TCEB3

TCEB3
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4HFX
Identifikatori
Aliasi	ELOA
Vanjski ID-jevi	OMIM: 600786 MGI: 1351315 HomoloGene: 37746 GeneCards: ELOA
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	23,762,059 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	135,749,074 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• jedro; • nukleoplazma; • Vanćelijsko; • elongin complex;
Biološki proces	• transcription elongation from RNA polymerase II promoter; • GO:0009373 regulation of transcription, DNA-templated; • transcription by RNA polymerase II; • transcription, DNA-templated; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	6924
	27224
	ENSG00000011007
	ENSMUSG00000028668
	Q14241
	Q8CB77
	NM_003198
	NM_013736
	NP_003189
	NP_038764
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Elongin A jest protein koji je kod ljudi kodiran genom ELOA sa hromosoma 1.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 798 aminokiselina, a molekulska težina 89.909 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MHGGRSCGPR	TRREPSSGEE	AAPVTAMAAE	SALQVVEKLQ	ARLAANPDPK
KLLKYLKKLS	TLPITVDILA	ETGVGKTVNS	LRKHEHVGSF	ARDLVAQWKK
LVPVERNAEP	DEQDFEKSNS	RKRPRDALQK	EEEMEGDYQE	TWKATGSRSY
SPDHRQKKHR	KLSELERPHK	VSHGHERRDE	RKRCHRMSPT	YSSDPESSDY
GHVQSPPSCT	SPHQMYVDHY	RSLEEDQEPI	VSHQKPGKGH	SNAFQDRLGA
SQERHLGEPH	GKGVVSQNKE	HKSSHKDKRP	VDAKSDEKAS	VVSREKSHKA
LSKEENRRPP	SGDNAREKPP	SSGVKKEKDR	EGSSLKKKCL	PPSEAASDNH
LKKPKHRDPE	KAKLDKSKQG	LDSFDTGKGA	GDLLPKVKEK	GSNNLKTPEG
KVKTNLDRKS	LGSLPKVEET	DMEDEFEQPT	MSFESYLSYD	QPRKKKKKIV
KTSATALGDK	GLKKNDSKST	GKNLDSVQKL	PKVNKTKSEK	PAGADLAKLR
KVPDVLPVLP	DLPLPAIQAN	YRPLPSLELI	SSFQPKRKAF	SSPQEEEEAG
FTGRRMNSKM	QVYSGSKCAY	LPKMMTLHQQ	CIRVLKNNID	SIFEVGGVPY
SVLEPVLERC	TPDQLYRIEE	YNHVLIEETD	QLWKVHCHRD	FKEERPEEYE
SWREMYLRLQ	DAREQRLRVL	TKNIQFAHAN	KPKGRQAKMA	FVNSVAKPPR
DVRRRQEKFG	TGGAAVPEKI	KIKPAPYPMG	SSHASASSIS	FNPSPEEPAY
DGPSTSSAHL	APVVSSTVSY	DPRKPTVKKI	APMMAKTIKA	FKNRFSRR

Funkcija

Elongin A je podjedinica kompleksa transkripcijskog faktora B (SIII). SIII kompleks se sastoji od elongina A/A2, B i C.

Aktivira elongaciju pomoću RNK-polimeraze II, suzbijanjem prolaznog zastoja polimeraze na mnogim mjestima unutar transkripcijskih jedinica. Elongin A funkcioniše kao transkripcijski aktivna komponenta SIII kompleksa, dok su elongini B i C regulatorne podjedinice. Elongin A2 je specifično eksprimiran u sjemenicima i sposoban je da formira stabilan kompleks sa elonginima B i C. Proteinski supresor von Hippel-Lindauovog tumora vezuje se za elongine B i C i na taj način inhibira elongaciju transkripcije.^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000011007 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028668 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Aso T, Mokady N, Haque D, Conaway RC, Conaway JW (Mar 1996). "Assignment of a human gene encoding the 110-kDa subunit of general transcription factor elongin (SIII) to chromosome 1p36.1". Genomics. 30 (2): 393–4. PMID 8586449.
^ Aso T, Lane WS, Conaway JW, Conaway RC (Oct 1995). "Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II". Science. 269 (5229): 1439–43. Bibcode:1995Sci...269.1439A. doi:10.1126/science.7660129. PMID 7660129. S2CID 37649908.
^ ^a ^b "ELOA elongin A [ Homo sapiens (human) ]".
^ "UniProt, Q14241" (jezik: en.). Pristupljeno 5. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

