Membranski protein 2 na translokacijskom lancu jest protein koji je kod ljudi kodiran genom TRAM2.[3][4][5]

TSBP1
Identifikatori
AliasiTSBP1
Vanjski ID-jeviOMIM: 618151 HomoloGene: 81753 GeneCards: TSBP1
Lokacija gena (čovjek)
Hromosom 6 (čovjek)
Hrom.Hromosom 6 (čovjek)[1]
Hromosom 6 (čovjek)
Genomska lokacija za TSBP1
Genomska lokacija za TSBP1
Bend6p21.32Početak32,288,526 bp[1]
Kraj32,371,912 bp[1]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
ENSG00000206245
ENSG00000236672
ENSG00000204296
ENSG00000206310
ENSG00000234280
UniProt
RefSeq (mRNK)

NM_001286474
NM_001286475
NM_006781

n/a

RefSeq (bjelančevina)

NP_001273403
NP_001273404
NP_006772

n/a

Lokacija (UCSC)Chr 6: 32.29 – 32.37 Mbn/a
PubMed pretraga[2]n/a
Wikipodaci
Pogledaj/uredi – čovjek

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 370 aminokiselina, а molekulska težina 43.328 Da.[6]

1020304050
MAFRRRTKSYPLFSQEFVIHNHADIGFCLVLCVLIGLMFEVTAKTAFLFI
LPQYNISVPTADSETVHYHYGPKDLVTILFYIFITIILHAVVQEYILDKI
SKRLHLSKVKHSKFNESGQLVVFHFTSVIWCFYVVVTEGYLTNPRSLWED
YPHVHLPFQVKFFYLCQLAYWLHALPELYFQKVRKEEIPRQLQYICLYLV
HIAGAYLLNLSRLGLILLLLQYSTEFLFHTARLFYFADENNEKLFSAWAA
VFGVTRLFILTLAVLAIGFGLARMENQAFDPEKGNFNTLFCRLCVLLLVC
AAQAWLMWRFIHSQLRHWREYWNEQSAKRRVPATPRLPARLIKRESGYHE
NGVVKAENGTSPRTKKLKSP

Funkcija

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TRAM2 je komponenta translokona, zatvorenog makromolekulskog kanala koji kontrolira posttranslacijsku obradu nastajućih sekretornih i membranskih proteina na membrani endoplazmatskog retikuluma (ER).[5]

Reference

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  1. ^ a b c ENSG00000236672, ENSG00000204296, ENSG00000206310, ENSG00000234280, ENSG00000237881, ENSG00000232106, ENSG00000226892 GRCh38: Ensembl release 89: ENSG00000206245, ENSG00000236672, ENSG00000204296, ENSG00000206310, ENSG00000234280, ENSG00000237881, ENSG00000232106, ENSG00000226892 - Ensembl, maj 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
  4. ^ Onuchic LF, Mrug M, Lakings AL, Muecher G, Becker J, Zerres K, Avner ED, Dixit M, Somlo S, Germino GG, Guay-Woodford LM (Jan 2000). "Genomic organization of the KIAA0057 gene that encodes a TRAM-like protein and its exclusion as a polycystic kidney and hepatic disease 1 (PKHD1) candidate gene". Mamm Genome. 10 (12): 1175–8. doi:10.1007/s003359901186. PMID 10594243. S2CID 11705244.
  5. ^ a b "Entrez Gene: TRAM2 translocation associated membrane protein 2".
  6. ^ "UniProt, Q15035" (jezik: engleski). Pristupljeno 5. 10. 2021.

Dopunska literatuta

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