STEAP1

STEAP1
Identifikatori
Aliasi	STEAP1
Vanjski ID-jevi	OMIM: 604415 MGI: 1917608 HomoloGene: 8256 GeneCards: STEAP1
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	90,164,829 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	5,799,326 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• ferric-chelate reductase (NADPH) activity; • vezivanje iona metala; • transporter activity; • oxidoreductase activity; • cupric reductase activity; • channel activity;
Ćelijska komponenta	• endosome membrane; • integral component of membrane; • cell-cell junction; • integral component of plasma membrane; • membrana; • endozom; • ćelijska membrana;
Biološki proces	• ion transport; • copper ion import; • iron ion homeostasis; • transmembrane transport; • iron ion import across cell outer membrane;
	Izvori:Amigo / QuickGO
Ortolozi
	26872
	70358
	ENSG00000164647
	ENSMUSG00000015652
	Q9UHE8
	Q9CWR7
	NM_012449
	NM_027399
	NP_036581
	NP_081675
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Metaloreduktaza STEAP1 jest enzim koji je kod ljudi kodiran genom STEAP1.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 399 aminokiselina, а molekulska težina 39.851 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MESRKDITNQ	EELWKMKPRR	NLEEDDYLHK	DTGETSMLKR	PVLLHLHQTA
HADEFDCPSE	LQHTQELFPQ	WHLPIKIAAI	IASLTFLYTL	LREVIHPLAT
SHQQYFYKIP	ILVINKVLPM	VSITLLALVY	LPGVIAAIVQ	LHNGTKYKKF
PHWLDKWMLT	RKQFGLLSFF	FAVLHAIYSL	SYPMRRSYRY	KLLNWAYQQV
QQNKEDAWIE	HDVWRMEIYV	SLGIVGLAIL	ALLAVTSIPS	VSDSLTWREF
HYIQSKLGIV	SLLLGTIHAL	IFAWNKWIDI	KQFVWYTPPT	FMIAVFLPIV
VLIFKSILFL	PCLRKKILKI	RHGWEDVTKI	NKTEICSQL

Funkcija

Ovaj gen se pretežno eksprimira u prostatnom tkivu, a utvrđeno je da je reguliran u više ćelijskih linija raka. Predviđeno je da je genski proizvod ima šestotransmembranski protein, a pokazalo se da je to antigen ćelijske površine, značajno eksprimiran na vezama ćelija-ćelija.^[5]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164647 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015652 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: STEAP1 six transmembrane epithelial antigen of the prostate 1".
^ "UniProt, Q9UHE8" (jezik: engleski). Pristupljeno 29. 9. 2021.

Dopunska literatura

Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Hubert RS, Vivanco I, Chen E, et al. (2000). "STEAP: A prostate-specific cell-surface antigen highly expressed in human prostate tumors". Proc. Natl. Acad. Sci. U.S.A. 96 (25): 14523–8. doi:10.1073/pnas.96.25.14523. PMC 24469. PMID 10588738.
Yang D, Holt GE, Velders MP, et al. (2001). "Murine six-transmembrane epithelial antigen of the prostate, prostate stem cell antigen, and prostate-specific membrane antigen: prostate-specific cell-surface antigens highly expressed in prostate cancer of transgenic adenocarcinoma mouse prostate mice". Cancer Res. 61 (15): 5857–60. PMID 11479226.
Korkmaz KS, Elbi C, Korkmaz CG, et al. (2002). "Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer". J. Biol. Chem. 277 (39): 36689–96. doi:10.1074/jbc.M202414200. PMID 12095985.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rodeberg DA, Nuss RA, Elsawa SF, Celis E (2005). "Recognition of Six-Transmembrane Epithelial Antigen of the Prostate–Expressing Tumor Cells by Peptide Antigen–Induced Cytotoxic T Lymphocytes". Clin. Cancer Res. 11 (12): 4545–52. doi:10.1158/1078-0432.CCR-04-2235. PMC 1698136. PMID 15958640.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164647 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015652 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: STEAP1 six transmembrane epithelial antigen of the prostate 1".

[UniProt-6] "UniProt, Q9UHE8" (jezik: engleski). Pristupljeno 29. 9. 2021.

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