Shilatifard A (1998). "Factors regulating the transcriptional elongation activity of RNA polymerase II". FASEB J. 12 (14): 1437–46. doi:10.1096/fasebj.12.14.1437. PMID 9806752. S2CID 17435359.
Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
Aso T, Haque D, Fukudome K, et al. (1996). "A human cDNA encoding the 110-kDa A subunit of RNA polymerase II transcription factor elongin". Gene. 168 (2): 277–8. doi:10.1016/0378-1119(95)00750-4. PMID 8654961.
Pan G, Aso T, Greenblatt J (1997). "Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators". J. Biol. Chem. 272 (39): 24563–71. doi:10.1074/jbc.272.39.24563. PMID 9305922.
Ohh M, Takagi Y, Aso T, et al. (2000). "Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein". J. Clin. Invest. 104 (11): 1583–91. doi:10.1172/JCI8161. PMC 481054. PMID 10587522.
Kamura T, Burian D, Yan Q, et al. (2001). "Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase". J. Biol. Chem. 276 (32): 29748–53. doi:10.1074/jbc.M103093200. PMID 11384984.
Shaheduzzaman S, Krishnan V, Petrovic A, et al. (2002). "Effects of HIV-1 Nef on cellular gene expression profiles". J. Biomed. Sci. 9 (1): 82–96. doi:10.1007/BF02256581. PMID 11810028.
Yamazaki K, Guo L, Sugahara K, et al. (2002). "Identification and biochemical characterization of a novel transcription elongation factor, Elongin A3". J. Biol. Chem. 277 (29): 26444–51. doi:10.1074/jbc.M202859200. PMID 11994304.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tamura K, Miyata K, Sugahara K, et al. (2003). "Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain". Biochem. Biophys. Res. Commun. 309 (1): 189–95. doi:10.1016/S0006-291X(03)01556-0. PMID 12943681.
Stoletov KV, Terman BI (2004). "Bmx is a downstream Rap1 effector in VEGF-induced endothelial cell activation". Biochem. Biophys. Res. Commun. 320 (1): 70–5. doi:10.1016/j.bbrc.2004.05.134. PMID 15207703.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Woo JS, Imm JH, Min CK, et al. (2006). "Structural and functional insights into the B30.2/SPRY domain". EMBO J. 25 (6): 1353–63. doi:10.1038/sj.emboj.7600994. PMC 1422157. PMID 16498413.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000011007 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028668 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8586449-5] Aso T, Mokady N, Haque D, Conaway RC, Conaway JW (Mar 1996). "Assignment of a human gene encoding the 110-kDa subunit of general transcription factor elongin (SIII) to chromosome 1p36.1". Genomics. 30 (2): 393–4. PMID 8586449.

[pmid7660129-6] Aso T, Lane WS, Conaway JW, Conaway RC (Oct 1995). "Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II". Science. 269 (5229): 1439–43. Bibcode:1995Sci...269.1439A. doi:10.1126/science.7660129. PMID 7660129. S2CID 37649908.

[entrez-7] "ELOA elongin A [ Homo sapiens (human) ]".

[UniProt-8] "UniProt, Q14241" (jezik: en.). Pristupljeno 5. 12. 2021.CS1 održavanje: nepoznati jezik (link)

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