TELO2

TELO2
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4PSI
Identifikatori
Aliasi	TELO2
Vanjski ID-jevi	OMIM: 611140 MGI: 1918968 HomoloGene: 41107 GeneCards: TELO2
Lokacija gena (čovjek)
Hrom.	Hromosom 16 (čovjek)
Kraj	1,510,457 bp
Lokacija gena (miš)
Hrom.	Hromosom 17 (miš)
Kraj	25,334,941 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0032947 molecular adaptor activity; • Hsp90 protein binding; • GO:0001948, GO:0016582 vezivanje za proteine; • protein kinase binding; • GO:0032403 protein-containing complex binding; • telomeric DNA binding;
Ćelijska komponenta	• citoplazma; • Telomera; • TORC1 complex; • TORC2 complex; • intracellular anatomical structure; • membrana; • nuclear periphery; • jedro; • hromosom; • citosol; • nuclear body; • ASTRA complex;
Biološki proces	• positive regulation of TORC1 signaling; • protein stabilization; • regulation of TOR signaling; • positive regulation of TORC2 signaling; • positive regulation of protein serine/threonine kinase activity; • telomere maintenance;
	Izvori:Amigo / QuickGO
Ortolozi
	9894
	71718
	ENSG00000100726
	ENSMUSG00000024170
	Q9Y4R8
	Q9DC40
	NM_016111; NM_001351846
	NM_001163661; NM_027880
	NP_057195; NP_001338775
	NP_001157133; NP_082156
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

TEL2 homolog regulacijskog proteina telomerne dužine je protein koji je kod ljudi kodiran genom TELO2.^[5]^[6]^[7]^[8]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 837 aminokiselina, a molekulska težina 91.747 Da.^[9].

10	20	30	40	50
MEPAPSEVRL	AVREAIHALS	SSEDGGHIFC	TLESLKRYLG	EMEPPALPRE
KEEFASAHFS	PVLRCLASRL	SPAWLELLPH	GRLEELWASF	FLEGPADQAF
LVLMETIEGA	AGPSFRLMKM	ARLLARFLRE	GRLAVLMEAQ	CRQQTQPGFI
LLRETLLGKV	VALPDHLGNR	LQQENLAEFF	PQNYFRLLGE	EVVRVLQAVV
DSLQGGLDSS	VSFVSQVLGK	ACVHGRQQEI	LGVLVPRLAA	LTQGSYLHQR
VCWRLVEQVP	DRAMEAVLTG	LVEAALGPEV	LSRLLGNLVV	KNKKAQFVMT
QKLLFLQSRL	TTPMLQSLLG	HLAMDSQRRP	LLLQVLKELL	ETWGSSSAIR
HTPLPQQRHV	SKAVLICLAQ	LGEPELRDSR	DELLASMMAG	VKCRLDSSLP
PVRRLGMIVA	EVVSARIHPE	GPPLKFQYEE	DELSLELLAL	ASPQPAGDGA
SEAGTSLVPA	TAEPPAETPA	EIVDGGVPQA	QLAGSDSDLD	SDDEFVPYDM
SGDRELKSSK	APAYVRDCVE	ALTTSEDIER	WEAALRALEG	LVYRSPTATR
EVSVELAKVL	LHLEEKTCVV	GFAGLRQRAL	VAVTVTDPAP	VADYLTSQFY
ALNYSLRQRM	DILDVLTLAA	QELSRPGCLG	RTPQPGSPSP	NTPCLPEAAV
SQPGSAVASD	WRVVVEERIR	SKTQRLSKGG	PRQGPAGSPS	RFNSVAGHFF
FPLLQRFDRP	LVTFDLLGED	QLVLGRLAHT	LGALMCLAVN	TTVAVAMGKA
LLEFVWALRF	HIDAYVRQGL	LSAVSSVLLS	LPAARLLEDL	MDELLEARSW
LADVAEKDPD	EDCRTLALRA	LLLLQRLKNR	LLPPASP

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Funkcija

U 2007. istraživači su izvijestili o neočekivanoj ulozi Tel2 u ekspresiji svih proteinskih kinaza povezanih s sisarskim fosfatidilinozitol 3-kinazama (kinaza PIKK). Iako je Tel2 identificiran kao gen pupajućeg kvasca potreban za održavanje dužine telomera, nisu pronašli očiglednu telomernu funkciju sisarskog Tel2. Delecija Tel2 zaustavila je mTOR signalizaciju, ukazujući da Tel2 utiče na PIKK sisara. Tel2 se veže na dio HEAT-ponavljanja segmenata ATM-a i mTOR-a i visoko je konzervirani regulator stabilnosti PIKK-a.^[10]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100726 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024170 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
^ Jiang N, Benard CY, Kebir H, Shoubridge EA, Hekimi S (Jun 2003). "Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation". J Biol Chem. 278 (24): 21678–84. doi:10.1074/jbc.M300286200. PMID 12670948.
^ "Entrez Gene: TELO2 TEL2, telomere maintenance 2, homolog (S. cerevisiae)".
^ "UniProt, Q9Y4R8". Pristupljeno 9. 7. 2021.
^ Takai H, Wang R, Takai K, Yang H, De Lange T (2007). "Tel2 Regulates the Stability of PI3K-Related Protein Kinases". Cell. 131 (7): 1248–1259. doi:10.1016/j.cell.2007.10.052. PMID 18160036. S2CID 6297247.

Dopunska literatura

Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Vanjski linkovi

Q9Y4R8

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100726 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024170 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9734811-5] Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.

[pmid11230166-6] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[pmid12670948-7] Jiang N, Benard CY, Kebir H, Shoubridge EA, Hekimi S (Jun 2003). "Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation". J Biol Chem. 278 (24): 21678–84. doi:10.1074/jbc.M300286200. PMID 12670948.

[entrez-8] "Entrez Gene: TELO2 TEL2, telomere maintenance 2, homolog (S. cerevisiae)".

[UniProt-9] "UniProt, Q9Y4R8". Pristupljeno 9. 7. 2021.

[TakaiEtAl-10] Takai H, Wang R, Takai K, Yang H, De Lange T (2007). "Tel2 Regulates the Stability of PI3K-Related Protein Kinases". Cell. 131 (7): 1248–1259. doi:10.1016/j.cell.2007.10.052. PMID 18160036. S2CID 6297247.

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