THG1L

THG1L
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	3OTB, 3OTC, 3OTD, 3OTE
Identifikatori
Aliasi	THG1L
Vanjski ID-jevi	MGI: 1913878 HomoloGene: 5959 GeneCards: THG1L
Lokacija gena (čovjek)
Hrom.	Hromosom 5 (čovjek)
Kraj	157,741,449 bp
Lokacija gena (miš)
Hrom.	Hromosom 11 (miš)
Kraj	45,846,321 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• aktivnost sa transferazom; • nucleotide binding; • tRNA binding; • GTP binding; • GO:0001948, GO:0016582 vezivanje za proteine; • ATP binding; • magnesium ion binding; • vezivanje iona metala; • tRNA guanylyltransferase activity; • vezivanje identičnih proteina; • nucleotidyltransferase activity;
Ćelijska komponenta	• citoplazma; • citosol; • mitohondrija;
Biološki proces	• tRNA modification; • protein homotetramerization; • tRNA processing; • tRNA 5'-end processing;
	Izvori:Amigo / QuickGO
Ortolozi
	54974
	66628
	ENSG00000113272
	ENSMUSG00000011254
	Q9NWX6
	Q9CY52
	NM_017872; NM_001317824; NM_001317825; NM_001317826
	NM_001080969; NM_001290737
	NP_001304753; NP_001304754; NP_001304755; NP_060342
	NP_001074438; NP_001277666
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Vjerovatna tRNK(His) guanililtransferaza jest enzim koji je kod ljudi kodiran genom THG1L sa hromosoma 5.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 298 aminokiselina, а molekulska težina 34.831 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MWGACKVKVH	DSLATISITL	RRYLRLGATM	AKSKFEYVRD	FEADDTCLAH
CWVVVRLDGR	NFHRFAEKHN	FAKPNDSRAL	QLMTKCAQTV	MEELEDIVIA
YGQSDEYSFV	FKRKTNWFKR	RASKFMTHVA	SQFASSYVFY	WRDYFEDQPL
LYPPGFDGRV	VVYPSNQTLK	DYLSWRQADC	HINNLYNTVF	WALIQQSGLT
PVQAQGRLQG	TLAADKNEIL	FSEFNINYNN	ELPMYRKGTV	LIWQKVDEVM
TKEIKLPTEM	EGKKMAVTRT	RTKPVPLHCD	IIGDAFWKEH	PEILDEDS

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113272 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000011254 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
^ "Entrez Gene: THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)".
^ "UniProt, Q9NWX6" (jezik: engleski). Pristupljeno 18. 10. 2021.

Dopunska literatura

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Guo D, Hu K, Lei Y, et al. (2005). "Identification and characterization of a novel cytoplasm protein ICF45 that is involved in cell cycle regulation". J. Biol. Chem. 279 (51): 53498–505. doi:10.1074/jbc.M406737200. PMID 15459185.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113272 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000011254 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11230166-5] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[entrez-6] "Entrez Gene: THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)".

[UniProt-7] "UniProt, Q9NWX6" (jezik: engleski). Pristupljeno 18. 10. 2021.

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