Tenascin N jest protein koji je kod ljudi kodiran genom TNN sa hromosoma 1.[5]

TNN (gen)
Identifikatori
AliasiTNN
Vanjski ID-jeviOMIM: 617472 MGI: 2665790 HomoloGene: 18634 GeneCards: TNN
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za TNN (gen)
Genomska lokacija za TNN (gen)
Bend1q25.1Početak175,067,833 bp[1]
Kraj175,148,075 bp[1]
Lokacija gena (miš)
Hromosom 1 (miš)
Hrom.Hromosom 1 (miš)[2]
Hromosom 1 (miš)
Genomska lokacija za TNN (gen)
Genomska lokacija za TNN (gen)
Bend1|1 H2.1Početak159,912,599 bp[2]
Kraj159,981,150 bp[2]
Ontologija gena
Molekularna funkcija integrin binding
vezivanje identičnih proteina
molekularna funkcija
Ćelijska komponenta extracellular region
cell surface
ćelijska komponenta
neuron projection
soma
CA3 pyramidal cell dendrite
hippocampal mossy fiber expansion
GO:0005578 Vanćelijski matriks
Biološki proces cell-matrix adhesion
axonogenesis
osteoblast development
negative regulation of osteoblast proliferation
negative regulation of osteoblast differentiation
negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation
dendrite self-avoidance
negative regulation of neuron migration
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_022093

NM_177839

RefSeq (bjelančevina)

NP_071376

NP_808507

Lokacija (UCSC)Chr 1: 175.07 – 175.15 MbChr 1: 159.91 – 159.98 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 1.299 aminokiselina, a molekulska težina 144 034 Da.[6]

1020304050
MSLQEMFRFPMGLLLGSVLLVASAPATLEPPGCSNKEQQVTVSHTYKIDV
PKSALVQVDADPQPLSDDGASLLALGEAREEQNIIFRHNIRLQTPQKDCE
LAGSVQDLLARVKKLEEEMVEMKEQCSAQRCCQGVTDLSRHCSGHGTFSL
ETCSCHCEEGREGPACERLACPGACSGHGRCVDGRCLCHEPYVGADCGYP
ACPENCSGHGECVRGVCQCHEDFMSEDCSEKRCPGDCSGHGFCDTGECYC
EEGFTGLDCAQVVTPQGLQLLKNTEDSLLVSWEPSSQVDHYLLSYYPLGK
ELSGKQIQVPKEQHSYEILGLLPGTKYIVTLRNVKNEVSSSPQHLLATTD
LAVLGTAWVTDETENSLDVEWENPSTEVDYYKLRYGPMTGQEVAEVTVPK
SSDPKSRYDITGLHPGTEYKITVVPMRGELEGKPILLNGRTEIDSPTNVV
TDRVTEDTATVSWDPVQAVIDKYVVRYTSADGDTKEMAVHKDESSTVLTG
LKPGEAYKVYVWAERGNQGSKKADTNALTEIDSPANLVTDRVTENTATIS
WDPVQATIDKYVVRYTSADDQETREVLVGKEQSSTVLTGLRPGVEYTVHV
WAQKGDRESKKADTNAPTDIDSPKNLVTDRVTENMATVSWDPVQAAIDKY
VVRYTSAGGETREVPVGKEQSSTVLTGLRPGMEYMVHVWAQKGDQESKKA
DTKAQTDIDSPQNLVTDRVTENMATVSWDPVRATIDRYVVRYTSAKDGET
REVPVGKEQSSTVLTGLRPGVEYTVHVWAQKGAQESKKADTKAQTDIDSP
QNLVTDWVTENTATVSWDPVQATIDRYVVHYTSANGETREVPVGKEQSST
VLTGLRPGMEYTVHVWAQKGNQESKKADTKAQTEIDGPKNLVTDWVTENM
ATVSWDPVQATIDKYMVRYTSADGETREVPVGKEHSSTVLTGLRPGMEYM
VHVWAQKGAQESKKADTKAQTELDPPRNLRPSAVTQSGGILTWTPPSAQI
HGYILTYQFPDGTVKEMQLGREDQRFALQGLEQGATYPVSLVAFKGGRRS
RNVSTTLSTVGARFPHPSDCSQVQQNSNAASGLYTIYLHGDASRPLQVYC
DMETDGGGWIVFQRRNTGQLDFFKRWRSYVEGFGDPMKEFWLGLDKLHNL
TTGTPARYEVRVDLQTANESAYAIYDFFQVASSKERYKLTVGKYRGTAGD
ALTYHNGWKFTTFDRDNDIALSNCALTHHGGWWYKNCHLANPNGRYGETK
HSEGVNWEPWKGHEFSIPYVELKIRPHGYSREPVLGRKKRTLRGRLRTF

Refrerence

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120332 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026725 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "HUGO Gene Nomenclature Commitee, HGNC:22942" (jezik: engleski). Arhivirano s originala, 24. 8. 2017. Pristupljeno 12. 4. 2022.
  6. ^ "UniProt, Q9UQP3" (jezik: engleski). Pristupljeno 18. 9. 2018.

Dopunska literatura

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  • NIH (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14: 2121–2127. PubMed doi:10.1101/gr.2596504

Vanjski linkovi

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