Ciljni EGR1 protein 1 jest protein koji je kod ljudi kodiran genom TOE1 sa hromosoma 1.[5][6]

TOE1
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

2FC6

Identifikatori
AliasiTOE1
Vanjski ID-jeviOMIM: 613931 MGI: 1915526 HomoloGene: 11823 GeneCards: TOE1
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za TOE1
Genomska lokacija za TOE1
Bend1p34.1Početak45,340,052 bp[1]
Kraj45,343,973 bp[1]
Lokacija gena (miš)
Hromosom 4 (miš)
Hrom.Hromosom 4 (miš)[2]
Hromosom 4 (miš)
Genomska lokacija za TOE1
Genomska lokacija za TOE1
Bend4|4 D1Početak116,651,507 bp[2]
Kraj116,664,837 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija 3'-5'-exoribonuclease activity
GO:0001948, GO:0016582 vezivanje za proteine
vezivanje iona metala
nucleic acid binding
poly(A)-specific ribonuclease activity
snRNA binding
GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
Ćelijska komponenta citoplazma
Cajal body
nuclear speck
Jedarce
nukleoplazma
jedro
nuclear body
Biološki proces RNA phosphodiester bond hydrolysis, exonucleolytic
snRNA 3'-end processing
GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_025077

NM_026654

RefSeq (bjelančevina)

NP_079353

NP_080930

Lokacija (UCSC)Chr 1: 45.34 – 45.34 MbChr 4: 116.65 – 116.66 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 510 aminokiselina, a molekulska težina 56.548 Da.[7]

1020304050
MAADSDDGAVSAPAASDGGVSKSTTSGEELVVQVPVVDVQSNNFKEMWPS
LLLAIKTANFVAVDTELSGLGDRKSLLNQCIEERYKAVCHAARTRSILSL
GLACFKRQPDKGEHSYLAQVFNLTLLCMEEYVIEPKSVQFLIQHGFNFNQ
QYAQGIPYHKGNDKGDESQSQSVRTLFLELIRARRPLVLHNGLIDLVFLY
QNFYAHLPESLGTFTADLCEMFPAGIYDTKYAAEFHARFVASYLEYAFRK
CERENGKQRAAGSPHLTLEFCNYPSSMRDHIDYRCCLPPATHRPHPTSIC
DNFSAYGWCPLGPQCPQSHDIDLIIDTDEAAAEDKRRRRRRREKRKRALL
NLPGTQTSGEAKDGPPKKQVCGDSIKPEETEQEVAADETRNLPHSKQGNK
NDLEMGIKAARPEIADRATSEVPGSQASPNPVPGDGLHRAGFDAFMTGYV
MAYVEVSQGPQPCSSGPWLPECHNKVYLSGKAVPLTVAKSQFSRSSKAHN
QKMKLTWGSS

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132773 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028688 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ De Belle I, Wu JX, Sperandio S, Mercola D, Adamson ED (Apr 2003). "In vivo cloning and characterization of a new growth suppressor protein TOE1 as a direct target gene of Egr1". J Biol Chem. 278 (16): 14306–12. doi:10.1074/jbc.M210502200. PMID 12562764.
  6. ^ "Entrez Gene: TOE1 target of EGR1, member 1 (nuclear)".
  7. ^ "UniProt, Q96GM8" (jezik: eng.). Pristupljeno 3. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

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