LSM1

LSM1
Identifikatori
Aliasi	LSM1
Vanjski ID-jevi	OMIM: 607281 MGI: 1914457 HomoloGene: 40945 GeneCards: LSM1
Lokacija gena (miš)
Hrom.	Hromosom 8 (miš)
Kraj	26,294,003 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • RNA cap binding; • pre-mRNA binding; • mRNA binding; • vezivanje sa RNK;
Ćelijska komponenta	• citosol; • P-tijelo; • messenger ribonucleoprotein complex; • Akson; • soma; • dendrit; • jedro; • citoplazma; • mRNA cap binding complex; • Lsm1-7-Pat1 complex;
Biološki proces	• negative regulation of neuron differentiation; • deadenylation-dependent decapping of nuclear-transcribed mRNA; • RNA splicing, via transesterification reactions; • mRNA processing; • stem cell population maintenance; • Prerada RNK; • exonucleolytic catabolism of deadenylated mRNA; • histone mRNA catabolic process; • nuclear-transcribed mRNA catabolic process; • RNA metabolic process;
	Izvori:Amigo / QuickGO
Ortolozi
	27257
	67207
	n/a
	ENSMUSG00000037296
	O15116
	Q8VC85
	NM_014462
	NM_026032
	NP_055277
	NP_080308
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

U6 snRNK-pridruženi Sm-oliki protein LSm1 je protein koji je kod ljudi kodiran genom LSM1.^[4]^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 133 aminokiseline, а molekulska težina 15.179 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MNYMPGTASL	IEDIDKKHLV	LLRDGRTLIG	FLRSIDQFAN	LVLHQTVERI
HVGKKYGDIP	RGIFVVRGEN	VVLLGEIDLE	KESDTPLQQV	SIEEILEEQR
VEQQTKLEAE	KLKVQALKDR	GLSIPRADTL	DEY

Funkcija

Smoliki proteini su identifikovani u različitim organizmima na osnovu homologije sekvenci sa porodicom Sm-proteina (vidi SNRPD2). Proteini slični Sm-u sadrže motiv Sm sekvence, koji se sastoji od dvije regije odvojene poveznicom promjenjive dužine koja se savija kao petlja. Smatra se da proteini slični Sm tvore stabilan heteromer prisutan u tri-snRNP česticama, koji su važni u prepreradi iRNK.^[6]

Reference

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037296 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ingelfinger D, Arndt-Jovin DJ, Luhrmann R, Achsel T (Jan 2003). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci". RNA. 8 (12): 1489–501. doi:10.1017/S1355838202021726 (neaktivno 31. 5. 2021). PMC 1370355. PMID 12515382.CS1 održavanje: DOI nije aktivan od 2021 (link)
^ Takahashi S, Suzuki S, Inaguma S, Cho YM, Ikeda Y, Hayashi N, Inoue T, Sugimura Y, Nishiyama N, Fujita T, Ushijima T, Shirai T (Apr 2002). "Down-regulation of Lsm1 is involved in human prostate cancer progression". Br J Cancer. 86 (6): 940–6. doi:10.1038/sj.bjc.6600163. PMC 2364150. PMID 11953827.
^ ^a ^b "Entrez Gene: LSM1 LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)".
^ "UniProt, O15116" (jezik: engleski). Pristupljeno 19. 9. 2021.

Dopunska literatura

Shimizu Y, Sugiyama H, Fujii Y, et al. (1997). "Lineage- and differentiation stage-specific expression of LSM-1 (LPAP), a possible substrate for CD45, in human hematopoietic cells". Am. J. Hematol. 54 (1): 1–11. doi:10.1002/(SICI)1096-8652(199701)54:1<1::AID-AJH1>3.0.CO;2-1. PMID 8980254.
Schweinfest CW, Graber MW, Chapman JM, et al. (1997). "CaSm: an Sm-like protein that contributes to the transformed state in cancer cells". Cancer Res. 57 (14): 2961–5. PMID 9230209.
Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Séraphin B (1999). "Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin". EMBO J. 18 (12): 3451–62. doi:10.1093/emboj/18.12.3451. PMC 1171424. PMID 10369684.
Achsel T, Brahms H, Kastner B, et al. (1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro". EMBO J. 18 (20): 5789–802. doi:10.1093/emboj/18.20.5789. PMC 1171645. PMID 10523320.
Friesen WJ, Dreyfuss G (2000). "Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN)". J. Biol. Chem. 275 (34): 26370–5. doi:10.1074/jbc.M003299200. PMID 10851237.
Eystathioy T, Peebles CL, Hamel JC, et al. (2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera". Arthritis Rheum. 46 (3): 726–34. doi:10.1002/art.10220. PMID 11920408.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Wichroski MJ, Robb GB, Rana TM (2006). "Human Retroviral Host Restriction Factors APOBEC3G and APOBEC3F Localize to mRNA Processing Bodies". PLOS Pathog. 2 (5): e41. doi:10.1371/journal.ppat.0020041. PMC 1458959. PMID 16699599.
Chu CY, Rana TM (2006). "Translation Repression in Human Cells by MicroRNA-Induced Gene Silencing Requires RCK/p54". PLOS Biol. 4 (7): e210. doi:10.1371/journal.pbio.0040210. PMC 1475773. PMID 16756390.
Streicher KL, Yang ZQ, Draghici S, Ethier SP (2007). "Transforming function of the LSM1 oncogene in human breast cancers with the 8p11−12 amplicon". Oncogene. 26 (14): 2104–14. doi:10.1038/sj.onc.1210002. PMC 2435249. PMID 17001308.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000037296 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12515382-4] Ingelfinger D, Arndt-Jovin DJ, Luhrmann R, Achsel T (Jan 2003). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci". RNA. 8 (12): 1489–501. doi:10.1017/S1355838202021726 (neaktivno 31. 5. 2021). PMC 1370355. PMID 12515382.CS1 održavanje: DOI nije aktivan od 2021 (link)

[pmid11953827-5] Takahashi S, Suzuki S, Inaguma S, Cho YM, Ikeda Y, Hayashi N, Inoue T, Sugimura Y, Nishiyama N, Fujita T, Ushijima T, Shirai T (Apr 2002). "Down-regulation of Lsm1 is involved in human prostate cancer progression". Br J Cancer. 86 (6): 940–6. doi:10.1038/sj.bjc.6600163. PMC 2364150. PMID 11953827.

[entrez-6] "Entrez Gene: LSM1 LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)".

[UniProt-7] "UniProt, O15116" (jezik: engleski). Pristupljeno 19. 9. 2021.

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