UNC93A
Homolog A Unc-93 (C. elegans) jest protein koji je kod ljudi kodiran genom UNC93A.[5]
| UNC93A | |||||||||||||||||||||||||
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| Identifikatori | |||||||||||||||||||||||||
| Aliasi | UNC93A | ||||||||||||||||||||||||
| Vanjski ID-jevi | OMIM: 607995 MGI: 1933250 HomoloGene: 10356 GeneCards: UNC93A | ||||||||||||||||||||||||
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| Ortolozi | |||||||||||||||||||||||||
| Vrste | Čovjek | Miš | |||||||||||||||||||||||
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| RefSeq (mRNK) | |||||||||||||||||||||||||
| RefSeq (bjelančevina) | |||||||||||||||||||||||||
| Lokacija (UCSC) | Chr 6: 167.27 – 167.32 Mb | Chr 17: 13.33 – 13.35 Mb | |||||||||||||||||||||||
| PubMed pretraga | [3] | [4] | |||||||||||||||||||||||
| Wikipodaci | |||||||||||||||||||||||||
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Aminokiselinska sekvenca uredi
Dužina polipeptidnog lanca je 457 aminokiselina, а molekulska težina 50.270 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MDRSLRNVLV | VSFGFLLLFT | AYGGLQSLQS | SLYSEEGLGV | TALSTLYGGM | ||||
| LLSSMFLPPL | LIERLGCKGT | IILSMCGYVA | FSVGNFFASW | YTLIPTSILL | ||||
| GLGAAPLWSA | QCTYLTITGN | THAEKAGKRG | KDMVNQYFGI | FFLIFQSSGV | ||||
| WGNLISSLVF | GQTPSQETLP | EEQLTSCGAS | DCLMATTTTN | STQRPSQQLV | ||||
| YTLLGIYTGS | GVLAVLMIAA | FLQPIRDVQR | ESEGEKKSVP | FWSTLLSTFK | ||||
| LYRDKRLCLL | ILLPLYSGLQ | QGFLSSEYTR | SYVTCTLGIQ | FVGYVMICFS | ||||
| ATDALCSVLY | GKVSQYTGRA | VLYVLGAVTH | VSCMIALLLW | RPRADHLAVF | ||||
| FVFSGLWGVA | DAVWQTQNNA | LYGVLFEKSK | EAAFANYRLW | EALGFVIAFG | ||||
| YSMFLCVHVK | LYILLGVLSL | TMVAYGLVEC | VESKNPIRPH | APGQVNQAED | ||||
| EEIQTKM |
Funkcija uredi
Kod ljudi, Unc93A je glavna poroduca facilitatora (MFS) i navodna porodica rastvornih nosača.[7][8] Pripada atipskim SL-ovima koji su nedavno opisani.[7] Stoga se pretpostavlja da je UNC93A proteinski transporter.
Blisko je srodan sa UNC93B1 i MFSD11.[9][10]
Na UNC93A utiče nedostatak aminokiselina u kulturama korteknih ćelija[8][9] i u izgladnjivanju u uvjetima in vivo.[9]
Eksprimira se u neuronima, sa bojenjem blizu plazmamembrane.[9]
Reference uredi
- ^ a b c GRCh38: Ensembl release 89: ENSG00000112494 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067049 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Unc-93 homolog A (C. elegans)".
- ^ "UniProt, Q86WB7" (jezik: engleski). Pristupljeno 11. 10. 2021.
- ^ a b Perland E, Fredriksson R (mart 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
- ^ a b Perland E, Bagchi S, Klaesson A, Fredriksson R (septembar 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.
- ^ a b c d Ceder MM, Lekholm E, Hellsten SV, Perland E, Fredriksson R (2017). "The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice". Frontiers in Molecular Neuroscience (jezik: English). 10: 351. doi:10.3389/fnmol.2017.00351. PMC 5671512. PMID 29163028.CS1 održavanje: nepoznati jezik (link)
- ^ Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS ONE. 11 (6): e0156912. Bibcode:2016PLoSO..1156912P. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.
Dopunska literatura uredi
- [1][2] for functional studies in C.elegans.*[3]
- Liu Y, Dodds P, Emilion G, Mungall AJ, Dunham I, Beck S, Wells RS, Charnock FM, Ganesan TS (oktobar 2002). "The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer". BMC Genetics. 3: 20. doi:10.1186/1471-2156-3-20. PMC 134458. PMID 12381271.
- ^ Levin JZ, Horvitz HR (april 1992). "The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction". The Journal of Cell Biology. 117 (1): 143–55. doi:10.1083/jcb.117.1.143. PMC 2289394. PMID 1313436.
- ^ de la Cruz IP, Levin JZ, Cummins C, Anderson P, Horvitz HR (oktobar 2003). "sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans". The Journal of Neuroscience. 23 (27): 9133–45. doi:10.1523/JNEUROSCI.23-27-09133.2003. PMC 6740817. PMID 14534247.
- ^ Ceder, Mikaela M.; Aggarwal, Tanya; Hosseini, Kimia; Maturi, Varun; Patil, Sourabh; Perland, Emelie; Williams, Michael J.; Fredriksson, Robert (2020). "CG4928 Is Vital for Renal Function in Fruit Flies and Membrane Potential in Cells: A First In-Depth Characterization of the Putative Solute Carrier UNC93A". Frontiers in Cell and Developmental Biology (jezik: English). 8: 580291. doi:10.3389/fcell.2020.580291. ISSN 2296-634X. PMC 7591606. PMID 33163493.CS1 održavanje: nepoznati jezik (link)