Tuberoinfundibulski peptid od 39 ostataka je protein koji je kod ljudi kodiran genom PTH2 .[ 5] [ 6]
TIP39 povezan je s paratiroidnim hormonom (PTH; MIM 168450 ) i s proteinima povezanim s PTH (PTHRP; MIM 168470) i ligand je za PTH receptor-2 (PTHR2; MIM 601469), prema OMIM -u.[ 6]
Molekulska interakcija TIP39 s receptorima PTH2 okarakterizirana je u 3D detaljima, identificirajući među ostalim ostacima Tyr-318 u transmembranskoj spirali 5, kao ključni ostatak za vezanje s visokim afinitetom [ 7]
Aminokiselinska sekvenca
uredi
Simboli
10 20 30 40 50 METRQVSRSP RVRLLLLLLL LLVVPWGVRT ASGVALPPVG VLSLRPPGRA WADPATPRPR RSLALADDAA FRERARLLAA LERRHWLNSY MHKLLVLDAP
^ a b c GRCh38: Ensembl release 89: ENSG00000142538 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038300 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ John MR, Arai M, Rubin DA, Jonsson KB, Juppner H (Feb 2002). "Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues" . Endocrinology . 143 (3): 1047–57. doi :10.1210/en.143.3.1047 PMID 11861531 . ^ a b "Entrez Gene: TIP39 tuberoinfundibular 39 residue protein precursor" .^ Weaver RE, Mobarec JC, Wigglesworth MJ, Reynolds CA, Donnelly D (2017). "High affinity binding of the peptide agonist TIP-39 to the Parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5" . Biochemical Pharmacology . 127 : 71–81. doi :10.1016/j.bcp.2016.12.013 . PMC 5303546 PMID 28012961 .
Dopunska literatura
uredi
Usdin TB, Hoare SR, Wang T, et al. (1999). "TIP39: a new neuropeptide and PTH2-receptor agonist from hypothalamus". Nat. Neurosci . 2 (11): 941–3. doi :10.1038/14724 . PMID 10526330 . S2CID 22744817 . Hoare SR, Clark JA, Usdin TB (2000). "Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity" . J. Biol. Chem . 275 (35): 27274–83. doi :10.1074/jbc.M003910200 PMID 10854439 . Dobolyi A, Ueda H, Uchida H, et al. (2002). "Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception" . Proc. Natl. Acad. Sci. U.S.A . 99 (3): 1651–6. doi :10.1073/pnas.042416199 . PMC 122245 PMID 11818570 . Hansen IA, Jakob O, Wortmann S, et al. (2002). "Characterization of the human and mouse genes encoding the tuberoinfundibular peptide of 39 residues, a ligand of the parathyroid hormone receptor family" . J. Endocrinol . 174 (1): 95–102. doi :10.1677/joe.0.1740095 PMID 12098667 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 . Della Penna K, Kinose F, Sun H, et al. (2003). "Tuberoinfundibular peptide of 39 residues (TIP39): molecular structure and activity for parathyroid hormone 2 receptor" . Neuropharmacology . 44 (1): 141–53. doi :10.1016/S0028-3908(02)00335-0 . PMID 12559132 . S2CID 9974844 . Misiano P, Scott BB, Scheideler MA, Garnier M (2004). "PTH2 receptor-mediated inhibitory effect of parathyroid hormone and TIP39 on cell proliferation". Eur. J. Pharmacol . 468 (3): 159–66. doi :10.1016/S0014-2999(03)01673-X . PMID 12754053 . Bisello A, Manen D, Pierroz DD, et al. (2004). "Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization" . Mol. Endocrinol . 18 (6): 1486–98. doi :10.1210/me.2003-0487 PMID 14988434 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . 
