VNN2

VNN2
Identifikatori
Aliasi	VNN2
Vanjski ID-jevi	OMIM: 603571 HomoloGene: 130041 GeneCards: VNN2
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	132,763,459 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; • hydrolase activity; • pantetheine hydrolase activity;
Ćelijska komponenta	• anchored component of membrane; • membrana; • extracellular region; • ćelijska membrana;
Biološki proces	• nitrogen compound metabolic process; • pantothenate metabolic process;
	Izvori:Amigo / QuickGO
Ortolozi
	8875
	n/a
	ENSG00000112303
	n/a
	O95498
	n/a
	NM_001242350; NM_004665; NM_078488
	n/a
	NP_001229279; NP_004656; NP_511043
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Vaskularna neupalna molekula 2 jest protein koji je kod ljudi kodiran genom VNN2.^[3]^[4]^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 520 aminokiselina, а molekulska težina 58.503 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MVTSSFPISV	AVFALITLQV	GTQDSFIAAV	YEHAVILPNK	TETPVSQEDA
LNLMNENIDI	LETAIKQAAE	QGARIIVTPE	DALYGWKFTR	ETVFPYLEDI
PDPQVNWIPC	QDPHRFGHTP	VQARLSCLAK	DNSIYVLANL	GDKKPCNSRD
STCPPNGYFQ	YNTNVVYNTE	GKLVARYHKY	HLYSEPQFNV	PEKPELVTFN
TAFGRFGIFT	CFDIFFYDPG	VTLVKDFHVD	TILFPTAWMN	VLPLLTAIEF
HSAWAMGMGV	NLLVANTHHV	SLNMTGSGIY	APNGPKVYHY	DMKTELGKLL
LSEVDSHPLS	SLAYPTAVNW	NAYATTIKPF	PVQKNTFRGF	ISRDGFNFTE
LFENAGNLTV	CQKELCCHLS	YRMLQKEENE	VYVLGAFTGL	HGRRRREYWQ
VCTLLKCKTT	NLTTCGRPVE	TASTRFEMFS	LSGTFGTEYV	FPEVLLTEIH
LSPGKFEVLK	DGRLVNKNGS	SGPILTVSLF	GRWYTKDSLY	SSCGTSNSAI
TYLLIFILLM	IIALQNIVML

Funkcija

Ovaj genski proizvod je član aninake porodice proteina koji međusobno dijele veliku sličnost sekvenci, kao i sa biotinidazom. Porodica uključuje izlučene i membranom povezane proteine, od kojih je nekoliko prijavljeno da učestvuju u prometu hematopoetskih ćelija. Nijedna biotinidazna aktivnost nije dokazana ni za jedan od vaninskih proteina, međutim, oni imaju panteteinaznu aktivnost, koja može imati ulogu u odgovoru na oksidativni stres.

Kodirani protein je GPI-usidrena površinska molekula ćelija koji imaju ulogu u transendotelnoj migraciji neutrofila. Ovaj gen nalazi se u neposrednoj blizini i u istoj transkripcijskoj orijentaciji kao i dva druga vaninska gena na hromosomu 6, regija q23-q24. Za ovaj gen opisane su dvije varijante transkripta koje kodiraju različite izoforme.^[5]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112303 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Galland F, Malergue F, Bazin H, Mattei MG, Aurrand-Lions M, Theillet C, Naquet P (Dec 1998). "Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6". Genomics. 53 (2): 203–13. doi:10.1006/geno.1998.5481. PMID 9790769.
^ Martin F, Malergue F, Pitari G, Philippe JM, Philips S, Chabret C, Granjeaud S, Mattei MG, Mungall AJ, Naquet P, Galland F (Aug 2001). "Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes". Immunogenetics. 53 (4): 296–306. doi:10.1007/s002510100327. PMID 11491533. S2CID 10763223.
^ ^a ^b "Entrez Gene: VNN2 vanin 2".
^ "UniProt, O95498" (jezik: engleski). Pristupljeno 6. 10. 2021.

Dopunska literatura

Suzuki K, Watanabe T, Sakurai S, et al. (1999). "A novel glycosylphosphatidyl inositol-anchored protein on human leukocytes: a possible role for regulation of neutrophil adherence and migration". J. Immunol. 162 (7): 4277–84. PMID 10201959.
Dahlgren C, Karlsson A, Sendo F (2001). "Neutrophil secretory vesicles are the intracellular reservoir for GPI-80, a protein with adhesion-regulating potential". J. Leukoc. Biol. 69 (1): 57–62. PMID 11200068.
Watanabe T, Sendo F (2002). "Physical association of beta 2 integrin with GPI-80, a novel glycosylphosphatidylinositol-anchored protein with potential for regulating adhesion and migration". Biochem. Biophys. Res. Commun. 294 (3): 692–4. doi:10.1016/S0006-291X(02)00538-7. PMID 12056825.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Takeda Y, Fu J, Suzuki K, et al. (2003). "Expression of GPI-80, a beta2-integrin-associated glycosylphosphatidylinositol-anchored protein, requires neutrophil differentiation with dimethyl sulfoxide in HL-60 cells". Exp. Cell Res. 286 (2): 199–208. doi:10.1016/S0014-4827(03)00071-5. PMID 12749849.
Sendo D, Takeda Y, Ishikawa H, et al. (2004). "Localization of GPI-80, a beta2-integrin-associated glycosylphosphatidyl-inositol anchored protein, on strongly CD14-positive human monocytes". Immunobiology. 207 (3): 217–21. doi:10.1078/0171-2985-00235. PMID 12777063.
Sasaki H, Ide N, Sendo F, et al. (2004). "Glycosylphosphatidyl inositol-anchored protein (GPI-80) gene expression is correlated with human thymoma stage". Cancer Sci. 94 (9): 809–13. doi:10.1111/j.1349-7006.2003.tb01523.x. PMID 12967480. S2CID 20499237.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Yoshitake H, Takeda Y, Nitto T, et al. (2004). "GPI-80, a beta2 integrin associated glycosylphosphatidylinositol-anchored protein, concentrates on pseudopodia without association with beta2 integrin during neutrophil migration". Immunobiology. 208 (4): 391–9. doi:10.1078/0171-2985-00281. PMID 14748512.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Nitto T, Takeda Y, Yoshitake H, et al. (2007). "Structural divergence of GPI-80 in activated human neutrophils". Biochem. Biophys. Res. Commun. 359 (2): 227–33. doi:10.1016/j.bbrc.2007.05.087. PMID 17543284.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112303 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9790769-3] Galland F, Malergue F, Bazin H, Mattei MG, Aurrand-Lions M, Theillet C, Naquet P (Dec 1998). "Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6". Genomics. 53 (2): 203–13. doi:10.1006/geno.1998.5481. PMID 9790769.

[pmid11491533-4] Martin F, Malergue F, Pitari G, Philippe JM, Philips S, Chabret C, Granjeaud S, Mattei MG, Mungall AJ, Naquet P, Galland F (Aug 2001). "Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes". Immunogenetics. 53 (4): 296–306. doi:10.1007/s002510100327. PMID 11491533. S2CID 10763223.

[entrez-5] "Entrez Gene: VNN2 vanin 2".

[UniProt-6] "UniProt, O95498" (jezik: engleski). Pristupljeno 6. 10. 2021.

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