UNC93A

UNC93A
Identifikatori
Aliasi	UNC93A
Vanjski ID-jevi	OMIM: 607995 MGI: 1933250 HomoloGene: 10356 GeneCards: UNC93A
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	167,316,014 bp
Lokacija gena (miš)
Hrom.	Hromosom 17 (miš)
Kraj	13,350,697 bp
Ontologija gena
Molekularna funkcija	• molekularna funkcija;
Ćelijska komponenta	• membrana; • integral component of membrane; • ćelijska membrana;
Biološki proces	• GO:0022610 biološki proces;
	Izvori:Amigo / QuickGO
Ortolozi
	54346
	381058
	ENSG00000112494
	ENSMUSG00000067049
	Q86WB7
	Q710D3
	NM_001143947; NM_018974
	NM_199252
	NP_001137419; NP_061847
	NP_954860
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Homolog A Unc-93 (C. elegans) jest protein koji je kod ljudi kodiran genom UNC93A.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 457 aminokiselina, а molekulska težina 50.270 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MDRSLRNVLV	VSFGFLLLFT	AYGGLQSLQS	SLYSEEGLGV	TALSTLYGGM
LLSSMFLPPL	LIERLGCKGT	IILSMCGYVA	FSVGNFFASW	YTLIPTSILL
GLGAAPLWSA	QCTYLTITGN	THAEKAGKRG	KDMVNQYFGI	FFLIFQSSGV
WGNLISSLVF	GQTPSQETLP	EEQLTSCGAS	DCLMATTTTN	STQRPSQQLV
YTLLGIYTGS	GVLAVLMIAA	FLQPIRDVQR	ESEGEKKSVP	FWSTLLSTFK
LYRDKRLCLL	ILLPLYSGLQ	QGFLSSEYTR	SYVTCTLGIQ	FVGYVMICFS
ATDALCSVLY	GKVSQYTGRA	VLYVLGAVTH	VSCMIALLLW	RPRADHLAVF
FVFSGLWGVA	DAVWQTQNNA	LYGVLFEKSK	EAAFANYRLW	EALGFVIAFG
YSMFLCVHVK	LYILLGVLSL	TMVAYGLVEC	VESKNPIRPH	APGQVNQAED
EEIQTKM

Funkcija

Kod ljudi, Unc93A je glavna poroduca facilitatora (MFS) i navodna porodica rastvornih nosača.^[7]^[8] Pripada atipskim SL-ovima koji su nedavno opisani.^[7] Stoga se pretpostavlja da je UNC93A proteinski transporter.

Blisko je srodan sa UNC93B1 i MFSD11.^[9]^[10]

Na UNC93A utiče nedostatak aminokiselina u kulturama korteknih ćelija^[8]^[9] i u izgladnjivanju u uvjetima in vivo.^[9]

Eksprimira se u neuronima, sa bojenjem blizu plazmamembrane.^[9]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112494 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000067049 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Unc-93 homolog A (C. elegans)".
^ "UniProt, Q86WB7" (jezik: engleski). Pristupljeno 11. 10. 2021.
^ ^a ^b Perland E, Fredriksson R (mart 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
^ ^a ^b Perland E, Bagchi S, Klaesson A, Fredriksson R (septembar 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.
^ ^a ^b ^c ^d Ceder MM, Lekholm E, Hellsten SV, Perland E, Fredriksson R (2017). "The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice". Frontiers in Molecular Neuroscience (jezik: English). 10: 351. doi:10.3389/fnmol.2017.00351. PMC 5671512. PMID 29163028.CS1 održavanje: nepoznati jezik (link)
^ Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS ONE. 11 (6): e0156912. Bibcode:2016PLoSO..1156912P. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.

Dopunska literatura

^[1]^[2] for functional studies in C.elegans.*^[3]
Liu Y, Dodds P, Emilion G, Mungall AJ, Dunham I, Beck S, Wells RS, Charnock FM, Ganesan TS (oktobar 2002). "The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer". BMC Genetics. 3: 20. doi:10.1186/1471-2156-3-20. PMC 134458. PMID 12381271.

^ Levin JZ, Horvitz HR (april 1992). "The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction". The Journal of Cell Biology. 117 (1): 143–55. doi:10.1083/jcb.117.1.143. PMC 2289394. PMID 1313436.
^ de la Cruz IP, Levin JZ, Cummins C, Anderson P, Horvitz HR (oktobar 2003). "sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans". The Journal of Neuroscience. 23 (27): 9133–45. doi:10.1523/JNEUROSCI.23-27-09133.2003. PMC 6740817. PMID 14534247.
^ Ceder, Mikaela M.; Aggarwal, Tanya; Hosseini, Kimia; Maturi, Varun; Patil, Sourabh; Perland, Emelie; Williams, Michael J.; Fredriksson, Robert (2020). "CG4928 Is Vital for Renal Function in Fruit Flies and Membrane Potential in Cells: A First In-Depth Characterization of the Putative Solute Carrier UNC93A". Frontiers in Cell and Developmental Biology (jezik: English). 8: 580291. doi:10.3389/fcell.2020.580291. ISSN 2296-634X. PMC 7591606. PMID 33163493.CS1 održavanje: nepoznati jezik (link)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112494 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000067049 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Unc-93 homolog A (C. elegans)".

[UniProt-6] "UniProt, Q86WB7" (jezik: engleski). Pristupljeno 11. 10. 2021.

[Perland_2017a-7] Perland E, Fredriksson R (mart 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.

[Perland_2017b-8] Perland E, Bagchi S, Klaesson A, Fredriksson R (septembar 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.

[Ceder_2017-9] Ceder MM, Lekholm E, Hellsten SV, Perland E, Fredriksson R (2017). "The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice". Frontiers in Molecular Neuroscience (jezik: English). 10: 351. doi:10.3389/fnmol.2017.00351. PMC 5671512. PMID 29163028.CS1 održavanje: nepoznati jezik (link)

[10] Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS ONE. 11 (6): e0156912. Bibcode:2016PLoSO..1156912P. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.

[11] Levin JZ, Horvitz HR (april 1992). "The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction". The Journal of Cell Biology. 117 (1): 143–55. doi:10.1083/jcb.117.1.143. PMC 2289394. PMID 1313436.

[12] Cruz IP, Levin JZ, Cummins C, Anderson P, Horvitz HR (oktobar 2003). "sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans". The Journal of Neuroscience. 23 (27): 9133–45. doi:10.1523/JNEUROSCI.23-27-09133.2003. PMC 6740817. PMID 14534247.

[13] Ceder, Mikaela M.; Aggarwal, Tanya; Hosseini, Kimia; Maturi, Varun; Patil, Sourabh; Perland, Emelie; Williams, Michael J.; Fredriksson, Robert (2020). "CG4928 Is Vital for Renal Function in Fruit Flies and Membrane Potential in Cells: A First In-Depth Characterization of the Putative Solute Carrier UNC93A". Frontiers in Cell and Developmental Biology (jezik: English). 8: 580291. doi:10.3389/fcell.2020.580291. ISSN 2296-634X. PMC 7591606. PMID 33163493.CS1 održavanje: nepoznati jezik (link)

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