Wikipedia

TBC1D12

Član 12 domenske porodice TBC1 jest protein koji je kod ljudi kodiran genom TBC1D12.[5]

TBC1D12
Identifikatori
AliasiTBC1D12
Vanjski ID-jeviMGI: 2384803 HomoloGene: 50835 GeneCards: TBC1D12
Lokacija gena (čovjek)
Hromosom 10 (čovjek)
Hrom.Hromosom 10 (čovjek)[1]
Hromosom 10 (čovjek)
Genomska lokacija za TBC1D12
Genomska lokacija za TBC1D12
Bend10q23.33Početak94,402,541 bp[1]
Kraj94,536,332 bp[1]
Lokacija gena (miš)
Hromosom 19 (miš)
Hrom.Hromosom 19 (miš)[2]
Hromosom 19 (miš)
Genomska lokacija za TBC1D12
Genomska lokacija za TBC1D12
Bend19|19 C3Početak38,825,023 bp[2]
Kraj38,908,367 bp[2]
Ontologija gena
Molekularna funkcija• GO:0005097, GO:0005099, GO:0005100 GTPase activator activity
Ćelijska komponenta• Autofagosom
• reciklirajući endosom
• intracellular anatomical structure
Biološki proces• regulation of vesicle fusion
• regulation of autophagosome assembly
• intracellular protein transport
• GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

23232

209478

Ensembl

ENSG00000108239

ENSMUSG00000048720

UniProt

O60347

Q6A039

RefSeq (mRNK)

NM_015188

NM_145952
NM_001362424

RefSeq (bjelančevina)

NP_056003

NP_666064
NP_001349353

Lokacija (UCSC)Chr 10: 94.4 – 94.54 MbChr 19: 38.83 – 38.91 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

uredi

Dužina polipeptidnog lanca je 775 aminokiselina, а molekulska težina 85.626 Da.[6]

1020304050
MVGPEDAGACSGRNPKLLPVPAPDPVGQDRKVIRATGGFGGGVGAVEPPE
EADEEEEADEEEETPPRQLLQRYLAAAGEQLEPGLCYCPLPAGQAGAPPP
SAAPRSDACLLGSGSKHRGAEVADGRAPRHEGMTNGDSGFLPGRDCRDLE
EARGLARAGGRESRRRRPYGRLRLEGPGDEDADGAGSPSDWASPLEDPLR
SCCLVAADAQEPEGAGSDSGDSPASSCSSSEDSEQRGVGAGGPEEGAPPA
TSAERTNGGAEPRLGFSDIHFNSRNTFQVSRGQSARDHLPPAGPPVPLPA
AEQGPAGASARARRSGGFADFFTRNLFPKRTKELKSVVHSAPGWKLFGKV
PPRENLQKTSKIIQQEYEARTGRTCKPPPQSSRRKNFEFEPLSTTALILE
DRPSNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQE
ENIASAMVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGN
ELNITPELYEIFLSRAKERWKSFSETSSENDTEGVSVADREASLELIKLD
ISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLIL
NLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLF
LHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTG
LGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKK
WTQVFASVMKDIKEGDKNSSPALKS
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108239 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048720 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: TBC1 domain family, member 12".
  6. ^ "UniProt, O60347". Pristupljeno 5. 9. 2021.

Dopunska literatura

uredi
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