TIMM10B
Podjedinica Tim9 B mitohondrijske importne unutrašnjo
membranske translokaze je enzim koji je kod ljudi kodiran genom FXC1.[5][6]
FXC1 ili TIMM10B, pripada porodici evolucijski konzerviranih proteina koji su organizirani u heterooligomerne komplekse u mitohondrijskom intermembranskom prostoru. Ovi proteini posreduju pri importu i inserciji proteina hidrofobne membrane u unutrašnju membranu mitohondrija (prema OMIM.[6]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 103 aminokiseline, а molekulska težina 11.586 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MERQQQQQQQ | LRNLRDFLLV | YNRMTELCFQ | RCVPSLHHRA | LDAEEEACLH | ||||
| SCAGKLIHSN | HRLMAAYVQL | MPALVQRRIA | DYEAASAVPG | VAAEQPGVSP | ||||
| SGS |
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000132286 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000089847 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Jin H, Kendall E, Freeman TC, Roberts RG, Vetrie DL (Feb 2000). "The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins". Genomics. 61 (3): 259–67. doi:10.1006/geno.1999.5966. PMID 10552927.
- ^ a b "Entrez Gene: FXC1 fracture callus 1 homolog (rat)".
- ^ "UniProt, Q9Y5J6". Pristupljeno 28. 8. 2021.
Dopunska literatura
uredi- Hadjiargyrou M, Halsey MF, Ahrens W, et al. (1998). "Cloning of a novel cDNA expressed during the early stages of fracture healing". Biochem. Biophys. Res. Commun. 249 (3): 879–84. doi:10.1006/bbrc.1998.9167. PMID 9731230.
- Bauer MF, Rothbauer U, Mühlenbein N, et al. (2000). "The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom". FEBS Lett. 464 (1–2): 41–7. doi:10.1016/S0014-5793(99)01665-8. PMID 10611480. S2CID 27484018.
- Rothbauer U, Hofmann S, Mühlenbein N, et al. (2001). "Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria". J. Biol. Chem. 276 (40): 37327–34. doi:10.1074/jbc.M105313200. PMID 11489896.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Mühlenbein N, Hofmann S, Rothbauer U, Bauer MF (2004). "Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria". J. Biol. Chem. 279 (14): 13540–6. doi:10.1074/jbc.M312485200. PMID 14726512.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.