TRAPPC3

Podjedinica 3 prometujućih čestica proteinskog kompleksa jest protein koji je kod ljudi kodiran genom TRAPPC3 sa hromosoma 1.

TRAPPC3
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1SZ7, 2C0J, 2CFH, 3KXC
Identifikatori
Aliasi	TRAPPC3
Vanjski ID-jevi	OMIM: 610955 MGI: 1351486 HomoloGene: 6399 GeneCards: TRAPPC3
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek) Bend 1p34.3 Početak 36,136,570 bp Kraj 36,156,053 bp
Lokacija gena (miš) Hrom. Hromosom 4 (miš) Bend 4|4 D2.2 Početak 126,156,118 bp Kraj 126,169,676 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • Golđijev aparat • Endoplazmatski retikulum • Golđijeva membrana • citosol • TRAPP complex • cis-Golgi network membrane Biološki proces • COPII vesicle coating • vesicle-mediated transport • Golgi vesicle transport • endoplasmic reticulum to Golgi vesicle-mediated transport • intra-Golgi vesicle-mediated transport Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	27095	27096
Ensembl	ENSG00000054116	ENSMUSG00000028847
UniProt	O43617	O55013
RefSeq (mRNK)	NM_001270894 NM_001270895 NM_001270896 NM_001270897 NM_014408	NM_013718
RefSeq (bjelančevina)	NP_001257823 NP_001257824 NP_001257825 NP_001257826 NP_055223	NP_038746
Lokacija (UCSC)	Chr 1: 36.14 – 36.16 Mb	Chr 4: 126.16 – 126.17 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 180 aminokiselina, a molekulska težina Da. 20 274

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MSRQANRGTE		SKKMSSELFT		LTYGALVTQL		CKDYENDEDV		NKQLDKMGFN
IGVRLIEDFL		ARSNVGRCHD		FRETADVIAK		VAFKMYLGIT		PSITNWSPAG
DEFSLILENN		PLVDFVELPD		NHSSLIYSNL		LCGVLRGALE		MVQMAVEAKF
VQDTLKGDGV		TEIRMRFIRR		IEDNLPAGEE

Dopunska literatura

• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Sacher M, Jiang Y, Barrowman J, et al. (1998). "TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion". EMBO J. 17 (9): 2494–503. doi:10.1093/emboj/17.9.2494. PMC 1170591. PMID 9564032.
• Barrowman J, Sacher M, Ferro-Novick S (2000). "TRAPP stably associates with the Golgi and is required for vesicle docking". EMBO J. 19 (5): 862–9. doi:10.1093/emboj/19.5.862. PMC 305626. PMID 10698928.
• Gavin AC, Bösche M, Krause R, et al. (2002). "Functional organization of the yeast proteome by systematic analysis of protein complexes". Nature. 415 (6868): 141–7. Bibcode:2002Natur.415..141G. doi:10.1038/415141a. PMID 11805826. S2CID 4425555.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kim YG, Sohn EJ, Seo J, et al. (2005). "Crystal structure of bet3 reveals a novel mechanism for Golgi localization of tethering factor TRAPP". Nat. Struct. Mol. Biol. 12 (1): 38–45. doi:10.1038/nsmb871. PMID 15608655. S2CID 22597154.
• Turnbull AP, Kümmel D, Prinz B, et al. (2005). "Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization". EMBO J. 24 (5): 875–84. doi:10.1038/sj.emboj.7600565. PMC 554119. PMID 15692564.
• Loh E, Peter F, Subramaniam VN, Hong W (2005). "Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus" (PDF). J. Cell Sci. 118 (Pt 6): 1209–22. doi:10.1242/jcs.01723. PMID 15728249. S2CID 3092909.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Kim MS, Yi MJ, Lee KH, et al. (2006). "Biochemical and crystallographic studies reveal a specific interaction between TRAPP subunits Trs33p and Bet3p". Traffic. 6 (12): 1183–95. doi:10.1111/j.1600-0854.2005.00352.x. PMID 16262728.
• Kümmel D, Müller JJ, Roske Y, et al. (2006). "Structure of the Bet3-Tpc6B core of TRAPP: two Tpc6 paralogs form trimeric complexes with Bet3 and Mum2". J. Mol. Biol. 361 (1): 22–32. doi:10.1016/j.jmb.2006.06.012. PMID 16828797.
• Yu S, Satoh A, Pypaert M, et al. (2006). "mBet3p is required for homotypic COPII vesicle tethering in mammalian cells". J. Cell Biol. 174 (3): 359–68. doi:10.1083/jcb.200603044. PMC 2064232. PMID 16880271.
• Kümmel D, Heinemann U, Veit M (2006). "Unique self-palmitoylation activity of the transport protein particle component Bet3: A mechanism required for protein stability". Proc. Natl. Acad. Sci. U.S.A. 103 (34): 12701–6. Bibcode:2006PNAS..10312701K. doi:10.1073/pnas.0603513103. PMC 1562543. PMID 16908848.