Flies DB, Tamada K, Chen L (novembar 2003). "Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family". Journal of Immunology. 171 (9): 4650–4. doi:10.4049/jimmunol.171.9.4650. PMID 14568939.
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- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (januar 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Kryczek I, Zou L, Rodriguez P, Zhu G, Wei S, Mottram P, Brumlik M, Cheng P, Curiel T, Myers L, Lackner A, Alvarez X, Ochoa A, Chen L, Zou W (april 2006). "B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma". The Journal of Experimental Medicine. 203 (4): 871–81. doi:10.1084/jem.20050930. PMC 2118300. PMID 16606666.
- Kryczek I, Wei S, Zou L, Zhu G, Mottram P, Xu H, Chen L, Zou W (juli 2006). "Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells". Journal of Immunology. 177 (1): 40–4. doi:10.4049/jimmunol.177.1.40. PMID 16785496. S2CID 922578.
- Krambeck AE, Thompson RH, Dong H, Lohse CM, Park ES, Kuntz SM, Leibovich BC, Blute ML, Cheville JC, Kwon ED (juli 2006). "B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival". Proceedings of the National Academy of Sciences of the United States of America. 103 (27): 10391–6. Bibcode:2006PNAS..10310391K. doi:10.1073/pnas.0600937103. PMC 1502468. PMID 16798883.
- Chen Y, Yang C, Xie Z, Zou L, Ruan Z, Zhang X, Tang Y, Fei L, Jia Z, Wu Y (decembar 2006). "Expression of the novel co-stimulatory molecule B7-H4 by renal tubular epithelial cells". Kidney International. 70 (12): 2092–9. doi:10.1038/sj.ki.5001867. PMID 17051145.
- Simon I, Katsaros D, Rigault de la Longrais I, Massobrio M, Scorilas A, Kim NW, Sarno MJ, Wolfert RL, Diamandis EP (august 2007). "B7-H4 is over-expressed in early-stage ovarian cancer and is independent of CA125 expression". Gynecologic Oncology. 106 (2): 334–41. doi:10.1016/j.ygyno.2007.03.035. PMID 17498784.
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